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1.发明申请公开(公告)号：US20120244542A1
公开(公告)日：2012-09-27
申请号：US13438464
申请日：2012-04-03
Applicant: Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
Inventor： Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
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Patent Agency Ranking
2.发明申请Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases 有权人IL-23受体（IL-23R）mRNA的剪接变体和δ9同种型在预测炎症性肠病中的应用公开(公告)号：US20090311694A1
公开(公告)日：2009-12-17
申请号：US12386146
申请日：2009-04-14
Applicant: Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
Inventor： Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
CPC classification number: C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
Abstract translation: 公开了由人IL-23R mRNA的选择性剪接引起的人IL-23R剪接变体的克隆和鉴定。 通过在IL-23R基因内跳过一个，多个完整外显子或部分外显子，发生替代的mRNA形式。 共鉴定了25种不同的IL-23R转录物。 公开了白细胞介素23受体中的新型外显子缺失（外显子9）同种型，表示为Delta9。 本申请还描述了用于测量不同IL-23R同种型的定量测定。 检测IL-23R的Delta9同种型主要存在于结肠和子宫颈组织中。 在Crohn患者的发炎结肠组织中观察到Delta9的减少。 公开了通过测量IL-23R的Delta9同种型来预测克罗恩病的方法。
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3.发明申请SPLICE VARIANTS OF HUMAN IL-23 RECEPTOR (IL-23R) mRNA AND USE OF A DELTA 9 ISOFORM IN PREDICTING INFLAMMATORY BOWEL DISEASES 审中-公开人类IL-23受体（IL-23R）mRNA的差异变异和DELTA 9感染在预防炎症性皮肤病中的应用公开(公告)号：US20130196333A1
公开(公告)日：2013-08-01
申请号：US13764827
申请日：2013-02-12
Applicant: Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
Inventor： Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
IPC: C12Q1/68
CPC classification number: C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
Abstract translation: 公开了由人IL-23R mRNA的选择性剪接引起的人IL-23R剪接变体的克隆和鉴定。 通过在IL-23R基因内跳过一个，多个完整外显子或部分外显子，发生替代的mRNA形式。 共鉴定了25种不同的IL-23R转录物。 公开了白细胞介素23受体中的新型外显子缺失（外显子9）同种型，表示为Delta9。 本申请还描述了用于测量不同IL-23R同种型的定量测定。 检测IL-23R的Delta9同种型主要存在于结肠和子宫颈组织中。 在Crohn患者的发炎结肠组织中观察到Delta9的减少。 公开了通过测量IL-23R的Delta9同种型来预测克罗恩病的方法。
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4.发明授权Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a Δ9 isoform in predicting inflammatory bowel diseases 有权人IL-23受体（IL-23R）mRNA的剪接变体以及在预测炎症性肠病中使用＆Dgr。9同种型公开(公告)号：US08404824B2
公开(公告)日：2013-03-26
申请号：US13438456
申请日：2012-04-03
Applicant: Gant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
Inventor： Gant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
CPC classification number: C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
Abstract translation: 公开了由人IL-23R mRNA的选择性剪接引起的人IL-23R剪接变体的克隆和鉴定。 通过在IL-23R基因内跳过一个，多个完整外显子或部分外显子，发生替代的mRNA形式。 共鉴定了25种不同的IL-23R转录物。 公开了白细胞介素23受体中的新型外显子缺失（外显子9）同种型，表示为＆Dgr; 9。 本申请还描述了用于测量不同IL-23R同种型的定量测定。 检测IL-23R的＆Dgr。9同种型主要存在于结肠和子宫颈组织中。 在克罗恩病患者的发炎结肠组织中观察到“Dgr”降低9。 公开了通过测量IL-23R的Dgr 9同种型来预测克罗恩病的方法。
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5.发明申请SPLICE VARIANTS OF HUMAN IL-23 RECEPTOR (IL-23R) mRNA AND USE OF A DELTA9 ISOFORM IN PREDICTING INFLAMMATORY BOWEL DISEASES 有权人类IL-23受体（IL-23R）mRNA的差异变体和DELTA9 ISOFORM在预防炎症性皮肤病中的应用公开(公告)号：US20120245325A1
公开(公告)日：2012-09-27
申请号：US13438456
申请日：2012-04-03
Applicant: Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
Inventor： Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
IPC: C07K14/54
CPC classification number: C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
Abstract translation: 公开了由人IL-23R mRNA的选择性剪接引起的人IL-23R剪接变体的克隆和鉴定。 通过在IL-23R基因内跳过一个，多个完整外显子或部分外显子，发生替代的mRNA形式。 共鉴定了25种不同的IL-23R转录物。 公开了白细胞介素23受体中的新型外显子缺失（外显子9）同种型，表示为＆Dgr; 9。 本申请还描述了用于测量不同IL-23R同种型的定量测定。 检测IL-23R的＆Dgr。9同种型主要存在于结肠和子宫颈组织中。 在克罗恩病患者的发炎结肠组织中观察到“Dgr”降低9。 公开了通过测量IL-23R的Dgr 9同种型来预测克罗恩病的方法。
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6.发明授权Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases 有权人IL-23受体（IL-23R）mRNA的剪接变体和δ9同种型在预测炎症性肠病中的应用公开(公告)号：US08206925B2
公开(公告)日：2012-06-26
申请号：US12386146
申请日：2009-04-14
Applicant: Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
Inventor： Grant Gallagher , Raymond Yu , Shih-hsin Kan , Giacomo Mancini
CPC classification number: C12Q1/6876 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.
Abstract translation: 公开了由人IL-23R mRNA的选择性剪接引起的人IL-23R剪接变体的克隆和鉴定。 通过在IL-23R基因内跳过一个，多个完整外显子或部分外显子，发生替代的mRNA形式。 共鉴定了25种不同的IL-23R转录物。 公开了白细胞介素23受体中的新型外显子缺失（外显子9）同种型，表示为＆Dgr; 9。 本申请还描述了用于测量不同IL-23R同种型的定量测定。 检测IL-23R的＆Dgr。9同种型主要存在于结肠和子宫颈组织中。 在克罗恩病患者的发炎结肠组织中观察到“Dgr”降低9。 公开了通过测量IL-23R的Dgr 9同种型来预测克罗恩病的方法。
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