公开(公告)号：US20110301716A1

公开(公告)日：2011-12-08

申请号：US12668706

申请日：2008-07-10

申请人： Sirinrath Sirivisoot ,  Chang Yao ,  Xingcheng Xiao ,  Brian Sheldon ,  Thomas Webster

发明人： Sirinrath Sirivisoot ,  Chang Yao ,  Xingcheng Xiao ,  Brian Sheldon ,  Thomas Webster

IPC分类号： A61F2/28 ,  B05D7/14 ,  C23C28/00 ,  A61N1/00 ,  B05D5/00 ,  C25D11/02 ,  B82Y40/00

CPC分类号： A61L27/50 ,  A61L2400/18

摘要： A method to enhance osteoblast functionality of a medical implant. The method may include obtaining the medical implant and treating a surface of the medical implant to modify the surface characteristics causing increase functionality of adjacent positioned osteoblasts. A method of increasing cellular activity of a medical implant is also disclosed. A medical device having enhanced cytocompatibility capabilities includes a metallic substrate with an outer surface. Attached to the outer surface is a composition of nanosized structures. A biosensor for use with a medical device, includes an electrode that is attached to an outer surface of the medical device. The biosensor measures electrochemical changes adjacent to the medical implant. Further, a method of manufacturing a medical implant with a biosensor for use in vivo and a method of integrating a biosensor with a medical implant for use in monitoring conductivity and electrochemical changes adjacent to the medical implant are disclosed.

摘要翻译： 一种增强医学植入物成骨细胞功能的方法。 该方法可以包括获得医疗植入物并处理医用植入物的表面以改变表面特征，导致相邻定位的成骨细胞增加功能。 还公开了增加医疗植入物的细胞活性的方法。 具有增强的细胞相容性能力的医疗装置包括具有外表面的金属基底。 附着于外表面的是纳米尺寸结构的组合物。 用于医疗装置的生物传感器包括附着在医疗装置的外表面上的电极。 生物传感器测量与医用植入物相邻的电化学变化。 此外，公开了一种制造具有用于体内的生物传感器的医用植入物的方法以及将生物传感器与医用植入物整合的方法，用于监测与医疗植入物相邻的导电性和电化学变化。