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1.发明申请INFLUENZA B VIRUSES WITH REDUCED SENSITIVITY TO NEURAMINIDASE INHIBITORS 有权具有降低对神经酰胺糖苷酶抑制剂敏感性的流感病毒B病毒公开(公告)号：US20080293040A1
公开(公告)日：2008-11-27
申请号：US12058389
申请日：2008-03-28
CPC分类号： C07K14/005 , A61K35/13 , C12N7/00 , C12N2760/16221 , C12N2760/16222 , G01N2333/11
摘要： An isolated influenza B virus which has reduced sensitivity to one or more neuraminidase (NA) inhibitors, wherein the reduced sensitivity to one or more NA inhibitors is associated with a residue in NA other than Ile at position 222, a residue in NA other than Ser at a position 250, or a residue in NA other than Gly at position 402, as well as methods to detect such a virus or determine agents that inhibit the infection or replication of such as virus, are provided.
摘要翻译： 一种对一种或多种神经氨酸酶（NA）抑制剂的敏感性降低的分离的乙型流感病毒，其中对一种或多种NA抑制剂的敏感性降低与位于第222位的Ile以外的NA中的残基相关，NA以外的残基 在位置250处，或者在位置402处的除了Gly之外的NA中的残基，以及检测这种病毒或确定抑制诸如病毒的感染或复制的试剂的方法。
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2.发明授权公开(公告)号：US07191625B2
公开(公告)日：2007-03-20
申请号：US11180914
申请日：2005-07-14
申请人： Hidetaka Yahagi , Shuji Hatakeyama
发明人： Hidetaka Yahagi , Shuji Hatakeyama
IPC分类号： B21C43/02
CPC分类号： G03G5/005 , G03G5/102 , G03G15/751
摘要： A method of cleaning an aluminum drum substrate that removes cutting chips, and degreases to remove high viscosity drawing oil used in a cold drawing process, without using a chlorine-containing organic solvent. A plurality of aluminum drum substrates are arranged in rows, with an axis of each drum substrate being vertical and parallel with the axis of the other drum substrates. A cleaning liquid is ejected at a predetermined ejection pressure from a high-pressure cleaning nozzle. The cleaning liquid is ejected in a fan shape having a predetermined spread angle and from above a top opening of one of the drum substrates towards the drum substrate. While ejecting the cleaning liquid, the nozzle is horizontally and sequentially traversed above openings of the other drum substrates in a direction of the row, while swinging the nozzle in the direction of the row.
摘要翻译： 在不使用含氯有机溶剂的情况下，清洗除去切屑的铝鼓基材的清洗方法，脱脂以除去冷拉伸工序中使用的高粘度拉伸油。 多个铝鼓基板排列成一列，每个鼓基板的轴线垂直并与另一个鼓底板的轴线平行。 从高压清洗喷嘴以预定的喷射压力喷射清洗液。 清洗液以具有预定扩展角的风扇形式从其中一个滚筒基板的顶部开口朝向滚筒基板喷射。 在喷射清洗液体的同时，喷嘴沿着行的方向水平顺序地横过另一个鼓基板的开口，同时使喷嘴沿着行的方向摆动。
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3.发明授权公开(公告)号：US08465960B2
公开(公告)日：2013-06-18
申请号：US12058389
申请日：2008-03-28
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , A61K35/13 , C12N7/00 , C12N2760/16221 , C12N2760/16222 , G01N2333/11
摘要： An isolated influenza B virus which has reduced sensitivity to one or more neuraminidase (NA) inhibitors, wherein the reduced sensitivity to one or more NA inhibitors is associated with a residue in NA other than Ile at position 222, a residue in NA other than Ser at a position 250, or a residue in NA other than Gly at position 402, as well as methods to detect such a virus or determine agents that inhibit the infection or replication of such as virus, are provided.
摘要翻译： 一种对一种或多种神经氨酸酶（NA）抑制剂的敏感性降低的分离的乙型流感病毒，其中对一种或多种NA抑制剂的敏感性降低与位于第222位的Ile以外的NA中的残基相关，NA以外的残基 在位置250处，或者在位置402处的除了Gly之外的NA中的残基，以及检测这种病毒或确定抑制诸如病毒的感染或复制的试剂的方法。
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4.发明申请公开(公告)号：US20060010950A1
公开(公告)日：2006-01-19
申请号：US11180914
申请日：2005-07-14
申请人： Hidetaka Yahagi , Shuji Hatakeyama
发明人： Hidetaka Yahagi , Shuji Hatakeyama
IPC分类号： B21D51/26
CPC分类号： G03G5/005 , G03G5/102 , G03G15/751
摘要： A method of cleaning an aluminum drum substrate that removes cutting chips, and degreases to remove high viscosity drawing oil used in a cold drawing process, without using a chlorine-containing organic solvent. A plurality of aluminum drum substrates are arranged in rows, with an axis of each drum substrate being vertical and parallel with the axis of the other drum substrates. A cleaning liquid is ejected at a predetermined ejection pressure from a high-pressure cleaning nozzle. The cleaning liquid is ejected in a fan shape having a predetermined spread angle and from above a top opening of one of the drum substrates towards the drum substrate. While ejecting the cleaning liquid, the nozzle is horizontally and sequentially traversed above openings of the other drum substrates in a direction of the row, while swinging the nozzle in the direction of the row.
摘要翻译： 在不使用含氯有机溶剂的情况下，清洗除去切屑的铝鼓基材的清洗方法，脱脂以除去冷拉伸工序中使用的高粘度拉伸油。 多个铝鼓基板排列成一列，每个鼓基板的轴线垂直并与另一个鼓底板的轴线平行。 从高压清洗喷嘴以预定的喷射压力喷射清洗液。 清洗液以具有预定扩展角的风扇形式从其中一个滚筒基板的顶部开口朝向滚筒基板喷射。 在喷射清洗液体的同时，喷嘴沿着行的方向水平顺序地横过另一个鼓基板的开口，同时使喷嘴沿着行的方向摆动。
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