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公开(公告)号：US20140134234A1
公开(公告)日：2014-05-15
申请号：US14037892
申请日：2013-09-26
申请人： Paul A. Grayburn , Shuyuan Chen
发明人： Paul A. Grayburn , Shuyuan Chen
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1272 , A61K9/1274 , A61K41/0028 , A61K48/0075
摘要： The present invention includes compositions and methods for delivering one or more active agents in vivo by contacting a target organ or tissue with a microbubble encapsulated active agent comprising a neutrally charged lipid microbubble loaded with cationic liposomes comprising one or more active agents and selectively releasing the active agents at the target by exposing the microbubble at the target with ultrasound, wherein the active agents remain protected in the microbubble until selectively release at the target.
摘要翻译： 本发明包括用于通过使靶器官或组织与微泡包封的活性剂接触的组合物和方法，所述微泡包封的活性剂包含负载有包含一种或多种活性剂的阳离子脂质体的中性带电脂质微泡，并选择性释放活性物质 通过用超声波将目标物上的微泡暴露于目标物上，其中活性剂在微泡中保持保护，直到在靶上有选择地释放。
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公开(公告)号：US20080263086A1
公开(公告)日：2008-10-23
申请号：US11788406
申请日：2007-04-19
IPC分类号： G06F17/00
摘要： Embodiments of the present invention improve information exchange, and in particular, the exchange of data objects between different software systems. In one embodiment, the present invention includes a method of exchanging information comprising analyzing the attributes of the objects. Objects may be stored in a repository and retrieved using attributes. In some applications, objects are received and sent to participants without accessing any information in the objects themselves. Different applications include object warehousing operable across different communication mediums that support different names or name spaces, classes, aliases, groups, geospatial information, or tokens, or combinations thereof.
摘要翻译： 本发明的实施例改进了信息交换，特别是在不同的软件系统之间交换数据对象。 在一个实施例中，本发明包括交换信息的方法，包括分析对象的属性。 对象可能存储在存储库中，并使用属性进行检索。 在某些应用中，对象被接收并发送给参与者而不访问对象本身中的任何信息。 不同的应用程序包括可支持不同通信介质的对象仓库，这些介质支持不同的名称或名称空间，类，别名，组，地理空间信息或令牌，或其组合。
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公开(公告)号：US20060206348A1
公开(公告)日：2006-09-14
申请号：US11151516
申请日：2005-06-14
申请人： Shuyuan Chen , Kaj Loo
发明人： Shuyuan Chen , Kaj Loo
IPC分类号： G06Q99/00
CPC分类号： G06Q10/06 , G06Q10/063 , G06Q10/06313 , G06Q10/06316 , G06Q10/0637
摘要： Embodiments of the present invention relate to an automated way for a non-technical person to create or modify software functionality in support of a business process without needing expertise in software. According to the invention, an automated matching tool may apply user input expressed semantically to a database of semantic information associated with syntactic information, to match the user input with a service (e.g., an application program) capable of performing a business process step corresponding to the input.
摘要翻译： 本发明的实施例涉及非技术人员创建或修改支持业务流程的软件功能而不需要软件专长的自动化方式。 根据本发明，自动匹配工具可以将用语义表达的用户输入应用于与语法信息相关联的语义信息的数据库，以将用户输入与能够执行对应于业务处理步骤的业务（例如，应用程序）匹配 输入。
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公开(公告)号：US08775450B2
公开(公告)日：2014-07-08
申请号：US11788406
申请日：2007-04-19
IPC分类号： G06F17/30
摘要： Embodiments of the present invention improve information exchange, and in particular, the exchange of data objects between different software systems. In one embodiment, the present invention includes a method of exchanging information comprising analyzing the attributes of the objects. Objects may be stored in a repository and retrieved using attributes. In some applications, objects are received and sent to participants without accessing any information in the objects themselves. Different applications include object warehousing operable across different communication mediums that support different names or name spaces, classes, aliases, groups, geospatial information, or tokens, or combinations thereof.
摘要翻译： 本发明的实施例改进了信息交换，特别是在不同的软件系统之间交换数据对象。 在一个实施例中，本发明包括交换信息的方法，包括分析对象的属性。 对象可能存储在存储库中，并使用属性进行检索。 在某些应用中，对象被接收并发送给参与者而不访问对象本身中的任何信息。 不同的应用程序包括可支持不同通信介质的对象仓库，这些介质支持不同的名称或名称空间，类，别名，组，地理空间信息或令牌，或其组合。
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5.发明申请In-Vivo Non-Viral Gene Delivery of Human Vascular Endothelial Growth Factor Following Islet Transplantation 审中-公开体外非病毒基因递送人类血管内皮生长因子胰岛移植后公开(公告)号：US20110182979A1
公开(公告)日：2011-07-28
申请号：US13014926
申请日：2011-01-27
CPC分类号： A61K35/39 , A61K9/2077 , A61K38/1866 , A61K48/0075 , C12N15/87 , A61K2300/00
摘要： An ultrasound-mediated gene transfer method named Ultrasound Targeted Microbubble Destruction (UTMD) for the delivery of human vascular endothelial growth factor (hVEGF) gene to transplanted islets and the surrounding tissue is described herein. The delivery of hVEGF promotes islet revascularization and survival. The inventors, first transplanted human islets were transplanted into diabetic nude mice liver followed by the induction of non-viral plasmid vectors encoding hVEGF or Green Fluorescent Protein (GFP) gene in the host liver by UTMD. Transplantation without gene delivery was also performed as a control. Blood glucose, serum human insulin, C-peptide levels and the revascularization in graft islets were evaluated. The findings of the method of the present invention indicated that hVEGF gene delivery to host liver using UTMD promoted islet revascularization after islet transplantation and improved the restoration of euglycemia.
摘要翻译： 本文描述了称为超声靶向微泡破坏（UTMD）的超声介导的基因转移方法，用于将移植的胰岛和周围组织递送人血管内皮生长因子（hVEGF）基因。 hVEGF的输送促进胰岛血运重建和存活。 将本发明人首先将移植的人胰岛移植到糖尿病裸小鼠肝脏中，然后通过UTMD诱导宿主肝脏中编码hVEGF或绿色荧光蛋白（GFP）基因的非病毒质粒载体。 也进行无基因递送移植作为对照。 评估血糖，血清人胰岛素，C肽水平和移植胰岛血运重建。 本发明方法的发现表明，使用UTMD的hVEGF基因递送至宿主肝，促进了胰岛移植后胰岛血运重建，改善了正常血糖的恢复。
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6.发明申请NEUROD1 GENE EXPRESSION IN NON-ENDOCRINE PANCREATIC EPITHELIAL CELLS (NEPECs) 审中-公开非内皮素胰腺上皮细胞中的NEUROD1基因表达（NEPECs）公开(公告)号：US20120009244A1
公开(公告)日：2012-01-12
申请号：US13071458
申请日：2011-03-24
CPC分类号： C12N15/85 , A61K38/1883 , C07K14/4702 , C12N2830/008
摘要： The introduction of the human NeuroD1 gene into human non-endocrine pancreatic epithelial cells (NEPECs) for producing insulin producing cells in vitro is described herein. Cytokeratin19 (CK19) positive NEPECs were transfected with plasmids encoding human NeuroD1 gene under human CK19 promoter. On characterization following the induction it was found that NEPEC+ND strongly expressed NeuroD1 and insulin mRNA. The ratio of NeuroD1 and human insulin positive cells in NEPEC+ND was significantly higher than NEPEC. Human insulin and C-peptide levels in culture media in NEPEC+ND were significantly higher than NEPEC. The findings demonstrate that human NeuroD1 under control of the CK19 promoter induces the differentiation of CK19 positive NEPECs into insulin producing cells.
摘要翻译： 本文描述了将人NeuroD1基因导入用于在体外产生胰岛素产生细胞的人非内分泌胰腺上皮细胞（NEPEC）中。 在人CK19启动子下用编码人NeuroD1基因的质粒转染细胞角蛋白19（CK19）阳性NEPEC。 在诱导后的表征中，发现NEPEC + ND强烈表达NeuroD1和胰岛素mRNA。 NEPEC + ND中NeuroD1和人胰岛素阳性细胞的比例显着高于NEPEC。 NEPEC + ND培养基中人胰岛素和C肽水平明显高于NEPEC。 研究结果表明，CK19启动子控制下的人NeuroD1诱导CK19阳性NEPEC分化为胰岛素生成细胞。
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公开(公告)号：US08015051B2
公开(公告)日：2011-09-06
申请号：US11151516
申请日：2005-06-14
申请人： Shuyuan Chen , Kaj Van De Loo
发明人： Shuyuan Chen , Kaj Van De Loo
IPC分类号： G06Q10/00
CPC分类号： G06Q10/06 , G06Q10/063 , G06Q10/06313 , G06Q10/06316 , G06Q10/0637
摘要： Embodiments of the present invention relate to an automated way for a non-technical person to create or modify software functionality in support of a business process without needing expertise in software. According to the invention, an automated matching tool may apply user input expressed semantically to a database of semantic information associated with syntactic information, to match the user input with a service (e.g., an application program) capable of performing a business process step corresponding to the input.
摘要翻译： 本发明的实施例涉及非技术人员创建或修改支持业务流程的软件功能而不需要软件专长的自动化方式。 根据本发明，自动匹配工具可以将用语义表达的用户输入应用于与语法信息相关联的语义信息的数据库，以将用户输入与能够执行与...相对应的业务处理步骤的服务（例如，应用程序）相匹配 输入。
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8.发明授权Context based event handling and execution with prioritization and interrupt management 有权基于上下文的事件处理和执行，具有优先级和中断管理公开(公告)号：US07865887B2
公开(公告)日：2011-01-04
申请号：US11606701
申请日：2006-11-30
IPC分类号： G06F9/45
CPC分类号： G06F9/542 , G06F2209/544
摘要： Embodiments of the present invention provide improved event handling between systems. In one embodiment, the present invention includes software event handling method comprising receiving a first event from a first source system in a plurality of source systems, the first event including event information, accessing context information corresponding to the first event, generating a second event based on at least a portion of the event information and context information using one or more rules, assigning a priority to the second event, and sending the second event to a first target system in a plurality of target systems.
摘要翻译： 本发明的实施例提供了系统之间改进的事件处理。 在一个实施例中，本发明包括软件事件处理方法，包括从多个源系统中的第一源系统接收第一事件，所述第一事件包括事件信息，访问对应于第一事件的上下文信息，生成基于第二事件的第二事件 在使用一个或多个规则的事件信息和上下文信息的至少一部分上分配给第二事件的优先级，以及将第二事件发送到多个目标系统中的第一目标系统。
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公开(公告)号：US07480936B2
公开(公告)日：2009-01-20
申请号：US10248381
申请日：2003-01-15
申请人： Bruce C. Lyon , Xin Xu , Shuyuan Chen
发明人： Bruce C. Lyon , Xin Xu , Shuyuan Chen
CPC分类号： H04L63/0272 , H04L63/029
摘要： Communication systems and methods transfer information between a client device and a vendor device through a firewall between the client device and the vendor device by using a communications protocol that will normally allows pass through the firewall and/or by e embedding the information in a file format that will normally pass through the firewall. The information can be transmitted using the hypertext transfer protocol, and/or is embedded in an HTTP document or in an e-mail message. If the client device is on a secure side of the firewall and the vendor device needs to initiate communication with the client device, the vendor device can send an e-mail message to the client device asking the client device to initiate the communication session. Because the client device has initiated the communication, the firewall should allow the response to the client device's request to pass through from the vendor device to the client device.
摘要翻译： 通信系统和方法通过使用通常允许通过防火墙的通信协议和/或通过以文件格式嵌入信息来通过客户端设备和供应商设备之间的防火墙在客户端设备和供应商设备之间传送信息 这通常将通过防火墙。 该信息可以使用超文本传输协议传输，和/或嵌入在HTTP文档或电子邮件消息中。 如果客户端设备位于防火墙的安全侧，并且供应商设备需要发起与客户端设备的通信，则供应商设备可以向客户端设备发送电子邮件消息，要求客户端设备启动通信会话。 因为客户端设备已经启动了通信，防火墙应该允许对客户端设备的请求的响应从供应商设备传递到客户端设备。
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10.发明申请Regeneration of Pancreatic Islets and Reversal of Diabetes by Islet Transcription Factor Genes Delivered In Vivo 审中-公开胰岛的再生和体内交付的胰岛转录因子基因逆转糖尿病公开(公告)号：US20140294924A1
公开(公告)日：2014-10-02
申请号：US14191402
申请日：2014-02-26
申请人： Paul A. Grayburn , Shuyuan Chen , Jiahuan Ding
发明人： Paul A. Grayburn , Shuyuan Chen , Jiahuan Ding
IPC分类号： A61K9/127 , A61K31/713
CPC分类号： A61K9/1271 , A61K31/713 , A61K41/0028 , A61K48/005 , A61K48/0058 , A61K48/0083
摘要： The present invention includes compositions and methods for regenerating glucose-responsive cells by ultrasound-targeted microbubble destruction in the pancreas, wherein the composition comprises a pre-assembled liposome-nucleic acid complex in contact with within and about a microbubble, wherein the pre-assembled liposome-nucleic acid complex comprises a NeuroD gene under the control of the promoter, wherein disruption of the microbubble in the pancreas at a target site delivers the nucleic acid into pancreas cells at the location of the ultrasound disruption, wherein cells that incorporate the nucleic acid express insulin in response to high blood glucose levels.
摘要翻译： 本发明包括通过胰腺中的超声靶向微泡破坏再生葡萄糖反应性细胞的组合物和方法，其中所述组合物包含与微泡内和周围接触的预组装的脂质体 - 核酸复合物，其中预组装 脂质体 - 核酸复合物包含在启动子控制下的NeuroD基因，其中在靶位点胰腺中的微泡破裂在超声破坏的位置将核酸递送到胰腺细胞，其中掺入核酸的细胞 响应于高血糖水平表达胰岛素。
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