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1.发明申请CONJUGATE COMPRISING ANGIOSTATION OR ITS FRAGMENT, THE METHOD FOR PRODUCING THE CONJUGATE AND USE THEREOF 审中-公开包含放射性物质或其碎片的方法，其生产方法和使用方法公开(公告)号：US20100184661A1
公开(公告)日：2010-07-22
申请号：US12522661
申请日：2008-01-10
Applicant: Yongzhang Luo , Guodong Chang , Shuling Yang , Lei Gao , Yan Fu
Inventor： Yongzhang Luo , Guodong Chang , Shuling Yang , Lei Gao , Yan Fu
CPC classification number: A61K47/60 , C12N9/6435 , C12Y304/21007
Abstract: The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms.
Abstract translation: 本发明提供抗肿瘤或抗血管生成药物，含有该药物的组合物或试剂盒及其制备方法。 抗肿瘤或抗血管生成药物含有包含修饰剂和血管抑素或其片段的缀合物，其中与未修饰的血管抑素或其片段相比，缀合物表现出延长的体内半衰期。 改性剂选自高分子聚合物，蛋白质分子或其片段，肽，小分子或任何其它形式的化学物质。
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2.发明申请CONJUGATE ANGIOSTATION OR ITS FRAGMENT, THE METHOD OF PRODUCING THE CONJUGATE AND USE THEREOF 审中-公开联合攻击或其碎片，生产和使用它们的方法公开(公告)号：US20140056966A1
公开(公告)日：2014-02-27
申请号：US13488932
申请日：2012-06-05
Applicant: Yongzhang LUO , Guodong Chang , Shuling Yang , Lei Gao , Yan Fu
Inventor： Yongzhang LUO , Guodong Chang , Shuling Yang , Lei Gao , Yan Fu
IPC: A61K47/48
CPC classification number: A61K47/60 , C12N9/6435 , C12Y304/21007
Abstract: The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms.
Abstract translation: 本发明提供抗肿瘤或抗血管生成药物，含有该药物的组合物或试剂盒及其制备方法。 抗肿瘤或抗血管生成药物含有包含修饰剂和血管抑素或其片段的缀合物，其中与未修饰的血管抑素或其片段相比，缀合物表现出延长的体内半衰期。 改性剂选自高分子聚合物，蛋白质分子或其片段，肽，小分子或任何其它形式的化学物质。
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