公开(公告)号：US20090143430A1

公开(公告)日：2009-06-04

申请号：US12326204

申请日：2008-12-02

申请人： Shigehiko IMAGAWA ,  Takeshi Doi ,  Masahiro Tamura ,  Masao Ohkuchi

发明人： Shigehiko IMAGAWA ,  Takeshi Doi ,  Masahiro Tamura ,  Masao Ohkuchi

IPC分类号： A61K31/4545

CPC分类号： A61K31/444 ,  A61K31/4468 ,  A61K31/4545 ,  C07D211/58 ,  C07D213/38 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to a preventive or therapeutic agent for pathological conditions caused by reduced production of erythropoietin, or for anemia, or for chronic anemia, renal anemia, aplastic anemia, or pure red cell aplasia, the agent comprising, as an active ingredient, a cyclic amine compound represented by the following formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group; W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group; and l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.

摘要翻译： 本发明涉及由促红细胞生成素或贫血，贫血，慢性贫血，肾性贫血，再生障碍性贫血或纯红细胞发育不全引起的病理状况的预防或治疗剂，所述药物包含作为活性成分的， 由下式（1）表示的环胺化合物：其中，R 1，R 2和R 3各自独立地表示氢原子，卤素原子或羟基，烷基，卤素取代的烷基，烷氧基，烷硫基，羧基，烷氧基羰基或烷酰基 组; W1和W2各自独立地表示N或CH; X表示O，NR4，CONR4或NR4CO; R 4各自表示氢原子，或烷基，烯基，炔基，取代或未取代的芳基，取代或未取代的杂芳基，取代或未取代的芳烷基或取代或未取代的杂芳烷基; l，m和n各自表示0或1的数，或其盐或其溶剂合物。

公开(公告)号：US20050282751A1

公开(公告)日：2005-12-22

申请号：US11082917

申请日：2005-03-18

申请人： Takahisa Tarumoto ,  Shigehiko Imagawa

发明人： Takahisa Tarumoto ,  Shigehiko Imagawa

IPC分类号： A61K31/198 ,  A61K33/26 ,  A61K38/18

CPC分类号： A61K33/26 ,  A61K31/198 ,  A61K38/1816 ,  A61K2300/00

摘要： There is provided an agent for preventing or treating renal anemia, which contains arginine as an active ingredient. This agent for preventing or treating renal anemia can be easily administered and the administration can be controlled at home to obtain excellent effect in preventing or treating renal anemia.

摘要翻译： 提供了用于预防或治疗含有精氨酸作为活性成分的肾性贫血的药剂。 可以容易地施用这种预防或治疗肾性贫血的药剂，并且可以在家中控制给药以获得预防或治疗肾性贫血的优异效果。

公开(公告)号：US20060040986A1

公开(公告)日：2006-02-23

申请号：US10537407

申请日：2003-12-05

申请人： Shigehiko Imagawa ,  Takeshi Dol ,  Masahiro Tamura ,  Masao Ohkuchi

发明人： Shigehiko Imagawa ,  Takeshi Dol ,  Masahiro Tamura ,  Masao Ohkuchi

IPC分类号： A61K31/4545 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/40 ,  C07D403/02 ,  C07D401/14

CPC分类号： A61K31/444 ,  A61K31/4468 ,  A61K31/4545 ,  C07D211/58 ,  C07D213/38 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to a preventive or therapeutic agent for pathological conditions caused by reduced production of erythropoietin, or for anemia, or for chronic anemia, renal anemia, aplastic anemia, or pure red cell aplasia, the agent comprising, as an active ingredient, a cyclic amine compound represented by the following formula (1): wherein, R1, R2 and R3 each independently represent a hydrogen atom, a halogen atom, or hydroxy, alkyl, halogen-substituted alkyl, alkoxy, alkylthio, carboxyl, alkoxycarbonyl or alkanoyl group; W1 and W2 each independently represent N or CH; X represents O, NR4, CONR4 or NR4CO; R4 each represents a hydrogen atom, or an alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, or substituted or unsubstituted heteroaralkyl group; and l, m and n each represents a number of 0 or 1, or a salt thereof or a solvate thereof.

摘要翻译： 本发明涉及由促红细胞生成素或贫血，贫血，慢性贫血，肾性贫血，再生障碍性贫血或纯红细胞发育不全引起的病理状况的预防或治疗剂，所述药物包含作为活性成分的， 由下式（1）表示的环胺化合物：其中R 1，R 2和R 3各自独立地表示氢原子 卤素原子或羟基，烷基，卤素取代的烷基，烷氧基，烷硫基，羧基，烷氧基羰基或烷酰基; W 1和W 2各自独立地表示N或CH; X表示O，NR 4，CONR 4或NR 4 CO; R 4各自表示氢原子或烷基，烯基，炔基，取代或未取代的芳基，取代或未取代的杂芳基，取代或未取代的芳烷基或取代或未取代的杂芳烷基; l，m和n各自表示0或1的数，或其盐或其溶剂合物。