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公开(公告)号：US20140168657A1
公开(公告)日：2014-06-19
申请号：US14116732
申请日：2012-05-09
申请人： Haruo Nakaji , Hidenao Fukuyama , Yuusuke Iso , Shinichi Urayama , Naoya Oishi , Hiroshi Fujiwara
发明人： Haruo Nakaji , Hidenao Fukuyama , Yuusuke Iso , Shinichi Urayama , Naoya Oishi , Hiroshi Fujiwara
CPC分类号： A61B5/0073 , A61B10/0041 , G01B9/02091 , G01N21/4795
摘要： An optical tomography device 1 is provided as one capable of obtaining tomographic information of a measuring object with higher accuracy. In the optical tomography device 1, numerical apertures of reception fibers 12, 13 are different from each other. Therefore, the device has a configuration wherein the reception fibers 12, 13 receive two kinds of respective light beams with different solid angle distributions, whereby the device can also obtain angular information, in addition to intensity information of light emerging from a measuring object 100. As a result, the accuracy is enhanced for an analysis about the tomographic information of the measuring object.
摘要翻译： 光学断层摄影装置1被提供为能够以更高精度获得测量对象的断层图像信息的装置。 在光学断层摄影装置1中，接收光纤12,13的数值孔径彼此不同。 因此，该装置具有其中接收光纤12,13接收具有不同立体角分布的两种各自的光束的配置，由此除了从测量对象100出射的光的强度信息之外，该装置还可以获得角度信息。 因此，对于关于测量对象的断层信息的分析，精度被增强。
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公开(公告)号：US08609871B2
公开(公告)日：2013-12-17
申请号：US13597361
申请日：2012-08-29
IPC分类号： C07D307/92
CPC分类号： C07D307/77 , A61K31/343 , C07D307/80 , C07D307/81
摘要： An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.
摘要翻译： 一种以高产率生产高纯度光学活性胺衍生物同时抑制副产物形成的工业方法，其包括使（E）-2-（1,6,7,8-四氢-2H-茚并[5 ，4-b]呋喃-8-亚基）乙胺进行不对称还原，在40〜100℃的反应温度和3〜9的pH下催化还原得到的（S）-2-（ 1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基）乙胺进行丙酰化，然后使反应混合物结晶。
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公开(公告)号：US20090036521A1
公开(公告)日：2009-02-05
申请号：US11662684
申请日：2005-09-12
IPC分类号： C07D307/93 , A61K31/343 , A61P25/20
CPC分类号： C07D307/77 , A61K31/343 , C07D307/80 , C07D307/81
摘要： An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.
摘要翻译： 一种以高产率生产高纯度光学活性胺衍生物同时抑制副产物形成的工业方法，其包括使（E）-2-（1,6,7,8-四氢-2H-茚并[5 ，4-b]呋喃-8-亚基）乙胺进行不对称还原，在40〜100℃的反应温度和3〜9的pH下催化还原得到的（S）-2-（ 1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基）乙胺进行丙酰化，然后使反应混合物结晶。
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公开(公告)号：US09179842B2
公开(公告)日：2015-11-10
申请号：US14116732
申请日：2012-05-09
申请人： Haruo Nakaji , Hidenao Fukuyama , Yuusuke Iso , Shinichi Urayama , Naoya Oishi , Hiroshi Fujiwara
发明人： Haruo Nakaji , Hidenao Fukuyama , Yuusuke Iso , Shinichi Urayama , Naoya Oishi , Hiroshi Fujiwara
CPC分类号： A61B5/0073 , A61B10/0041 , G01B9/02091 , G01N21/4795
摘要： An optical tomography device 1 is provided as one capable of obtaining tomographic information of a measuring object with higher accuracy. In the optical tomography device 1, numerical apertures of reception fibers 12, 13 are different from each other. Therefore, the device has a configuration wherein the reception fibers 12, 13 receive two kinds of respective light beams with different solid angle distributions, whereby the device can also obtain angular information, in addition to intensity information of light emerging from a measuring object 100. As a result, the accuracy is enhanced for an analysis about the tomographic information of the measuring object.
摘要翻译： 光学断层摄影装置1被提供为能够以更高精度获得测量对象的断层图像信息的装置。 在光学断层摄影装置1中，接收光纤12,13的数值孔径彼此不同。 因此，该装置具有其中接收光纤12,13接收具有不同立体角分布的两种各自的光束的配置，由此除了从测量对象100出射的光的强度信息之外，该装置还可以获得角度信息。 因此，对于关于测量对象的断层信息的分析，精度被增强。
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公开(公告)号：US20130079397A1
公开(公告)日：2013-03-28
申请号：US13597361
申请日：2012-08-29
IPC分类号： C07D307/81 , A61K31/343
CPC分类号： C07D307/77 , A61K31/343 , C07D307/80 , C07D307/81
摘要： An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.
摘要翻译： 一种以高产率生产高纯度光学活性胺衍生物同时抑制副产物形成的工业方法，其包括使（E）-2-（1,6,7,8-四氢-2H-茚并[5 ，4-b]呋喃-8-亚基）乙胺进行不对称还原，在40〜100℃的反应温度和3〜9的pH下催化还原得到的（S）-2-（ 1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基）乙胺进行丙酰化，然后使反应混合物结晶。
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公开(公告)号：US20120088826A1
公开(公告)日：2012-04-12
申请号：US13325946
申请日：2011-12-14
IPC分类号： A61K31/343 , A61P25/20 , C07D307/77
CPC分类号： C07D307/77 , A61K31/343 , C07D307/80 , C07D307/81
摘要： An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.
摘要翻译： 一种以高产率生产高纯度光学活性胺衍生物同时抑制副产物形成的工业方法，其包括使（E）-2-（1,6,7,8-四氢-2H-茚并[5 ，4-b]呋喃-8-亚基）乙胺进行不对称还原，在40〜100℃的反应温度和3〜9的pH下催化还原得到的（S）-2-（ 1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基）乙胺进行丙酰化，然后使反应混合物结晶。
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公开(公告)号：US08097737B2
公开(公告)日：2012-01-17
申请号：US11662684
申请日：2005-09-12
IPC分类号： C07D307/93
CPC分类号： C07D307/77 , A61K31/343 , C07D307/80 , C07D307/81
摘要： An industrial process for production of high-purity optically active amine derivatives in high yield while inhibiting the formation of by-products, which comprises subjecting (E)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine to asymmetric reduction, catalytically reducing the obtained product at a reaction temperature of 40 to 100° C. and a pH of 3 to 9, subjecting the obtained (S)-2-(1,6,7,8-tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylamine to propionylation, and then crystallizing the reaction mixture.
摘要翻译： 一种以高产率生产高纯度光学活性胺衍生物同时抑制副产物形成的工业方法，其包括使（E）-2-（1,6,7,8-四氢-2H-茚并[5 ，4-b]呋喃-8-亚基）乙胺进行不对称还原，在40〜100℃的反应温度和3〜9的pH下催化还原得到的（S）-2-（ 1,6,7,8-四氢-2H-茚并[5,4-b]呋喃-8-基）乙胺进行丙酰化，然后使反应混合物结晶。
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