公开(公告)号：US20100190723A1

公开(公告)日：2010-07-29

申请号：US12532765

申请日：2008-03-19

Applicant: Hiroo Sanada ,  Kenji Sato ,  Shin Ono ,  Yoshio Suzuki

Inventor： Hiroo Sanada ,  Kenji Sato ,  Shin Ono ,  Yoshio Suzuki

IPC: A61K38/06 ,  C07K5/08 ,  A61P1/16

CPC classification number: C07K5/0825 ,  A21D2/245 ,  A23L23/00 ,  A23L33/18 ,  A61K38/00 ,  C07K5/06173 ,  C07K5/1024

Abstract: This invention provides a composition having preventive and/or therapeutic effects on liver disease, which is highly effective, free of side effects, easily ingestible, and capable of long-term ingestion from the viewpoint of a cost and safety. This invention relates to a peptide having the amino acid sequence represented by the following formula: pyroGlu-(X)n-A, wherein X is the same or different and represents Gln or Asn; A represents Gln, Asn, Leu, Ile, or Val; and n is an integer from 0 to 2 or a salt thereof.

Abstract translation: 本发明提供一种具有预防和/或治疗对肝脏疾病的作用的组合物，其从成本和安全性的观点来看，其高度有效，无副作用，容易摄取，并且能够长期摄取。 本发明涉及具有下式表示的氨基酸序列的肽：pyroGlu-（X）n-A，其中X相同或不同，表示Gln或Asn; A代表Gln，Asn，Leu，Ile或Val; n为0〜2的整数或其盐。

公开(公告)号：US20110183925A1

公开(公告)日：2011-07-28

申请号：US13120371

申请日：2008-09-22

Applicant: Kenji Sato ,  Shin Ono ,  Yoshio Suzuki

Inventor： Kenji Sato ,  Shin Ono ,  Yoshio Suzuki

IPC: A61K38/05 ,  A61K38/06 ,  C07K5/08 ,  C07C229/00

CPC classification number: C07K5/0819 ,  A61K38/00 ,  C07K5/06104 ,  C07K5/06113

Abstract: Provided is an anti-inflammatory composition which has a high efficacy, causes no concern about side effects, is easy to ingest, and can also be administered for a long period of time because of its low cost and high safety. The present invention relates to a peptide comprising an amino acid sequence represented by pyroGlu-(X)n-A or a salt thereof, wherein X is independently Gln, Asn, or Pro; A represents Gln, Asn, Leu, Ile, Met, Val, or Phe; and n represents an integer of 0 to 2, and an anti-inflammatory composition comprising the same.

Abstract translation: 本发明提供一种抗炎组合物，其效果高，不会引起副作用，容易摄取，并且由于成本低，安全性高，因此也可以长时间给药。 本发明涉及包含由pyroGlu-（X）n-A或其盐表示的氨基酸序列的肽，其中X独立地为Gln，Asn或Pro; A代表Gln，Asn，Leu，Ile，Met，Val或Phe; n表示0〜2的整数，和含有该整数的抗炎组合物。

公开(公告)号：US5916877A

公开(公告)日：1999-06-29

申请号：US911380

申请日：1997-08-14

Applicant: James C. Powers ,  Shin Ono

Inventor： James C. Powers ,  Shin Ono

IPC: A61K38/00 ,  C07K5/02 ,  C07K5/06 ,  A61K38/05

CPC classification number: C07K5/021 ,  C07K5/06191 ,  A61K38/00

Abstract: Fluorescent 1-peptidylaminoalkanephosphonate derivatives, and their use in detecting and studying the distribution of serine proteases in cells and biological systems.

Abstract translation: 荧光1-肽基氨基链烷膦酸衍生物及其在细胞和生物系统中检测和研究丝氨酸蛋白酶分布的用途。