公开(公告)号：US20240353405A1

公开(公告)日：2024-10-24

申请号：US18682794

申请日：2022-08-08

申请人： Agency for Science, Technology and Research ,  Singapore Heavy Engineering Pte Ltd

发明人： Laura SUTARLIE ,  Xiaodi SU ,  Alan Jenting SHE ,  Khin Moh Moh AUNG

IPC分类号： G01N33/569 ,  G01N33/543 ,  G01N35/10

CPC分类号： G01N33/56911 ,  G01N33/54386 ,  G01N35/1002 ,  G01N35/1067 ,  G01N35/1095

摘要： The disclosure concerns bacterial cell counting devices, systems and methods thereof. The bacterial cell counting device comprises at least one cartridge for containing reagents; an inlet for introducing a sample containing bacterial cells into the device; an optofluidic chip separately in fluid communication with the cartridge and the inlet; a filter strip passing through the optofluidic chip and in fluid communication with the cartridge and the inlet, the filter strip for trapping or retaining bacterial cells on its surface such that the bacterial cells can interact with the reagents as they flow through the filter strip; and a controller for controlling a sequential flow of reagents and sample to the filter strip via the optofluidic chip. The optofluidic chip is capable of detecting a colorimetric and/or fluorescence output emitted from the bacterial cells modified by the reagents in order for the bacterial cells to be quantified relative to a control.