公开(公告)号：US20100296363A1

公开(公告)日：2010-11-25

申请号：US12739256

申请日：2008-04-29

申请人： Simone Grandi ,  Silvia Grasselli

发明人： Simone Grandi ,  Silvia Grasselli

IPC分类号： B01F5/08

CPC分类号： B01F5/0681 ,  B01F3/0807 ,  B01F5/0663 ,  B01F5/068 ,  B01F2003/125 ,  B01F2215/0006

摘要： A homogenizer valve (1) comprising a ring-shaped first chamber (5) with an inlet (8) for receiving fluid under high pressure, a second ring-shaped chamber (7) with an outlet (9) for fluid under low pressure, a passage head (10) and, between the first and the second chamber, an impact head (11) which is axially mobile with respect to the passage head (10) and acts together with it to define a gap between the impact head (11) and the passage head (10) forming a passage (14) for the fluid passing from the first chamber to the second chamber, and a pusher (15) acting on the impact head (11) to push it in an axial direction towards the passage head (10) thus partially counteracting the pressure exerted by the fluid contained in the first chamber (5) on the annular surface (13) of the impact head (11), this passage (14) comprising at least a first portion (20) and a second portion (21) positioned in sequence between the first chamber and the second chamber, and where the first portion faces in a radial direction and the second portion faces in a direction with an axial component.

摘要翻译： 一种均化器阀（1），包括具有用于在高压下接收流体的入口（8）的环形第一室（5），具有用于在低压下流体的出口（9）的第二环形室（7） 通道头部（10），并且在第一和第二腔室之间具有相对于通道头部（10）可轴向移动的冲击头部（11），并与其一起作用以限定冲击头部（11）之间的间隙 ）和所述通道头（10）形成用于流体从第一室传递到第二室的通道（14），以及作用在冲击头（11）上的推动器（15），以将其沿轴向推向 通道头部（10）因此部分地抵消由包含在第一腔室（5）中的流体施加在冲击头部（11）的环形表面（13）上的压力，该通道（14）包括至少第一部分 ）和第二部分（21），其顺序地定位在第一室和第二室之间，并且第一部分面对 并且第二部分面向具有轴向分量的方向。

公开(公告)号：US08585277B2

公开(公告)日：2013-11-19

申请号：US12739256

申请日：2008-04-29

申请人： Simone Grandi ,  Silvia Grasselli

发明人： Simone Grandi ,  Silvia Grasselli

IPC分类号： B01F5/06

CPC分类号： B01F5/0681 ,  B01F3/0807 ,  B01F5/0663 ,  B01F5/068 ,  B01F2003/125 ,  B01F2215/0006

摘要： A homogenizer valve (1) comprising a ring-shaped first chamber (5) with an inlet (8) for receiving fluid under high pressure, a second ring-shaped chamber (7) with an outlet (9) for fluid under low pressure, a passage head (10) and, between the first and the second chamber, an impact head (11) which is axially mobile with respect to the passage head (10) and acts together with it to define a gap between the impact head (11) and the passage head (10) forming a passage (14) for the fluid passing from the first chamber to the second chamber, and a pusher (15) acting on the impact head (11) to push it in an axial direction towards the passage head (10) thus partially counteracting the pressure exerted by the fluid contained in the first chamber (5) on the annular surface (13) of the impact head (11), this passage (14) comprising at least a first portion (20) and a second portion (21) positioned in sequence between the first chamber and the second chamber, and where the first portion faces in a radial direction and the second portion faces in a direction with an axial component.

摘要翻译： 一种均化器阀（1），包括具有用于在高压下接收流体的入口（8）的环形第一室（5），具有用于在低压下流体的出口（9）的第二环形室（7） 通道头部（10），并且在第一和第二腔室之间具有相对于通道头部（10）可轴向移动的冲击头部（11），并与其一起作用以限定冲击头部（11）之间的间隙 ）和所述通道头（10）形成用于流体从第一室传递到第二室的通道（14），以及作用在冲击头（11）上的推动器（15），以将其沿轴向推向 通道头部（10）因此部分地抵消由包含在第一腔室（5）中的流体施加在冲击头部（11）的环形表面（13）上的压力，该通道（14）包括至少第一部分 ）和第二部分（21），其顺序地定位在第一室和第二室之间，并且第一部分面对 并且第二部分面向具有轴向分量的方向。

公开(公告)号：US07240862B2

公开(公告)日：2007-07-10

申请号：US10937338

申请日：2004-09-10

申请人： Silvia Grasselli ,  Marco Gandini ,  Simone Grandi

发明人： Silvia Grasselli ,  Marco Gandini ,  Simone Grandi

IPC分类号： B01F5/06

CPC分类号： F04B53/007 ,  B01F5/0663 ,  B01F5/068

摘要： Method for disrupting S. Cerevisiae yeast cells in an aqueous solution, by means of a continuous process under high pressure (up to 4000 bar), using a homogenizer.The suspension to be processed passes through a homogenizing valve with a “sharp edge” or “knife edge” passage head in order to achieve a 100% cell disruption rate with a single passage, at a dynamic pressure equal to or above 2000 bar.The “sharp edge” or “knife edge” profile of the passage head (4) is characterized by an inside diameter (9) of 10.9-14 mm and an outside diameter (10) of 11.9 mm-15 mm, and operates at a flow rate of 100-500 liters/hour and a dynamic pressure of more than 2000 bar.

摘要翻译： 使用均化器在高压（高达4000巴）下通过连续方法在水溶液中破坏酿酒酵母细胞的方法。 待处理的悬浮液通过具有“锋利边缘”或“刀刃”通道头的均质阀，以便在等于或高于2000巴的动态压力下，通过单个通道实现100％的细胞破碎速率。 通道头（4）的“锋利边缘”或“刀刃”轮廓的特征在于内径（9）为10.9-14mm，外径（10）为11.9mm-15mm，并在 流量100-500升/小时，动态压力大于2000巴。

公开(公告)号：US5887971A

公开(公告)日：1999-03-30

申请号：US865004

申请日：1997-05-29

申请人： Marco Gandini ,  Adelmo Volpi ,  Silvia Grasselli

发明人： Marco Gandini ,  Adelmo Volpi ,  Silvia Grasselli

IPC分类号： B01F5/06 ,  B01F5/08

CPC分类号： B01F5/068 ,  B01F5/0663

摘要： In a homogenization unit, a homogenizing valve comprises an impact head which, with a lower valve body, forms an annular high-pressure chamber (64) supplied by a high pressure channel (24). An annular surface of the impact head cooperates with an opposite face of a passage head (22) accommodated in the lower valve body to define a radial passage gap, with an impact ring facing it; the gap leads into a low-pressure annular chamber (54) from which a low pressure channel (34) leads off. The impact head comprises two spaced out guide areas to guide the head in the valve body.

摘要翻译： 在均质单元中，均质阀包括冲击头，冲击头与下阀体形成由高压通道（24）供应的环形高压室（64）。 冲击头的环形表面与容纳在下阀体中的通道头（22）的相对面配合，以限定径向通道间隙，其中冲击环面向它; 间隙通向低压通道（34）引出的低压环形室（54）。 冲击头包括两个间隔开的引导区域，以将头部引导到阀体中。

公开(公告)号：US20050197409A1

公开(公告)日：2005-09-08

申请号：US10937338

申请日：2004-09-10

申请人： Silvia Grasselli ,  Marco Gandini ,  Simone Grandi

发明人： Silvia Grasselli ,  Marco Gandini ,  Simone Grandi

IPC分类号： A47J19/06

CPC分类号： F04B53/007 ,  B01F5/0663 ,  B01F5/068

摘要： Method for disrupting S. Cerevisiae yeast cells in an aqueous solution, by means of a continuous process under high pressure (up to 4000 bar), using a homogenizer. The suspension to be processed passes through a homogenizing valve with a “sharp edge” or “knife edge” passage head in order to achieve a 100% cell disruption rate with a single passage, at a dynamic pressure equal to or above 2000 bar. The “sharp edge” or “knife edge” profile of the passage head (4) is characterized by an inside diameter (9) of 10.9-14 mm and an outside diameter (10) of 11.9 mm-15 mm, and operates at a flow rate of 100-500 liters/hour and a dynamic pressure of more than 2000 bar.

摘要翻译： 使用均化器在高压（高达4000巴）下通过连续方法在水溶液中破坏酿酒酵母细胞的方法。 待处理的悬浮液通过具有“锋利边缘”或“刀刃”通道头的均质阀，以便在等于或高于2000巴的动态压力下，通过单个通道实现100％的细胞破碎速率。 通道头（4）的“锋利边缘”或“刀刃”轮廓的特征在于内径（9）为10.9-14mm，外径（10）为11.9mm-15mm，并在 流量100-500升/小时，动态压力大于2000巴。