公开(公告)号：US09182216B2

公开(公告)日：2015-11-10

申请号：US13825280

申请日：2011-09-20

Applicant: Norihiko Nishizawa ,  Hiroyoshi Matsumura ,  Yuusuke Mori ,  Shutaro Ishida ,  Kazuyoshi Itoh ,  Shigeru Sugiyama ,  Hiroaki Adachi ,  Tsuyoshi Inoue ,  Kazufumi Takano ,  Murakami Satoshi

Inventor： Norihiko Nishizawa ,  Hiroyoshi Matsumura ,  Yuusuke Mori ,  Shutaro Ishida ,  Kazuyoshi Itoh ,  Shigeru Sugiyama ,  Hiroaki Adachi ,  Tsuyoshi Inoue ,  Kazufumi Takano ,  Murakami Satoshi

IPC: G01B9/02 ,  G01N21/47 ,  C07K1/30 ,  G01N21/17

CPC classification number: G01B9/02091 ,  C07K1/306 ,  G01N21/4795 ,  G01N2021/1787

Abstract: Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source;a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source;a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 μm band; anda method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.

Abstract translation: 提供了一种用于观察蛋白质晶体的方法，其中蛋白质晶体的生长过程以实时的方式非破坏性和三维地监测，并且以高精度控制晶体的生长，从而能够形成单晶 具有良好的质量，其包括通过使用从超宽带光源发射的光的OCT测量观察蛋白质晶体，所述蛋白质晶体是通过使用凝胶的结晶方法产生的; 一种观察蛋白质晶体的方法，其中超宽带光源是超宽带超连续光源; 观察从超宽带超连续光源发射的光的中心波长为0.8μm波段的蛋白质晶体的方法; 以及观察蛋白质晶体的方法，其中蛋白质晶体的监测是通过原位测量的监测。

公开(公告)号：US20130184445A1

公开(公告)日：2013-07-18

申请号：US13825280

申请日：2011-09-20

Applicant: Norihiko Nishizawa ,  Hiroyoshi Matsumura ,  Yuusuke Mori ,  Shutaro Ishida ,  Kazuyoshi Itoh ,  Shigeru Sugiyama ,  Hiroaki Adachi ,  Tsuyoshi Inoue ,  Kazufumi Takano ,  Murakami Satoshi

Inventor： Norihiko Nishizawa ,  Hiroyoshi Matsumura ,  Yuusuke Mori ,  Shutaro Ishida ,  Kazuyoshi Itoh ,  Shigeru Sugiyama ,  Hiroaki Adachi ,  Tsuyoshi Inoue ,  Kazufumi Takano ,  Murakami Satoshi

IPC: G01B9/02 ,  C07K1/30

CPC classification number: G01B9/02091 ,  C07K1/306 ,  G01N21/4795 ,  G01N2021/1787

Abstract: Provided are a method for observing protein crystal, wherein the growth process of the protein crystals is nondestructively and three-dimensionally monitored on a real-time basis and the growth of the crystals is controlled at a high accuracy to thereby enable the formation of single crystals having good qualities, which comprises observing the protein crystals, said protein crystals having been produced by a crystallization method using a gel, by an OCT measurement using light emitted from an ultrawideband light source;a method for observing protein crystals wherein the ultrawideband light source is an ultrawideband supercontinuum light source; a method for observing protein crystals wherein the center wavelength of the light emitted from the ultrawideband supercontinuum light source is a 0.8 μm band; and a method for observing protein crystals wherein the monitoring of the protein crystals is a monitoring by an in situ measurement.

Abstract translation: 提供了一种用于观察蛋白质晶体的方法，其中蛋白质晶体的生长过程以实时的方式非破坏性和三维地监测，并且以高精度控制晶体的生长，从而能够形成单晶 具有良好的质量，其包括通过使用从超宽带光源发射的光的OCT测量观察蛋白质晶体，所述蛋白质晶体是通过使用凝胶的结晶方法产生的; 一种观察蛋白质晶体的方法，其中超宽带光源是超宽带超连续光源; 观察蛋白质晶体的方法，其中从超宽带超连续光源发射的光的中心波长为0.8μm波段; 以及观察蛋白质晶体的方法，其中蛋白质晶体的监测是通过原位测量的监测。