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公开(公告)号:US20120010139A1
公开(公告)日:2012-01-12
申请号:US13172776
申请日:2011-06-29
申请人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
发明人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
CPC分类号: A61L27/50 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A (Formula I) and B-A-B-(BOX-B-A-B)n-BOX-B-A-B Formula (II), wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
摘要翻译: 提供了用于治疗骨疾病的热应答组合物。 用于治疗骨疾病的热应答组合物包括骨生长因子和可生物降解的共聚物。 生物降解性共聚物具有式(I)或式(II)的结构:AB-BOX-BA(式I)和BAB-(BOX-BAB)n-BOX-BAB式(II),其中,A包括亲水 聚乙二醇聚合物,B包括疏水性聚酯聚合物,BOX是2,2'-双(2-恶唑啉)的双官能团单体,用于偶联嵌段AB或BAB,并且n为整数并且相同或多于 0。
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公开(公告)号:US08614190B2
公开(公告)日:2013-12-24
申请号:US13172776
申请日:2011-06-29
申请人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
发明人: Shen-Hua Peng , Hsin-Hsin Shen , Liang-Yo Yang , Meng-Yow Hsieh , Pei-Shan Li , Wei-Lin Yu , Tsai-Yu Lin , Po-Liang Lai , Jui-Sheng Sun , Chih-Hung Chang , Yi-Hung Lin
IPC分类号: A61P19/08 , A61K38/18 , A61K31/74 , C07K14/51 , C07K14/475
CPC分类号: A61L27/50 , A61L27/18 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要: Thermal responsive compositions for treating bone diseases are provided. The thermal responsive composition for treating bone diseases includes a bone growth factor and a biodegradable copolymer. The biodegradable copolymer has a structure of Formula (I) or Formula (II): A-B-BOX-B-A Formula (I) B-A-B-(BOX-B-A-B)n-BOX-B-A-B Formula (II) wherein, A includes a hydrophilic polyethylene glycol polymer, B includes a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2, 2′-Bis(2-oxazoline) and used for coupling the blocks A-B or B-A-B, and n is an integer and the same or more than 0.
摘要翻译: 提供了用于治疗骨疾病的热应答组合物。 用于治疗骨疾病的热应答组合物包括骨生长因子和可生物降解的共聚物。 生物降解性共聚物具有式(I)或式(II)的结构:AB-BOX-B-AFormula(I)BAB-(BOX-BAB)n-BOX-BA-BFormula(II)其中,A包括亲水 聚乙二醇聚合物,B包括疏水性聚酯聚合物,BOX是2,2'-双(2-恶唑啉)的双官能团单体,用于偶联嵌段AB或BAB,并且n是整数并且相同或多于 0。
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