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    Method and apparatus for performing force unit access writes on a disk
    2.
    发明授权
    Method and apparatus for performing force unit access writes on a disk 有权
    用于执行强制单元访问的方法和装置写入磁盘

    公开(公告)号：US08990493B1

    公开(公告)日：2015-03-24

    申请号：US13174547

    申请日：2011-06-30

    Applicant: Raymond Yu ,  Srinivas Neppalli ,  Brian E. Jones

    Inventor： Raymond Yu ,  Srinivas Neppalli ,  Brian E. Jones

    IPC: G06F12/00

    CPC classification number: G06F12/0866 ,  G06F3/06

    Abstract: A disk drive comprising a rotatable disk, a head actuated over the disk, and a controller is disclosed. The controller is configured to write a first force unit access write data to the cache as part of the cache data, write the first force unit access write data and a first metadata corresponding to the first force unit access write data to the first location by using the head, transmit a first write complete status to a host, and maintain the first force unit access write data in the cache as part of the cache data. The controller is also configured to store write data as part of the cache data. Furthermore, the controller is configured to write the cache data to a third location, and a metadata corresponding to the cache data to the disk.

    Abstract translation: 公开了一种包括可旋转盘，在盘上致动的头部和控制器的盘驱动器。 控制器被配置为将第一强制单元写入高速缓存中的写入数据作为高速缓存数据的一部分，将第一强制单元访问写入数据和对应于第一强制单元的第一元数据写入第一位置，通过使用 头部向主机发送第一个写入完成状态，并且将高速缓存数据的一部分保持在高速缓存中的第一强制单元访问写入数据。 控制器还被配置为将写入数据存储为高速缓存数据的一部分。 此外，控制器被配置为将高速缓存数据写入第三位置，并将对应于高速缓存数据的元数据写入盘。

    Anti-sense oligonucleotides targeted against exon 9 of IL-23Rα gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases
    3.
    发明授权
    Anti-sense oligonucleotides targeted against exon 9 of IL-23Rα gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases 有权
    针对IL-23Rα基因外显子9的反义寡核苷酸及其使用方法诱导外显子跳跃和治疗炎症性肠病

    公开(公告)号：US08618070B2

    公开(公告)日：2013-12-31

    申请号：US13068064

    申请日：2011-05-02

    Applicant: Grant Gallagher ,  Raymond Yu ,  Jonathan Brazaitis

    Inventor： Grant Gallagher ,  Raymond Yu ,  Jonathan Brazaitis

    IPC: C12N15/11

    CPC classification number: C07K14/7155 ,  A61K31/7088 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/33

    Abstract: The present invention relates to anti-sense oligonucleotides (AONs) used to induce exon 9 skipping in IL-23Rα gene. Exon 9 skipping of the IL23Rα gene ultimately causes specific induction of a novel soluble truncated IL-23Rα (Δ9) protein, characterized by a lack in a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end as a result of frame-shift. The present invention provides a utility application of the use of AONs to induce production of a Δ9 protein which inhibits IL-23R-mediated cell signaling. More particularly, Δ9 protein blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of AONs in treating a mammal such as a human patient inflicted with Crohn's disease.

    Abstract translation: 本发明涉及用于诱导IL-23Rα基因突变的外显子9的反义寡核苷酸（AON）。 IL23Ralpha基因的外显子9跳跃最终导致新型可溶性截短的IL-23Rα（Delta9）蛋白的特异性诱导，其特征在于缺少跨膜结构域，并且在其C末端具有独特的8（8）个氨基酸（GLKEGSYC） 作为帧移的结果。 本发明提供了使用AON诱导抑制IL-23R介导的细胞信号传导的Delta9蛋白的生产的实用应用。 更具体地，Delta9蛋白质阻断STAT3形成以及Th17成熟。 提供了AON治疗哺乳动物如患有克罗恩病的人类患者的治疗应用。

    Anti-sense oligonucleotides targeted against exon 9 of IL-23R alpha gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases
    4.
    发明申请
    Anti-sense oligonucleotides targeted against exon 9 of IL-23R alpha gene and method of using same to induce exon skipping and to treat inflammatory bowel diseases 有权
    针对IL-23Rα基因外显子9的反义寡核苷酸及其使用方法诱导外显子跳跃和治疗炎症性肠病

    公开(公告)号：US20130035365A1

    公开(公告)日：2013-02-07

    申请号：US13068064

    申请日：2011-05-02

    Applicant: Grant Gallagher ,  Raymond Yu ,  Jonathan Brazaitis

    Inventor： Grant Gallagher ,  Raymond Yu ,  Jonathan Brazaitis

    IPC: C07H21/04 ,  A61P1/00 ,  A61K31/7088

    CPC classification number: C07K14/7155 ,  A61K31/7088 ,  C12N15/113 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2320/33

    Abstract: The present invention relates to anti-sense oligonucleotides (AONs) used to induce exon 9 skipping in IL-23Rα gene. Exon 9 skipping of the IL23Rα gene ultimately causes specific induction of a novel soluble truncated IL-23Rα (Δ9) protein, characterized by a lack in a transmembrane domain and has a unique eight (8) amino acids (GLKEGSYC) at its C-terminus end as a result of frame-shift. The present invention provides a utility application of the use of AONs to induce production of a Δ9 protein which inhibits IL-23R-mediated cell signaling. More particularly, Δ9 protein blocks STAT3 formation as well as Th17 maturation. There is provided a therapeutic application of AONs in treating a mammal such as a human patient inflicted with Crohn's disease.

    Abstract translation: 本发明涉及用于诱导IL-23Rα基因中外显子9跳跃的反义寡核苷酸（AON）。 IL23Rα基因的外显子9跳跃最终导致新型可溶性截短的IL-23Rα（＆Dgr; 9）蛋白的特异性诱导，其特征在于缺乏跨膜结构域，并且在其C处具有独特的8（8）个氨基酸（GLKEGSYC） 由于帧转移，终端结束。 本发明提供了使用AON来诱导抑制IL-23R介导的细胞信号传导的“Dgr”9蛋白的生产应用。 更具体地，＆Dgr; 9蛋白质阻断STAT3形成以及Th17成熟。 提供了AON治疗哺乳动物如患有克罗恩病的人类患者的治疗应用。

    Novel Polypeptides That Bound to IL-23 Receptor and Inhibit Binding of IL-23 and Cell Signaling Thereof
    5.
    发明申请
    Novel Polypeptides That Bound to IL-23 Receptor and Inhibit Binding of IL-23 and Cell Signaling Thereof 有权
    与IL-23受体结合并抑制IL-23和细胞信号传导的结合的新型多肽

    公开(公告)号：US20130029907A1

    公开(公告)日：2013-01-31

    申请号：US13523286

    申请日：2012-06-14

    Applicant: Grant Gallagher ,  Raymond Yu ,  Jonathan Brazaitis

    Inventor： Grant Gallagher ,  Raymond Yu ,  Jonathan Brazaitis

    IPC: A61K38/10 ,  C07K7/06 ,  C12N5/07 ,  A61P1/00 ,  A61P17/06 ,  C07K7/64 ,  C07K7/08 ,  A61K38/08

    CPC classification number: C07K14/54 ,  A61K38/20

    Abstract: The present invention relates to novel polypeptides that bind to IL-23 receptor and inhibit the binding of IL-23 to its corresponding receptor and cell signaling thereof. The novel polypeptides of the present invention has a core structure of WX1X2X3W, where W is tryptophan, and X1, X2 and X3 are amino acids, with the proviso that when one of X1, X2 or X3 is W, the remaining two of X1, X2 or X3 cannot be W. The present invention relates a composition containing the novel polypeptides, and use of same in treating IL-23 associated human diseases including, for example, inflammatory bowel diseases, psoriasis and Crohn's disease.

    Abstract translation: 本发明涉及结合IL-23受体并抑制IL-23与其相应受体和细胞信号传导的结合的新型多肽。 本发明的新型多肽具有WX1X2X3W的核心结构，其中W是色氨酸，X 1，X 2和X 3是氨基酸，条件是当X 1，X 2或X 3中的一个为W时，X 1， X2或X3不能为W.本发明涉及含有新多肽的组合物及其在治疗IL-23相关人类疾病中的应用，包括例如炎症性肠病，牛皮癣和克罗恩病。

    Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases
    7.
    发明申请
    Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases 有权
    人IL-23受体（IL-23R）mRNA的剪接变体和δ9同种型在预测炎症性肠病中的应用

    公开(公告)号：US20090311694A1

    公开(公告)日：2009-12-17

    申请号：US12386146

    申请日：2009-04-14

    Applicant: Grant Gallagher ,  Raymond Yu ,  Shih-hsin Kan ,  Giacomo Mancini

    Inventor： Grant Gallagher ,  Raymond Yu ,  Shih-hsin Kan ,  Giacomo Mancini

    IPC: C12Q1/68 ,  C07H21/02

    CPC classification number: C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Δ9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Δ9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Δ9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Δ9 isoform of IL-23R.

    Abstract translation: 公开了由人IL-23R mRNA的选择性剪接引起的人IL-23R剪接变体的克隆和鉴定。 通过在IL-23R基因内跳过一个，多个完整外显子或部分外显子，发生替代的mRNA形式。 共鉴定了25种不同的IL-23R转录物。 公开了白细胞介素23受体中的新型外显子缺失（外显子9）同种型，表示为Delta9。 本申请还描述了用于测量不同IL-23R同种型的定量测定。 检测IL-23R的Delta9同种型主要存在于结肠和子宫颈组织中。 在Crohn患者的发炎结肠组织中观察到Delta9的减少。 公开了通过测量IL-23R的Delta9同种型来预测克罗恩病的方法。

    Systems and Methods For Providing A Haptic Manipulandum
    8.
    发明申请
    Systems and Methods For Providing A Haptic Manipulandum 有权
    提供触觉麻醉的系统和方法

    公开(公告)号：US20090073124A1

    公开(公告)日：2009-03-19

    申请号：US12272528

    申请日：2008-11-17

    Applicant: George Anastas ,  David W. Bailey ,  Gregory Tashjian ,  Raymond Yu

    Inventor： George Anastas ,  David W. Bailey ,  Gregory Tashjian ,  Raymond Yu

    IPC: G06F3/033

    CPC classification number: G06F3/016 ,  G06F3/03549

    Abstract: Systems and methods for providing a haptic manipulandum are described. In one described system, a lever arm is pivotably coupled to a housing, and configured to apply a processor-controlled force to a substantially-spherical manipulandum to provide a haptic effect. The described system may include a processor in communication with an actuator for providing the haptic effect.

    Abstract translation: 描述了提供触觉操作的系统和方法。 在一个描述的系统中，杠杆臂可枢转地联接到壳体，并且构造成将处理器控制的力施加到基本上为球面的操纵以提供触觉效果。 所描述的系统可以包括与用于提供触觉效果的致动器通信的处理器。

    User interface device
    9.
    发明授权
    User interface device 有权
    用户界面设备

    公开(公告)号：US07456821B2

    公开(公告)日：2008-11-25

    申请号：US10999064

    申请日：2004-11-30

    Applicant: Raymond Yu

    Inventor： Raymond Yu

    IPC: G06F3/033

    CPC classification number: G06F3/0338 ,  G06F3/016

    Abstract: A device comprises a manipulandum moveable in at least two degrees of freedom including a first link rotatably moveable about a pivot axis and a second link rotatably moveable about a pivot axis. The first link and the second link are coupled to a ground member. A first actuator is configured to engage the first link and provide an output about a drive axis of the first actuator. A second actuator is configured to engage the second link and provide an output about a drive axis of the second actuator. The drive axis of the first actuator is substantially parallel to the drive axis of the second actuator. The first actuator and the second actuator are each configured to receive a signal associated with a force feedback. The force feedback being associated with the manipulandum.

    Abstract translation: 一种装置包括可在至少两个自由度中移动的操纵件，包括围绕枢转轴线可旋转地移动的第一连杆和可围绕枢转轴线可旋转地移动的第二连杆。 第一链路和第二链路耦合到接地部件。 第一致动器构造成接合第一连杆并提供围绕第一致动器的驱动轴的输出。 第二致动器构造成接合第二连杆并且提供围绕第二致动器的驱动轴线的输出。 第一致动器的驱动轴基本上平行于第二致动器的驱动轴。 第一致动器和第二致动器均被配置为接收与力反馈相关联的信号。 力反馈与操纵有关。

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