CONJUGATE COMPRISING ANGIOSTATION OR ITS FRAGMENT, THE METHOD FOR PRODUCING THE CONJUGATE AND USE THEREOF
    1.
    发明申请
    CONJUGATE COMPRISING ANGIOSTATION OR ITS FRAGMENT, THE METHOD FOR PRODUCING THE CONJUGATE AND USE THEREOF 审中-公开
    包含放射性物质或其碎片的方法,其生产方法和使用方法

    公开(公告)号:US20100184661A1

    公开(公告)日:2010-07-22

    申请号:US12522661

    申请日:2008-01-10

    摘要: The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms.

    摘要翻译: 本发明提供抗肿瘤或抗血管生成药物,含有该药物的组合物或试剂盒及其制备方法。 抗肿瘤或抗血管生成药物含有包含修饰剂和血管抑素或其片段的缀合物,其中与未修饰的血管抑素或其片段相比,缀合物表现出延长的体内半衰期。 改性剂选自高分子聚合物,蛋白质分子或其片段,肽,小分子或任何其它形式的化学物质。

    CONJUGATE ANGIOSTATION OR ITS FRAGMENT, THE METHOD OF PRODUCING THE CONJUGATE AND USE THEREOF
    2.
    发明申请
    CONJUGATE ANGIOSTATION OR ITS FRAGMENT, THE METHOD OF PRODUCING THE CONJUGATE AND USE THEREOF 审中-公开
    联合攻击或其碎片,生产和使用它们的方法

    公开(公告)号:US20140056966A1

    公开(公告)日:2014-02-27

    申请号:US13488932

    申请日:2012-06-05

    IPC分类号: A61K47/48

    摘要: The present invention provides an anti-tumor or anti-angiogenesis medicament, the combination or kit containing the medicament, and the method for producing the same. The anti-tumor or anti-angiogenesis medicament contains a conjugate comprising a modifying agent and the angiostatin or its fragments, wherein the conjugate exhibits prolonged in vivo half-life as compared to an unmodified angiostatin or its fragments. The modifying agent is selected from the group consisting of macromolecular polymers, protein molecules or fragments thereof, peptides, small molecules, or chemical substances of any other forms.

    摘要翻译: 本发明提供抗肿瘤或抗血管生成药物,含有该药物的组合物或试剂盒及其制备方法。 抗肿瘤或抗血管生成药物含有包含修饰剂和血管抑素或其片段的缀合物,其中与未修饰的血管抑素或其片段相比,缀合物表现出延长的体内半衰期。 改性剂选自高分子聚合物,蛋白质分子或其片段,肽,小分子或任何其它形式的化学物质。

    Copier/printer exterior part using halogen-free flame-retardant resin composition including recycled polycarbonate and recycled polyethylene terephthalate
    4.
    发明授权
    Copier/printer exterior part using halogen-free flame-retardant resin composition including recycled polycarbonate and recycled polyethylene terephthalate 有权
    使用无卤阻燃树脂组合物的复印机/打印机外部部件,包括再循环聚碳酸酯和回收的聚对苯二甲酸乙二醇酯

    公开(公告)号:US08865795B1

    公开(公告)日:2014-10-21

    申请号:US14302633

    申请日:2014-06-12

    IPC分类号: C08K5/521 C08L69/00 C08L67/02

    摘要: A copier/printer exterior part uses a halogen-free flame-retardant resin composition. The halogen-free flame-retardant resin composition includes 5 wt % to 50 wt % of unused polycarbonate, 20 wt % to 63 wt % of recycled polycarbonate, 5 wt % to 35 wt % of recycled polyethylene terephthalate, 0.2 wt % to 2 wt % of a styrene-acrylonitrile-glycidyl methacrylate terpolymer, 5 wt % to 15 wt % of a toughener, 10 wt % to 20 wt % of a flame retardant, 0.1 wt % to 0.8 wt % of a flame-retardant antidrip agent, 0.1 wt % to 1 wt % of an antioxidant, and 0.1 wt % to 2 wt % of a lubricant. The styrene-acrylonitrile-glycidyl methacrylate terpolymer includes 1 wt % to 5 wt % of glycidyl methacrylate and 20 wt % to 33 wt % of acrylonitrile.

    摘要翻译: 复印机/打印机外部部件使用无卤阻燃树脂组合物。 无卤阻燃树脂组合物包含5重量%至50重量%的未使用聚碳酸酯,20重量%至63重量%的再循环聚碳酸酯,5重量%至35重量%的再循环聚对苯二甲酸乙二醇酯,0.2重量%至2重量% %的苯乙烯 - 丙烯腈 - 甲基丙烯酸缩水甘油酯三元共聚物,5重量%〜15重量%的增韧剂,10重量%〜20重量%的阻燃剂,0.1重量%〜0.8重量%的阻燃抗蚀剂,0.1 重量%至1重量%的抗氧化剂和0.1重量%至2重量%的润滑剂。 苯乙烯 - 丙烯腈 - 甲基丙烯酸缩水甘油酯三元共聚物包括1重量%至5重量%的甲基丙烯酸缩水甘油酯和20重量%至33重量%的丙烯腈。

    MIDDLEWARE DATA LOG SYSTEM
    5.
    发明申请
    MIDDLEWARE DATA LOG SYSTEM 有权
    MIDDLEWARE数据记录系统

    公开(公告)号:US20120215740A1

    公开(公告)日:2012-08-23

    申请号:US13296894

    申请日:2011-11-15

    IPC分类号: G06F17/30

    CPC分类号: G06F17/30578

    摘要: A method of maintaining a data store is disclosed. The data store is distributed across a plurality of storage provider instances, including a master storage provider instance and a plurality of additional storage provider instances. A master data log is updated to reflect a change to the data store. The master data log is synchronized with a plurality of replicas of the master data log. The change is propagated across the plurality of additional storage provider instances based on an analysis of the replicas.

    摘要翻译: 公开了维护数据存储的方法。 数据存储分布在多个存储提供者实例之间,包括主存储提供者实例和多个附加的存储提供者实例。 更新主数据日志以反映对数据存储的更改。 主数据日志与主数据日志的多个副本同步。 基于对副本的分析,更改在多个附加存储提供商实例之间传播。

    STABLE FUNCTIONAL BEVERAGE COMPOSITIONS AND METHODS OF MAKING SAME
    6.
    发明申请
    STABLE FUNCTIONAL BEVERAGE COMPOSITIONS AND METHODS OF MAKING SAME 审中-公开
    稳定的功能性饮料组合物及其制备方法

    公开(公告)号:US20120058240A1

    公开(公告)日:2012-03-08

    申请号:US13320168

    申请日:2010-05-14

    摘要: The invention relates to processes for manufacturing stable functional protein-containing beverage compositions, such as dairy-based beverages. A functional ingredient, such as yeast beta-glucan, is stabilized in the protein-containing composition by subjecting the composition to intense agitation, e.g. homogenization or sonication. Advantageously, these processes permits heat-treatment of the functional beverage composition for extended shelf-life of the final product. Stable functional beverage compositions prepared by these processes are also provided.

    摘要翻译: 本发明涉及制备含稳定功能蛋白的饮料组合物如乳制饮料的方法。 功能成分,如酵母β-葡聚糖,通过对组合物进行剧烈搅拌,例如, 均质化或超声处理。 有利地,这些方法允许功能性饮料组合物的热处理延长最终产品的保质期。 还提供了通过这些方法制备的稳定的功能性饮料组合物。

    Reconfiguring Propagation Streams in Distributed Information Sharing
    7.
    发明申请
    Reconfiguring Propagation Streams in Distributed Information Sharing 有权
    在分布式信息共享中重新构建传播流

    公开(公告)号:US20090037442A1

    公开(公告)日:2009-02-05

    申请号:US11831798

    申请日:2007-07-31

    IPC分类号: G06F17/30

    CPC分类号: G06F17/30575

    摘要: Splitting and merging database object information sharing streams. Streams are also referred to herein as “propagations”. Splitting and merging information sharing streams can be used to improve performance in a information sharing environment when a failed or slow DBS impacts the performance. In one embodiment, an auto split process monitors the progress of applying changes at each node and detects the presence of a failed or a slow node. Once the failed or slow node is identified, the auto split process splits the propagation such that the offending node is sent through a separate propagation. Furthermore, an auto merge process can be started to monitor the newly created separate propagation. At a later point, the new propagation can be merged back into the original stream. For example, if the offending node catches up with other nodes, the auto merge process merges the newly created propagation back to the original propagation.

    摘要翻译: 分割和合并数据库对象信息共享流。 流在本文中也称为“传播”。 当失败或缓慢的DBS影响性能时,可以使用分割和合并信息共享流来提高信息共享环境中的性能。 在一个实施例中,自动拆分过程监视在每个节点处应用变化的进度,并检测故障或慢节点的存在。 一旦确定了故障或慢节点,自动拆分过程就会分裂传播,从而通过单独的传播发送违规节点。 此外,可以开始自动合并处理来监视新创建的单独传播。 稍后,新的传播可以合并回原始流。 例如,如果违规节点赶上其他节点,则自动合并过程将新创建的传播合并到原始传播。

    COMBINING CAPTURE AND APPLY IN A DISTRIBUTED INFORMATION SHARING SYSTEM
    8.
    发明申请
    COMBINING CAPTURE AND APPLY IN A DISTRIBUTED INFORMATION SHARING SYSTEM 有权
    组合捕获并应用于分布式信息共享系统

    公开(公告)号:US20090037422A1

    公开(公告)日:2009-02-05

    申请号:US11831478

    申请日:2007-07-31

    IPC分类号: G06F17/30

    CPC分类号: G06F17/30575

    摘要: In accordance with an embodiment of the present invention, an information sharing mechanism comprising a memory structure may be provided in a database system. In an embodiment, mined information transferred by a capture process to an associated apply process can be written into the memory structure without taking any latch. Similarly, the mined information can be read by the apply process from the memory structure without taking any latch. The capture and apply processes may work cooperatively to establish a safe point in log mining under various circumstances such as in an initial startup state, in a steady state, in a process restart scenario in the middle of information sharing. In some embodiments, the information sharing mechanism supports both checkpoint-free and checkpoint modes of log mining by the capture process. In addition, both the capture process and the apply process may employ an eager apply approach to increase processing capacity.

    摘要翻译: 根据本发明的实施例,可以在数据库系统中提供包括存储器结构的信息共享机制。 在一个实施例中,通过捕获处理传送到相关联的应用进程的挖掘信息可以被写入存储器结构而不采取任何锁存。 类似地,可以通过应用处理从存储器结构读取挖掘的信息,而不采取任何锁存。 捕获和应用过程可以协同工作,在各种情况下在日志挖掘中建立安全点,例如在初始启动状态,稳定状态下,在信息共享过程中的过程重新启动情况。 在一些实施例中,信息共享机制通过捕获过程支持日志挖掘的无检点和检查点模式。 此外,捕获过程和应用过程都可以采用渴望应用的方法来增加处理能力。

    Systems and methods for content-aware load balancing
    9.
    发明申请
    Systems and methods for content-aware load balancing 审中-公开
    内容感知负载均衡的系统和方法

    公开(公告)号:US20060224773A1

    公开(公告)日:2006-10-05

    申请号:US11094905

    申请日:2005-03-31

    IPC分类号: G06F15/173

    摘要: Improved load balancing techniques are disclosed. For example, in one illustrative aspect of the invention, a method of satisfying requests in a system comprised of a plurality of servers comprises the following steps. At least one load balancer is provided for routing requests to the plurality of servers. At the at least one load balancer, a request sent from a client is obtained. At the at least one load balancer, the request is examined. Costs of satisfying the request by at least two of the plurality of servers are estimated. The estimation is based on at least one of a number and a cost of at least one remote access for satisfying the request. The request is routed to a server of the plurality of servers with a low estimated cost of satisfying the request.

    摘要翻译: 公开了改进的负载平衡技术。 例如,在本发明的一个说明性方面,在由多个服务器构成的系统中满足请求的方法包括以下步骤。 提供至少一个负载平衡器用于将请求路由到多个服务器。 在至少一个负载均衡器上,获得从客户端发送的请求。 在至少一个负载均衡器上,检查该请求。 估计满足多个服务器中的至少两个的请求的成本。 该估计基于用于满足该请求的至少一个远程访问的数量和成本中的至少一个。 以满足请求的低估计成本将该请求路由到多个服务器的服务器。

    Checkpoint-free in log mining for distributed information sharing
    10.
    发明授权
    Checkpoint-free in log mining for distributed information sharing 有权
    日志挖掘中使用无检查点进行分布式信息共享

    公开(公告)号:US09009104B2

    公开(公告)日:2015-04-14

    申请号:US12853991

    申请日:2010-08-10

    IPC分类号: G06F17/30

    CPC分类号: G06F17/30368

    摘要: Techniques for replicating data between database systems without taking checkpoints are provided. In an embodiment, a capture process restarts. Upon restarting, the capture process reestablishes an association with an apply process. A particular logical time maintained by the apply process is then communicated to the capture process. Upon receiving the particular logical time, the capture process restarts mining from this particular logical time.

    摘要翻译: 提供了在不使用检查点的情况下在数据库系统之间复制数据的技术。 在一个实施例中,捕获过程重新启动。 重新启动后,捕获进程重新建立与应用进程的关联。 然后将应用过程维护的特定逻辑时间传达给捕获进程。 在接收到特定的逻辑时间之后,捕获过程从该特定逻辑时间重新启动挖掘。