公开(公告)号：US20120230978A1

公开(公告)日：2012-09-13

申请号：US13413907

申请日：2012-03-07

申请人： Gregor Eichele ,  Henrik Oster ,  Silke Kiessling

发明人： Gregor Eichele ,  Henrik Oster ,  Silke Kiessling

IPC分类号： A61K31/444 ,  C07K16/00 ,  A61P25/00 ,  C07H21/02 ,  A61K31/713 ,  A61K31/7105 ,  C07D401/06 ,  A61K39/395

CPC分类号： A61K31/444 ,  A61K31/7105 ,  A61K31/713

摘要： The present invention relates to a modulator of glucocorticoid biosynthesis, degradation and/or receptor activation for use in preventing or treating symptoms and/or diseases associated with jet lag. The compositions of the invention may be used as a lead compound for developing a drug for preventing or treating symptoms and/or diseases associated with jet lag. The invention relates to the discovery that administration of the modulator(s) to a subject results in a directional change of the time point of maximum amounts of glucocorticoids in the subject as compared to the time point of maximum amounts of glucocorticoids in a subject not treated with the modulator(s).

摘要翻译： 本发明涉及用于预防或治疗与时差相关的症状和/或疾病的糖皮质激素生物合成，降解和/或受体活化的调节剂。 本发明的组合物可用作开发用于预防或治疗与时差相关的症状和/或疾病的药物的铅化合物。 本发明涉及以下发现：相对于未经治疗的受试者中最大量的糖皮质激素的时间点，向受试者施用调节剂导致受试者中最大量糖皮质激素的时间点的定向改变 与调制器。

公开(公告)号：US08946263B2

公开(公告)日：2015-02-03

申请号：US13413907

申请日：2012-03-07

申请人： Gregor Eichele ,  Henrik Oster ,  Silke Kiessling

发明人： Gregor Eichele ,  Henrik Oster ,  Silke Kiessling

IPC分类号： A61K31/44 ,  A61K31/444 ,  A61K31/7105 ,  A61K31/713

CPC分类号： A61K31/444 ,  A61K31/7105 ,  A61K31/713

摘要： The present invention relates to a modulator of glucocorticoid biosynthesis, degradation and/or receptor activation for use in preventing or treating symptoms and/or diseases associated with jet lag. The compositions of the invention may be used as a lead compound for developing a drug for preventing or treating symptoms and/or diseases associated with jet lag. The invention relates to the discovery that administration of the modulator(s) to a subject results in a directional change of the time point of maximum amounts of glucocorticoids in the subject as compared to the time point of maximum amounts of glucocorticoids in a subject not treated with the modulator(s).

摘要翻译： 本发明涉及用于预防或治疗与时差相关的症状和/或疾病的糖皮质激素生物合成，降解和/或受体活化的调节剂。 本发明的组合物可用作开发用于预防或治疗与时差相关的症状和/或疾病的药物的铅化合物。 本发明涉及以下发现：相对于未经治疗的受试者中最大量的糖皮质激素的时间点，向受试者施用调节剂导致受试者中最大量糖皮质激素的时间点的定向改变 与调制器。