公开(公告)号：US20100173283A1

公开(公告)日：2010-07-08

申请号：US12642553

申请日：2009-12-18

申请人： Kazuaki Takahashi ,  Natsumi Abe ,  Sheikh Mohammad Fazle Akbar ,  Michie Hashimoto

发明人： Kazuaki Takahashi ,  Natsumi Abe ,  Sheikh Mohammad Fazle Akbar ,  Michie Hashimoto

IPC分类号： C12Q1/70

CPC分类号： C12Q1/707 ,  C07K14/005 ,  C12N7/00 ,  C12N2770/28121 ,  C12N2770/28122

摘要： The present invention provides a method of predicting potential severity of hepatitis, includes determining that hepatitis in a subject is potentially severe when it is detected that any amino acid is mutated to an amino acid of genotype-4, the any amino acid being amino acid of an amino acid sequence in a region encoded by ORF1 of an HEV genome RNA of genotype 3, and the HEV genome RNA being contained in a specimen nucleic acid taken from the subject infected with genotype-3 HEV.

摘要翻译： 本发明提供一种预测肝炎潜在严重程度的方法，包括确定当检测到任何氨基酸被突变为基因型-4的氨基酸时，受试者中的肝炎可能是严重的，任何氨基酸是氨基酸的氨基酸 由基因型3的HEV基因组RNA由ORF1编码的区域中的氨基酸序列，以及从感染基因型3 HEV的受试者取得的标本核酸中包含的HEV基因组RNA。