公开(公告)号：US20110280925A1

公开(公告)日：2011-11-17

申请号：US13060325

申请日：2010-04-22

申请人： Hock Seng Tan ,  Siew Lian Chung

发明人： Hock Seng Tan ,  Siew Lian Chung

IPC分类号： A61K9/70 ,  A61P1/08 ,  A61K31/445 ,  A61K31/439 ,  A61K31/465 ,  A61K31/485

CPC分类号： A61M35/00 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/7007 ,  A61K47/32 ,  A61K47/34

摘要： Provided is a dual-release, dual-adhesiveness flexible thin film dosage form comprising: a quick-release subfilm comprising an admixture of polymer, which comprises predominantly highly water-soluble polymer(s), and a bioactive agent, the polymers and other components of the quick-release subfilm adapted to provide 20 minute or less erodibility for the quick-release subfilm; and laminated against the quick-release subfilm, a sustained-release subfilm comprising an admixture of polymer, which comprises predominantly hydrophilic, bioadhesive polymer(s), and a second bioactive agent, which can be the same as the first, the polymers and other components of the sustained-release subfilm adapted to provide erodibility of 1 hours or more and 20 hours or less for the sustained-release subfilm, the dosage form having a thickness of 30 mil or less, and being more adhesive on the sustained-release side.

摘要翻译： 提供了一种双重释放双重粘合性柔性薄膜剂型，其包含：快速释放子膜，其包含聚合物的混合物，所述聚合物主要包含高度水溶性聚合物和生物活性剂，所述聚合物和其它组分 的快速释放子膜适于为快速释放子膜提供20分钟或更短的可蚀性; 并且与快速释放子膜层压，包含主要包含亲水性生物粘附聚合物的聚合物混合物和第二生物活性剂的缓释亚膜，其可以与第一种聚合物和其它物质相同 持续释放亚膜的组分适于为持续释放亚膜提供1小时或更长和20小时以下的可蚀刻性，所述剂型具有30密耳或更小的厚度，并且在持续释放侧上更粘合 。

公开(公告)号：US09017718B2

公开(公告)日：2015-04-28

申请号：US13060325

申请日：2010-04-22

申请人： Hock Seng Tan ,  Siew Lian Chung

发明人： Hock Seng Tan ,  Siew Lian Chung

IPC分类号： A61M35/00 ,  A61K47/32 ,  A61K47/34 ,  A61K9/00 ,  A61K9/70

CPC分类号： A61M35/00 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/7007 ,  A61K47/32 ,  A61K47/34

摘要： Provided is a dual-release, dual-adhesiveness flexible thin film dosage form comprising: a quick-release subfilm comprising an admixture of polymer, which comprises predominantly highly water-soluble polymer(s), and a bioactive agent, the polymers and other components of the quick-release subfilm adapted to provide 20 minutes or less erodibility for the quick-release subfilm; and laminated against the quick-release subfilm, a sustained-release subfilm comprising an admixture of polymer, which comprises predominantly hydrophilic, bioadhesive polymer(s), and a second bioactive agent, which can be the same as the first, the polymers and other components of the sustained-release subfilm adapted to provide erodibility of 1 hour or more and 20 hours or less for the sustained-release subfilm, the dosage form having a thickness of 30 mil or less, and being more adhesive on the sustained-release side.

摘要翻译： 提供了一种双重释放双重粘合性柔性薄膜剂型，其包含：快速释放子膜，其包含聚合物的混合物，所述聚合物主要包含高度水溶性聚合物和生物活性剂，所述聚合物和其它组分 的快速释放子膜适于为快速释放子膜提供20分钟或更短的可蚀刻性; 并且与快速释放子膜层压，包含主要包含亲水性生物粘附聚合物的聚合物混合物和第二生物活性剂的缓释亚膜，其可以与第一种聚合物和其它物质相同 持续释放亚膜的组分适于为持续释放亚膜提供1小时或更长和20小时以下的可蚀刻性，剂型具有30密耳或更小的厚度，并且在持续释放侧上更粘合 。