公开(公告)号：US20140128463A1

公开(公告)日：2014-05-08

申请号：US14129000

申请日：2012-06-25

申请人： Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

发明人： Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

IPC分类号： C07C235/84 ,  C07C231/02

CPC分类号： C07C235/84 ,  A61K31/165 ,  A61K31/166 ,  A61K31/222 ,  C07C231/02 ,  C07C235/20 ,  C07C235/26 ,  C07C251/24 ,  C07C325/02 ,  C07C2601/02 ,  C07C2601/14

摘要： Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.

摘要翻译： 公开了酰胺化合物，其制备方法和用途，具体地，由式I表示的化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，Q，X和n如描述中所定义。 还公开了制备式I化合物的方法，含有该化合物的组合物及其在制备用于调节血脂和/或预防胆结石的药物中的用途。 本发明公开的式I化合物在体外具有稳定性，在药用有机溶剂中的溶解性好，动物中具有良好的生物利用度。

公开(公告)号：US10428013B2

公开(公告)日：2019-10-01

申请号：US14129000

申请日：2012-06-25

申请人： Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

发明人： Zhenpeng Yu ,  Gouping Wang ,  Zhen Zhang ,  Minyu Liu ,  Xiaoling Huang ,  Ying Liu ,  Lin Xiao ,  Li Cai ,  Xuejun Wu ,  Yifang Deng ,  Mianli Pan ,  Renhai Chen ,  Shenrong Tang ,  Quanhai Liu

IPC分类号： C07C235/84 ,  A61K31/165 ,  A61K31/166 ,  A61K31/222 ,  C07C325/02 ,  C07C235/20 ,  C07C235/26 ,  C07C251/24 ,  C07C231/02

摘要： Disclosed are amide compounds, preparation method and uses thereof, specifically, the compounds represented by formula I or pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, Q, X and n are defined as in the description. Also disclosed are a method for preparing the compounds of formula I, a composition containing the compounds, and the uses of the same in the preparation of medicaments for regulating blood lipid and/or preventing gallstone. The compounds of formula I disclosed in the present invention have stability in vitro, good solubility in the pharmaceutical organic solvents and favorable bioavailability in animals.