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    Production method of isoxazoline-substituted benzoic acid amide compound
    1.
    发明授权
    Production method of isoxazoline-substituted benzoic acid amide compound 有权
    异恶唑啉取代苯甲酸酰胺化合物的制备方法

    公开(公告)号：US08389738B2

    公开(公告)日：2013-03-05

    申请号：US13002837

    申请日：2009-07-09

    申请人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

    发明人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

    IPC分类号： C07D261/04

    CPC分类号： C07D261/04

    摘要： A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, C1-6 haloalkyl, etc., Y is a halogen atom, C1-6 alkyl, etc., R1 is a C1-6 haloalkyl, etc., R2 and R3 independently of each other are a hydrogen atom, C1-6 alkyl, etc., R4 is C1-6 alkyl, C1-6 haloalkyl, etc., R5 is a hydrogen atom, c1-6 alkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R1, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, —C(O)OH, —C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R2, R3, R4, and R5 are the same as defined above, or a salt thereof; crystal forms and the production method thereof.

    摘要翻译： 其中X是卤素原子，C 1-6卤代烷基等的式（1）的异恶唑啉取代的苯甲酸酰胺化合物的制备方法，Y是卤素原子，C 1-6烷基等，R 1是C 1 -6卤代烷基等，R2和R3彼此独立地是氢原子，C1-6烷基等，R4是C1-6烷基，C1-6卤代烷基等，R5是氢原子，c1- 6烷基等，m为0〜5的整数，n为0〜4的整数，包括：使式（3）的异恶唑啉取代的苯化合物，其中X，Y，R 1，m和n分别为 与上述相同，L是氯原子，溴原子，-C（O）OH，-C（O）J等，J是卤素原子，与式（2）的2-氨基乙酰胺化合物 2）其中R2，R3，R4和R5与上述定义相同，或其盐; 晶体形式及其制备方法。

    PRODUCTION METHOD OF ISOXAZOLINE-SUBSTITUTED BENZOIC ACID AMIDE COMPOUND
    2.
    发明申请
    PRODUCTION METHOD OF ISOXAZOLINE-SUBSTITUTED BENZOIC ACID AMIDE COMPOUND 有权
    ISOXAZOLINE-取代苯甲酸酰胺化合物的生产方法

    公开(公告)号：US20110144349A1

    公开(公告)日：2011-06-16

    申请号：US13002837

    申请日：2009-07-09

    申请人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

    发明人： Hiroyuki Kousaka ,  Shunsuke Fukuya ,  Yuji Moriyama ,  Manabu Yaosaka ,  Takashi Mizukoshi

    IPC分类号： C07D261/04

    CPC分类号： C07D261/04

    摘要： A production method of an isoxazoline-substituted benzoic acid amide compound of Formula (1) where X is a halogen atom, C1-6 haloalkyl, etc., Y is a halogen atom, C1-6 alkyl, etc., R1 is a C1-6 haloalkyl, etc., R2 and R3 independently of each other are a hydrogen atom, C1-6 alkyl, etc., R4 is C1-6 alkyl, C1-6 haloalkyl, etc., R5 is a hydrogen atom, c1-6 alkyl, etc., m is an integer of 0 to 5, n is an integer of 0 to 4, including: reacting an isoxazoline-substituted benzene compound of Formula (3) where X, Y, R1, m, and n are the same as defined above, L is a chlorine atom, a bromine atom, —C(O)OH, —C(O)J, etc., J is a halogen atom, with a 2-aminoacetic acid amide compound of Formula (2) where R2, R3, R4, and R5 are the same as defined above, or a salt thereof; crystal forms and the production method thereof.

    摘要翻译： 其中X是卤素原子，C 1-6卤代烷基等的式（1）的异恶唑啉取代的苯甲酸酰胺化合物的制备方法，Y是卤素原子，C 1-6烷基等，R 1是C 1 -6卤代烷基等，R2和R3彼此独立地是氢原子，C1-6烷基等，R4是C1-6烷基，C1-6卤代烷基等，R5是氢原子，c1- 6烷基等，m为0〜5的整数，n为0〜4的整数，包括：使式（3）的异恶唑啉取代的苯化合物，其中X，Y，R 1，m和n分别为 与上述相同，L是氯原子，溴原子，-C（O）OH，-C（O）J等，J是卤素原子，与式（2）的2-氨基乙酰胺化合物 2）其中R2，R3，R4和R5与上述定义相同，或其盐; 晶体形式及其制备方法。

    Isoxazoline-substituted benzamide compound and pesticide
    3.
    发明授权
    Isoxazoline-substituted benzamide compound and pesticide 有权
    异恶唑啉取代苯甲酰胺化合物和农药

    公开(公告)号：US08492311B2

    公开(公告)日：2013-07-23

    申请号：US13350297

    申请日：2012-01-13

    申请人： Takeshi Mita ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda

    发明人： Takeshi Mita ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda

    IPC分类号： A01N43/80 ,  C07D261/04

    CPC分类号： A61K31/421 ,  A01N43/80 ,  A61K9/0053 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07C43/1742 ,  C07C43/1745 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/04 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07F7/0812

    摘要： A substituted alkenylbenzene compound of formula (4): wherein X1 is a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl or C1-C6haloalkylsulfonyl; X3 is a hydrogen, halogen, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy or C1-C6alkylthio; X4 is a hydrogen, halogen, cyano, C1-C4alkyl, C1-C4alkoxy or C1-C4haloalkoxy; R3 is —C(R3a)(R3b)R3c, where R3a and R3b are a halogen, or R3a and R3b together form a 3- to 6-membered ring together with the carbon bonding them by forming a C2-C5haloalkylene chain, and R3c is a hydrogen, halogen, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio, with a proviso that where X1 is a fluorine, chlorine or trifluoromethyl, and X2 and X3 are hydrogen, where X1 and X2 are fluorine and X3 is a hydrogen, or where X1 and X2 are trifluoromethyl and X3 is a hydrogen, R3c is a hydrogen, chlorine, bromine, iodine, C1-C5alkyl, C1-C5haloalkyl, C1-C4haloalkoxy or C1-C4haloalkylthio.

    摘要翻译： 式（4）的取代烯基苯化合物：其中X 1是卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基，C 1 -C 3卤代烷氧基C 1 -C 3卤代烷氧基 ，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基或C 1 -C 6卤代烷基磺酰基; X 3是氢，卤素，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 1 -C 6烷氧基或C 1 -C 6烷硫基; X 4是氢，卤素，氰基，C 1 -C 4烷基，C 1 -C 4烷氧基或C 1 -C 4卤代烷氧基; R3是-C（R3a）（R3b）R3c，其中R3a和R3b是卤素，或者R3a和R3b与通过形成C 2 -C 5卤代亚烷基链键合的碳一起形成3-至6-元环，并且R3c 是卤素，C 1 -C 5烷基，C 1 -C 5卤代烷基，C 1 -C 4卤代烷氧基或C 1 -C 4卤代烷硫基，条件是其中X 1是氟，氯或三氟甲基，X 2和X 3是氢，其中X 1和X 2是氟， X 3是氢，或者其中X 1和X 2是三氟甲基，X 3是氢，R 3c是氢，氯，溴，碘，C 1 -C 5烷基，C 1 -C 5卤代烷基，C 1 -C 4卤代烷氧基或C 1 -C 4卤代烷硫基。

    Isoxazoline-substituted benzamide compound and pesticide
    8.
    发明授权
    Isoxazoline-substituted benzamide compound and pesticide 有权
    异恶唑啉取代苯甲酰胺化合物和农药

    公开(公告)号：US08138213B2

    公开(公告)日：2012-03-20

    申请号：US13166294

    申请日：2011-06-22

    申请人： Takeshi Mita ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda

    发明人： Takeshi Mita ,  Takamasa Kikuchi ,  Takashi Mizukoshi ,  Manabu Yaosaka ,  Mitsuaki Komoda

    IPC分类号： A61K31/42 ,  C07D261/04

    CPC分类号： A61K31/421 ,  A01N43/80 ,  A61K9/0053 ,  C07C25/02 ,  C07C25/06 ,  C07C25/08 ,  C07C25/13 ,  C07C25/24 ,  C07C43/1742 ,  C07C43/1745 ,  C07C205/11 ,  C07C205/12 ,  C07C211/52 ,  C07C251/48 ,  C07C255/29 ,  C07C255/50 ,  C07C255/60 ,  C07C281/02 ,  C07C323/09 ,  C07D261/04 ,  C07D261/16 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07F7/0812

    摘要： A 3,5-Bis (substituted aryl) substituted isoxazoline compound of formula (2) or a salt thereof: wherein A1 is a carbon atom or nitrogen atom; X1 is selected from the group consisting of a halogen atom, —SF5, C1-C6haloalkyl, hydroxy C1-C6haloalkyl, C1-C6alkoxy C1-C6haloalkyl, C1-C6haloalkoxy C1-C6haloalkyl, C3-C8halocycloalkyl, C1-C6haloalkoxy, C1-C3haloalkoxy C1-C3haloalkoxy, C1-C6haloalkylthio, C1-C6haloalkylsulfinyl and C1-C6haloalkylsulfonyl; X2 is selected from the group consisting of a halogen atom, cyano, nitro, C1-C6alkyl, C1-C6haloalkyl, —OR5, —OSO2R5 and —S(O)rR5; Y is selected from the group consisting of a halogen atom, cyano, nitro, C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy, C1-C6alkylthio, C1-C6haloalkylthio, C1-C6alkylsulfonyl, C1-C6haloalkylsulfonyl, —NHR7 and —N(R7)R6; R is selected from the group consisting of a halogen atom, cyano, nitro, —NH2, halosulfonyloxy, C1-C6alkylsulfonyloxy, C1-C6haloalkylsulfonyloxy, phenylsulfonyloxy, phenylsulfonyloxy substituted with (Z)p1 and —C(O)Ra; m1 is an integer of 0 to 2; n is an integer of 0 or 1; p1 is an integer of 1 to 5; and r is an integer of 0 to 2.

    摘要翻译： 式（2）的3,5-双（取代的芳基）取代的异恶唑啉化合物或其盐：其中A1是碳原子或氮原子; X1选自卤素原子，-SF 5，C 1 -C 6卤代烷基，羟基C 1 -C 6卤代烷基，C 1 -C 6烷氧基C 1 -C 6卤代烷基，C 1 -C 6卤代烷氧基C 1 -C 6卤代烷基，C 3 -C 8卤代环烷基，C 1 -C 6卤代烷氧基，C 1 -C 3卤代烷氧基C1 C 3卤代烷氧基，C 1 -C 6卤代烷硫基，C 1 -C 6卤代烷基亚磺酰基和C 1 -C 6卤代烷基磺酰基; X 2选自卤素原子，氰基，硝基，C 1 -C 6烷基，C 1 -C 6卤代烷基，-OR 5，-OSO 2 R 5和-S（O）r R 5; Y选自卤素原子，氰基，硝基，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4烷氧基，C 1 -C 4卤代烷氧基，C 1 -C 6烷硫基，C 1 -C 6卤代烷硫基，C 1 -C 6烷基磺酰基，C 1 -C 6卤代烷基磺酰基，-NHR 7 和-N（R 7）R 6; R选自卤素原子，氰基，硝基，-NH 2，卤代磺酰氧基，C 1 -C 6烷基磺酰氧基，C 1 -C 6卤代烷基磺酰氧基，苯基磺酰氧基，被（Z）p1和-C（O）Ra取代的苯基磺酰氧基; m1为0〜2的整数; n为0或1的整数; p1为1〜5的整数， r为0〜2的整数。