公开(公告)号：US09242950B2

公开(公告)日：2016-01-26

申请号：US13538189

申请日：2012-06-29

申请人： Tatsuya Matsukawa ,  Noriyuki Yamamoto ,  Ryuji Ueno ,  Hiroyuki Kotajima ,  Shunsuke Fukuya ,  Michiharu Handa ,  Katsuya Sakata

发明人： Tatsuya Matsukawa ,  Noriyuki Yamamoto ,  Ryuji Ueno ,  Hiroyuki Kotajima ,  Shunsuke Fukuya ,  Michiharu Handa ,  Katsuya Sakata

IPC分类号： C07D307/30

CPC分类号： C07D307/30 ,  Y02P20/55

摘要： A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.

摘要翻译： 提供一种制备式（I）表示的脂肪酸衍生物的方法：其中Z 1是其中R 3是羟基的保护基; 其包括使式（II）化合物：其中Z2与Z 1相同，除了当Z 1为Z 2时，其为与氧化剂在氮杂金刚烷-N-氧基衍生物存在下反应的步骤。

公开(公告)号：US08389738B2

公开(公告)日：2013-03-05

申请号：US13002837

申请日：2009-07-09

申请人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

发明人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

IPC分类号： C07D261/04

CPC分类号： C07D261/04

摘要： A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, C1-6 haloalkyl, etc., Y is a halogen atom, C1-6 alkyl, etc., R1 is a C1-6 haloalkyl, etc., R2 and R3 independently of each other are a hydrogen atom, C1-6 alkyl, etc., R4 is C1-6 alkyl, C1-6 haloalkyl, etc., R5 is a hydrogen atom, c1-6 alkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R1, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, —C(O)OH, —C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R2, R3, R4, and R5 are the same as defined above, or a salt thereof; crystal forms and the production method thereof.

摘要翻译： 其中X是卤素原子，C 1-6卤代烷基等的式（1）的异恶唑啉取代的苯甲酸酰胺化合物的制备方法，Y是卤素原子，C 1-6烷基等，R 1是C 1 -6卤代烷基等，R2和R3彼此独立地是氢原子，C1-6烷基等，R4是C1-6烷基，C1-6卤代烷基等，R5是氢原子，c1- 6烷基等，m为0〜5的整数，n为0〜4的整数，包括：使式（3）的异恶唑啉取代的苯化合物，其中X，Y，R 1，m和n分别为 与上述相同，L是氯原子，溴原子，-C（O）OH，-C（O）J等，J是卤素原子，与式（2）的2-氨基乙酰胺化合物 2）其中R2，R3，R4和R5与上述定义相同，或其盐; 晶体形式及其制备方法。

公开(公告)号：US20110144349A1

公开(公告)日：2011-06-16

申请号：US13002837

申请日：2009-07-09

申请人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

发明人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

IPC分类号： C07D261/04

CPC分类号： C07D261/04

摘要： A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, C1-6 haloalkyl, etc., Y is a halogen atom, C1-6 alkyl, etc., R1 is a C1-6 haloalkyl, etc., R2 and R3 independently of each other are a hydrogen atom, C1-6 alkyl, etc., R4 is C1-6 alkyl, C1-6 haloalkyl, etc., R5 is a hydrogen atom, c1-6 alkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R1, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, —C(O)OH, —C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R2, R3, R4, and R5 are the same as defined above, or a salt thereof; crystal forms and the production method thereof.

摘要翻译： 其中X是卤素原子，C 1-6卤代烷基等的式（1）的异恶唑啉取代的苯甲酸酰胺化合物的制备方法，Y是卤素原子，C 1-6烷基等，R 1是C 1 -6卤代烷基等，R2和R3彼此独立地是氢原子，C1-6烷基等，R4是C1-6烷基，C1-6卤代烷基等，R5是氢原子，c1- 6烷基等，m为0〜5的整数，n为0〜4的整数，包括：使式（3）的异恶唑啉取代的苯化合物，其中X，Y，R 1，m和n分别为 与上述相同，L是氯原子，溴原子，-C（O）OH，-C（O）J等，J是卤素原子，与式（2）的2-氨基乙酰胺化合物 2）其中R2，R3，R4和R5与上述定义相同，或其盐; 晶体形式及其制备方法。

公开(公告)号：US20130005995A1

公开(公告)日：2013-01-03

申请号：US13538189

申请日：2012-06-29

申请人： Tatsuya MATSUKAWA ,  Noriyuki YAMAMOTO ,  Ryuji UENO ,  Hiroyuki KOTAJIMA ,  Shunsuke FUKUYA ,  Michiharu HANDA ,  Katsuya SAKATA

发明人： Tatsuya MATSUKAWA ,  Noriyuki YAMAMOTO ,  Ryuji UENO ,  Hiroyuki KOTAJIMA ,  Shunsuke FUKUYA ,  Michiharu HANDA ,  Katsuya SAKATA

IPC分类号： C07D309/12

CPC分类号： C07D307/30 ,  Y02P20/55

摘要： A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 is a protecting group for a hydroxy group; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1 except for when Z1 is Z2 is with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.

摘要翻译： 提供一种制备式（I）表示的脂肪酸衍生物的方法：其中Z 1是其中R 3是羟基的保护基; 其包括使式（II）化合物：其中Z2与Z 1相同，除了当Z 1为Z 2时，其为与氧化剂在氮杂金刚烷-N-氧基衍生物存在下反应的步骤。