公开(公告)号：US20240317727A1

公开(公告)日：2024-09-26

申请号：US18662751

申请日：2024-05-13

Applicant: Duke University ,  Sisu Pharma, Inc.

Inventor： Dennis J. Thiele ,  Sean O'Brien

IPC: C07D413/12 ,  C07C275/40 ,  C07C311/08 ,  C07C317/14 ,  C07D257/04 ,  C07D265/30 ,  C07D285/14 ,  C07D307/81 ,  C07D333/66 ,  C07D333/76 ,  C07D335/06 ,  C07D409/12

CPC classification number: C07D413/12 ,  C07C275/40 ,  C07C311/08 ,  C07C317/14 ,  C07D257/04 ,  C07D265/30 ,  C07D285/14 ,  C07D307/81 ,  C07D333/66 ,  C07D333/76 ,  C07D335/06 ,  C07D409/12 ,  C07C2601/16

Abstract: This disclosure relates to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating diseases related to Heat Shock Transcription Factor 1 (HSF1) activity and/or function. More particularly, this disclosure relates to methods of inhibiting HSF1 activity with these compounds and pharmaceutical compositions thereof, and methods of treating diseases associated with HSF1 activity and/or function, such as cancer.