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    Crown ether amines and methods of use
    1.
    发明授权
    Crown ether amines and methods of use 有权

    公开(公告)号：US12122758B2

    公开(公告)日：2024-10-22

    申请号：US18242305

    申请日：2023-09-05

    申请人： Pall Corporation

    发明人： Andrew Kocen ,  Rehanah Sejoubsari ,  Ahmad Arabi Shams Abadi

    IPC分类号： C07D323/00 ,  B01D53/22 ,  B01D71/06

    CPC分类号： C07D323/00 ,  B01D53/228 ,  B01D71/06

    摘要： The invention provides a material comprising (i) a crown ether of formula (I) and/or (ii) a crown ether of formula (II), or a salt thereof, wherein each m independently is an integer from 1 to 8, each “” designates an optionally present bond and/or structure, each X independently is —N(R1)2, —N*(R1), —N**, —N*(R1)2+Z−, or —N**(R1)+Z−, provided at least one X is —N*(R1), —N**, —N*(R1)2+Z−, or —N**(R1)+Z−, wherein each R1 independently is hydrogen or C1-6 alkyl, each Z is optionally present and independently is a counterion to balance the charge on nitrogen, and * represents a bond to a remainder of the material, a method of making the material, and a method of using the material.

    THERAPEUTIC COMPOSITIONS
    2.
    发明申请
    THERAPEUTIC COMPOSITIONS 审中-公开

    公开(公告)号：US20180098956A1

    公开(公告)日：2018-04-12

    申请号：US15787116

    申请日：2017-10-18

    申请人： BTG INTERNATIONAL LIMITED

    发明人： Richard L. Veech

    IPC分类号： A61K31/22 ,  C07D323/00 ,  C07C69/72 ,  A23L33/105 ,  A61K31/365 ,  C07C67/46 ,  C07C67/14 ,  A61K31/19

    CPC分类号： A61K31/22 ,  A23L33/105 ,  A61K31/19 ,  A61K31/365 ,  C07B2200/07 ,  C07C67/14 ,  C07C67/46 ,  C07C69/72 ,  C07D323/00

    摘要： Compositions comprising ketone bodies and/or their metabolic precursors are provided that are suitable for administration to humans and animals and which have the properties of, inter alia, (i) increasing cardiac efficiency, particularly efficiency in use of glucose, (ii) for providing energy source, particularly in diabetes and insulin resistant states and (iii) treating disorders caused by damage to brain cells, particularly by retarding or preventing brain damage in memory associated brain areas such, as found in Alzheimer's and similar conditions.These compositions may be taken as nutritional aids, for example for athletes, or for the treatment of medical conditions, particularly those associated with poor cardiac efficiency, insulin resistance and neuronal damage. The invention further provides methods of treatment and novel esters and polymers for inclusion in the compositions of the invention.

    BENZOCROWN ETHER GRAFT POLYMER WITH LITHIUM ISOTOPIC SEPARATION EFFECT AND PREPARATION METHOD THEREOF
    7.
    发明申请
    BENZOCROWN ETHER GRAFT POLYMER WITH LITHIUM ISOTOPIC SEPARATION EFFECT AND PREPARATION METHOD THEREOF 有权
    具有同位素同位素分离效应的苯并二氮丙烯聚合物及其制备方法

    公开(公告)号：US20150152201A1

    公开(公告)日：2015-06-04

    申请号：US14612012

    申请日：2015-02-02

    申请人： TIANJIN POLYTECHNIC UNIVERSITY

    发明人： JIANXIN LI ,  FENG YAN ,  BENQIAO HE ,  HONG WANG

    IPC分类号： C08F8/00 ,  C08G65/48 ,  C08G75/23 ,  C08G75/20

    CPC分类号： C08F8/00 ,  B01D59/22 ,  B01J20/265 ,  C07D323/00 ,  C08G65/48 ,  C08G75/20 ,  C08G75/23 ,  C08G83/00 ,  C08G2650/40 ,  C08L101/005 ,  C08F216/06 ,  C08F220/06

    摘要： Disclosed in the present invention is a benzocrown ether graft polymer with a lithium isotopic separation effect and a preparation method thereof. The polymer is a benzocrown ether graft polymer formed by the linkage of chemical bonds, which takes the main chain of a polymer containing chloromethyl group, chloroformyl group or hydroxyl group as main chain, and takes a benzocrown ether as pendant group. The preparation process of the polymer comprises the following steps: preparing polymer solution with certain concentration by dissolving a polymer containing chloromethyl group, chloroformyl group or hydroxyl group in a solvent; then blending a catalyst and a benzocrown ether containing carboxyl group or aldehydyl group and dissolving in the polymer solution containing hydroxyl group, or blending an acid-binding agent and a benzocrown ether containing amino group or hydroxyl group and dissolving in the polymer solution containing chloromethyl group or chloroformyl group, reacting at a certain temperature and for a certain time, linking the benzocrown ether to the main chain of polymer by chemical bonds, and precipitating by adding a precipitating agent to obtain the graft polymer. The grafting polymer has excellent characteristic of lithium isotopic separation.

    摘要翻译： 在本发明中公开了具有锂同位素分离效果的苯并长链接枝聚合物及其制备方法。 聚合物是通过化学键连接形成的苯并长链醚接枝聚合物，其以氯甲基，氯甲酰基或羟基为主链的聚合物的主链为主链，并以苯并四氢呋喃作为侧基。 聚合物的制备方法包括以下步骤：通过将含有氯甲基，氯甲酰基或羟基的聚合物溶解在溶剂中来制备一定浓度的聚合物溶液; 然后混合催化剂和含有羧基或醛基的苯并长链醚，并溶解在含有羟基的聚合物溶液中，或掺入酸结合剂和含有氨基或羟基的苯并环己基醚，并溶解在含氯甲基的聚合物溶液中 或氯甲酰基，在一定温度下反应一定时间，通过化学键将苯扎洛醚与聚合物主链连接，并通过加入沉淀剂沉淀得到接枝聚合物。 接枝聚合物具有优异的锂同位素分离特性。

    PRODUCTION OF CYCLIC ACETALS OR KETALS USING SOLID ACID CATALYSTS
    9.
    发明申请
    PRODUCTION OF CYCLIC ACETALS OR KETALS USING SOLID ACID CATALYSTS 审中-公开
    使用固体酸催化剂生产循环乙醇或咖啡

    公开(公告)号：US20140330029A1

    公开(公告)日：2014-11-06

    申请号：US14337544

    申请日：2014-07-22

    申请人： Eastman Chemical Company

    发明人： Daniel Latham Terrill ,  Brian David McMurray ,  Damon Ray Billodeaux ,  James Lon Little ,  Adam Scott Howard

    IPC分类号： C07D323/00 ,  C07D319/12 ,  C07D321/08 ,  C07D317/12

    CPC分类号： C07D323/00 ,  C07D317/12 ,  C07D319/12 ,  C07D321/06 ,  C07D321/08

    摘要： A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.

    摘要翻译： 通过将醛或酮化合物和多羟基化合物以多羟基化合物与醛或酮化合物的摩尔比至少为3:1的比例将醛或酮化合物和多羟基化合物进料到反应区中来制备环状化合物如环缩醛或环酮的方法，使这些化合物在 固体酸如酸性离子交换树脂的存在，以便在反应混合物中形成液体反应混合物而不从反应混合物中分离出水，以液体产物的形式从反应区抽出液体反应混合物 流，并将液体反应产物流进料到蒸馏塔中以从未反应的多羟基化合物中分离出环状缩醛化合物，并任选地将未反应的多羟基化合物回收到反应区。 该方法产生环状缩醛化合物，产率至少为90％，催化剂寿命长。 该方法也适用于由酮化合物制备环状缩酮。

    Production of cyclic acetals or ketals using solid acid catalysts
    10.
    发明授权
    Production of cyclic acetals or ketals using solid acid catalysts 有权
    使用固体酸催化剂制备环状缩醛或缩酮

    公开(公告)号：US08829206B2

    公开(公告)日：2014-09-09

    申请号：US13168330

    申请日：2011-06-24

    申请人： Daniel Latham Terrill ,  Brian David McMurray ,  Damon Ray Billodeaux ,  James Lon Little ,  Adam Scott Howard

    发明人： Daniel Latham Terrill ,  Brian David McMurray ,  Damon Ray Billodeaux ,  James Lon Little ,  Adam Scott Howard

    IPC分类号： C07D321/00 ,  C07D317/12 ,  C07D321/06 ,  C07D319/12

    CPC分类号： C07D323/00 ,  C07D317/12 ,  C07D319/12 ,  C07D321/06 ,  C07D321/08

    摘要： A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.

    摘要翻译： 通过将醛或酮化合物和多羟基化合物以多羟基化合物与醛或酮化合物的摩尔比至少为3:1的比例将醛或酮化合物和多羟基化合物进料到反应区中来制备环状化合物如环缩醛或环酮的方法，使这些化合物在 固体酸如酸性离子交换树脂的存在，以便在反应混合物中形成液体反应混合物而不从反应混合物中分离出水，以液体产物的形式从反应区抽出液体反应混合物 流，并将液体反应产物流进料到蒸馏塔中以从未反应的多羟基化合物中分离出环状缩醛化合物，并任选地将未反应的多羟基化合物回收到反应区。 该方法产生环状缩醛化合物，产率至少为90％，催化剂寿命长。 该方法也适用于由酮化合物制备环状缩酮。