公开(公告)号：US20240253023A1

公开(公告)日：2024-08-01

申请号：US11867898

申请日：2007-10-05

申请人： Christophe Michot ,  Michel Armand ,  Michel Gauthier ,  Yves Choquette

发明人： Christophe Michot ,  Michel Armand ,  Michel Gauthier ,  Yves Choquette

IPC分类号： B01J31/02 ,  B01J31/04 ,  B01J31/06 ,  B01J31/12 ,  B01J31/18 ,  B01J31/22 ,  C07B37/02 ,  C07B37/12 ,  C07C45/46 ,  C07C45/69 ,  C07C67/00 ,  C07C255/10 ,  C07C255/17 ,  C07C255/27 ,  C07C255/46 ,  C07C255/65 ,  C07C257/14 ,  C07C311/03 ,  C07C311/04 ,  C07C311/09 ,  C07C311/48 ,  C07C317/04 ,  C07C317/08 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/34 ,  C07C317/44 ,  C07D207/452 ,  C07D213/76 ,  C07D219/10 ,  C07D231/18 ,  C07D233/90 ,  C07D239/60 ,  C07D241/42 ,  C07D249/04 ,  C07D249/10 ,  C07D249/12 ,  C07D251/70 ,  C07D277/64 ,  C07D277/82 ,  C07D285/125 ,  C07D285/135 ,  C07D285/15 ,  C07D285/16 ,  C07D303/34 ,  C07D307/54 ,  C07D307/64 ,  C07D311/52 ,  C07D311/58 ,  C07D311/82 ,  C07D319/06 ,  C07D333/16 ,  C07D333/24 ,  C07D405/06 ,  C07D409/12 ,  C07D417/10 ,  C07D417/14 ,  C07F17/02 ,  C08F4/04 ,  C08G65/334 ,  C09B69/00 ,  C09B69/02 ,  C09B69/10 ,  H01B1/12 ,  H01G9/022 ,  H01G11/02 ,  H01G11/62 ,  H01M4/00 ,  H01M4/38 ,  H01M4/58 ,  H01M4/62 ,  H01M6/00 ,  H01M6/16 ,  H01M6/18 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0567 ,  H01M10/0568 ,  G02F1/1516 ,  G02F1/1523 ,  H01M4/02 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/40 ,  H01M4/48 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/60 ,  H01M4/66 ,  H01M6/04

CPC分类号： B01J31/0224 ,  B01J31/0215 ,  B01J31/0222 ,  B01J31/0225 ,  B01J31/0227 ,  B01J31/0235 ,  B01J31/0239 ,  B01J31/0247 ,  B01J31/0251 ,  B01J31/0252 ,  B01J31/0267 ,  B01J31/0271 ,  B01J31/0281 ,  B01J31/0288 ,  B01J31/0289 ,  B01J31/04 ,  B01J31/06 ,  B01J31/068 ,  B01J31/124 ,  B01J31/1815 ,  B01J31/2208 ,  C07B37/02 ,  C07B37/12 ,  C07C45/46 ,  C07C45/69 ,  C07C67/00 ,  C07C255/10 ,  C07C255/17 ,  C07C255/27 ,  C07C255/46 ,  C07C255/65 ,  C07C257/14 ,  C07C311/03 ,  C07C311/04 ,  C07C311/09 ,  C07C311/48 ,  C07C317/04 ,  C07C317/08 ,  C07C317/14 ,  C07C317/22 ,  C07C317/24 ,  C07C317/34 ,  C07C317/44 ,  C07D207/452 ,  C07D213/76 ,  C07D219/10 ,  C07D231/18 ,  C07D233/90 ,  C07D239/60 ,  C07D241/42 ,  C07D249/04 ,  C07D249/10 ,  C07D249/12 ,  C07D251/70 ,  C07D277/64 ,  C07D277/82 ,  C07D285/125 ,  C07D285/135 ,  C07D285/15 ,  C07D285/16 ,  C07D303/34 ,  C07D307/54 ,  C07D307/64 ,  C07D311/52 ,  C07D311/58 ,  C07D311/82 ,  C07D319/06 ,  C07D333/16 ,  C07D333/24 ,  C07D405/06 ,  C07D409/12 ,  C07D417/10 ,  C07D417/14 ,  C07F17/02 ,  C08F4/04 ,  C08G65/3344 ,  C09B69/00 ,  C09B69/02 ,  C09B69/10 ,  H01B1/122 ,  H01B1/128 ,  H01G9/022 ,  H01G11/02 ,  H01G11/62 ,  H01M4/00 ,  H01M4/382 ,  H01M4/5815 ,  H01M4/625 ,  H01M6/00 ,  H01M6/166 ,  H01M6/181 ,  H01M6/183 ,  H01M10/052 ,  H01M10/0525 ,  H01M10/0565 ,  H01M10/0567 ,  H01M10/0568 ,  B01J2231/122 ,  B01J2231/14 ,  B01J2231/326 ,  B01J2231/341 ,  B01J2231/348 ,  B01J2231/4205 ,  B01J2231/543 ,  B01J2531/35 ,  B01J2531/824 ,  C07C2601/10 ,  C07C2602/42 ,  G02F2001/1518 ,  G02F1/1525 ,  H01M4/02 ,  H01M4/131 ,  H01M4/133 ,  H01M4/134 ,  H01M4/405 ,  H01M4/48 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/5825 ,  H01M4/60 ,  H01M4/661 ,  H01M6/04 ,  H01M6/164 ,  H01M6/168 ,  Y02E60/13 ,  Y10S430/127 ,  Y10T29/49108 ,  Y10T428/2918

摘要： The invention concerns ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention is comprised of an amide or one of its salts, including an anionic portion combined with at least one cationic portion M+m in sufficient numbers to ensure overall electronic neutrality; the compound is further comprised of M as a hydroxonium, a nitrosonium NO+, an ammonium —NH4+, a metallic cation with the valence m, an organic cation with the valence m, or an organometallic cation with the valence m. The anionic portion matches the formula RF—SOx—N−Z, where RF is a perflourinated group, x is 1 or 3, and Z is an electroattractive substituent. The compounds can be used notably for ionic conducting materials, electronic conducting materials, colorants and the catalysis of various chemical reactions.

公开(公告)号：US20240239735A1

公开(公告)日：2024-07-18

申请号：US18559891

申请日：2022-05-13

申请人： WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD.

发明人： Liang WANG ,  Jun LOU ,  Yi YUAN ,  Xiaodan GUO ,  Yongkai CHEN ,  Yihan ZHANG ,  Huayun HONG ,  Wei PENG ,  Chaodong WANG

IPC分类号： C07C55/07 ,  A61K31/10 ,  A61K31/194 ,  A61K31/4155 ,  A61K45/06 ,  C07C51/43 ,  C07C57/145 ,  C07C59/255 ,  C07C315/06 ,  C07C317/14 ,  C07D403/04

CPC分类号： C07C55/07 ,  A61K31/10 ,  A61K31/194 ,  A61K31/4155 ,  A61K45/06 ,  C07C51/43 ,  C07C57/145 ,  C07C59/255 ,  C07C315/06 ,  C07C317/14 ,  C07D403/04 ,  C07B2200/13

摘要： An acid addition salt of a ROCK inhibitor, and a crystal form, a composition and the pharmaceutical use thereof are provided. The acid addition salt is an acid addition salt of compound A and any one of the following acids: hydrochloric acid, p-toluenesulfonic acid, benzenesulfonic acid, maleic acid, tartaric acid, oxalic acid, fumaric acid, sulfuric acid, methanesulfonic acid, phosphoric acid, succinic acid or citric acid (A). The acid addition salt of compound A and the crystal form thereof have the characteristics of high solubility, good stability, high purity, few impurities and high bioequivalence, and are beneficial for the storage, quality control and druggability of drugs.

公开(公告)号：US11912654B2

公开(公告)日：2024-02-27

申请号：US17733687

申请日：2022-04-29

申请人： SYNERGIA LIFE SCIENCES PVT. LTD.

发明人： Dilip Mehta ,  Mayank Shashtri ,  BNS Raju ,  Ashwin Shah ,  Parin Vora ,  Umakant Mahale

IPC分类号： C07C46/06 ,  C07C317/14

CPC分类号： C07C46/06 ,  C07C317/14

摘要： The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

公开(公告)号：US11820734B2

公开(公告)日：2023-11-21

申请号：US17506096

申请日：2021-10-20

申请人： ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC)

发明人： Huib Ovaa ,  Maria Wilhelmina Elisabeth Mons ,  Stan Van Boeckel

IPC分类号： C07C317/14 ,  A61P19/10 ,  C07C237/22 ,  C07C237/06 ,  C07C275/40 ,  C07C237/28

CPC分类号： C07C317/14 ,  A61P19/10 ,  C07C237/06 ,  C07C237/22 ,  C07C237/28 ,  C07C275/40

摘要： This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Cathepsin K (CatK), and to a method of inhibiting cathepsin activity, comprising administering a compound or formulation comprising a compound according to the invention.

公开(公告)号：US20190202758A1

公开(公告)日：2019-07-04

申请号：US16098296

申请日：2017-05-02

申请人： DOW GLOBAL TECHNOLOGIES LLC ,  REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Melanie S. SANFORD ,  Douglas BLAND ,  Patrick S. HANLEY ,  Megan A. CISMESIA ,  Sydonie D. SCHIMLER

IPC分类号： C07C17/02 ,  C07C317/14 ,  C07C25/13

CPC分类号： C07C17/02 ,  C07C17/093 ,  C07C25/13 ,  C07C41/22 ,  C07C45/63 ,  C07C67/307 ,  C07C201/12 ,  C07C231/12 ,  C07C253/30 ,  C07C317/14 ,  C07D209/08 ,  C07D209/88 ,  C07D213/57 ,  C07D213/61 ,  C07D213/75 ,  C07D213/79 ,  C07D215/18 ,  C07D279/16 ,  C07D311/16 ,  C07D453/02 ,  C07J21/008 ,  C07C69/76 ,  C07C43/225 ,  C07C25/22 ,  C07C43/29 ,  C07C25/18 ,  C07C49/813 ,  C07C69/738 ,  C07C255/50 ,  C07C233/65 ,  C07C205/12

摘要： Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species. Also disclosed is a fluorination method comprising providing, a salt comprising a cation and an aryloxylate, and SO2F2 to a reaction mixture; reacting the SO2F2 and the ammonium salt to provide a fluorinated aryl species. Further disclosed a fluorination method comprising providing a compound having the structure Ar—OH to a reaction mixture; where A is an aryl or heteroaryl; providing SO2F2 to the reaction mixture; providing a fluorinating reagent to the reaction mixture; reacting the SO2F2, the fluorinating reagent and the compound having the structure Ar—OH to provide a fluorinated aryl species having the structure Ar—F.

公开(公告)号：US20180309066A1

公开(公告)日：2018-10-25

申请号：US15955859

申请日：2018-04-18

申请人： AAC Technologies Pte, Ltd.

发明人： Zaifeng Xie

IPC分类号： H01L51/00 ,  C07C317/14 ,  C09K11/06 ,  C07D213/71

CPC分类号： H01L51/0056 ,  C07C317/14 ,  C07C2603/18 ,  C07D213/71 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1018 ,  H01L51/0067 ,  H01L51/5012 ,  H01L51/5016 ,  H01L51/5028

摘要： The invention relates to the technical field of organic luminescent materials, in particular to a spirofluorene compound and a luminescent device thereof. Spiro difluorene compounds selected freely I compounds: Y1 and Y2 denote hydrogen, electron-absorbing groups or electron-donating groups independently, respectively; at least a substituent in X1 and X2 is the substituent shown in formula II; M denotes —S—, —P—, —SO—, —SO2—, —S(═S)—, —S(═S)(═S)—, —PO—, —PO2—, —P(═S)—, —P(═S)(═S)—, —C(═O)—; N1, N2, N3 and N4 denote carbon or nitrogen atoms independently, respectively; N is an integer of 0˜4. The spirobifluorene compound of the invention has A-D-A chemical structure, and a spatial dihedral angle of nearly 90° is formed between an electron D unit and an electron-absorbing A unit, which is good for HOMO-LUMO orbital separation of thermal activation of delayed fluorescence materials, in order to obtain ideal ΔEST.

公开(公告)号：US20180244640A1

公开(公告)日：2018-08-30

申请号：US15902802

申请日：2018-02-22

申请人： AbbVie S.à.r.l. ,  Galapagos NV

发明人： Robert J. Altenbach ,  Andrew Bogdan ,  Nicolas Desroy ,  Gregory A. Gfesser ,  Stephen N. Greszler ,  Philip R. Kym ,  Bo Liu ,  Karine Fabienne Malagu ,  Nuria Merayo Merayo ,  Mathieu Rafaël Pizzonero ,  Xenia B. Searle ,  Steven Emiel Van der Plas ,  Xueqing Wang ,  Ming C. Yeung ,  Gang Zhao

IPC分类号： C07D311/04 ,  C07D311/76 ,  C07D307/81 ,  A61P11/00

CPC分类号： C07C311/51 ,  A61P11/00 ,  C07C317/14 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/06 ,  C07C2602/08 ,  C07C2602/10 ,  C07D215/48 ,  C07D307/16 ,  C07D307/81 ,  C07D311/04 ,  C07D311/76 ,  C07D317/68 ,  C07D319/22 ,  C07D405/12 ,  C07D407/12

摘要： The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

公开(公告)号：US20180201588A1

公开(公告)日：2018-07-19

申请号：US15910307

申请日：2018-03-02

申请人： Hoffmann-La Roche Inc.

发明人： Jerome Hert ,  Daniel Hunziker ,  Holger Kuehne ,  Thomas Luebbers ,  Rainer E. Martin ,  Patrizio Mattei ,  Werner Neidhart ,  Hans Richter ,  Markus Rudolph

IPC分类号： C07D249/08 ,  C07D487/04 ,  C07D249/04 ,  C07D231/20 ,  C07B41/04 ,  A61P27/02

CPC分类号： C07D249/08 ,  A61P27/02 ,  C07B41/04 ,  C07C205/04 ,  C07C255/50 ,  C07C317/14 ,  C07D231/12 ,  C07D231/20 ,  C07D231/56 ,  C07D237/14 ,  C07D249/04 ,  C07D249/12 ,  C07D401/12 ,  C07D403/12 ,  C07D407/04 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07F7/0812

摘要： The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US09968584B2

公开(公告)日：2018-05-15

申请号：US15430946

申请日：2017-02-13

申请人： Cardioxyl Pharmaceuticals, Inc.

发明人： Vincent Jacob Kalish ,  Frederick Arthur Brookfield ,  Stephen Martin Courtney ,  Lisa Marie Frost ,  John P. Toscano

IPC分类号： A61K31/341 ,  A61K9/00 ,  A61K9/08

CPC分类号： A61K31/341 ,  A61K9/0019 ,  A61K9/08 ,  A61K31/18 ,  A61K31/222 ,  A61K31/24 ,  A61K31/255 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/42 ,  A61K31/433 ,  A61K31/4436 ,  A61K31/5377 ,  A61K31/538 ,  A61K47/12 ,  A61K47/40 ,  C07C317/14 ,  C07D307/64

摘要： The disclosed subject matter provides N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

公开(公告)号：US20180050985A1

公开(公告)日：2018-02-22

申请号：US15792352

申请日：2017-10-24

申请人： The Johns Hopkins University ,  Cardioxyl Pharmaceuticals, Inc.

发明人： John P. Toscano ,  Art Sutton ,  Vincent Jacob Kalish ,  Frederick Arthur Brookfield ,  Stephen Martin Courtney ,  Lisa Marie Frost

IPC分类号： C07C311/48 ,  C07D413/04 ,  C07D317/30 ,  C07C311/51 ,  C07C317/32 ,  C07D207/06 ,  C07D213/59 ,  C07D401/04 ,  C07D213/46 ,  C07D295/192 ,  C07D295/195 ,  C07D333/34 ,  C07D309/12 ,  C07D307/82 ,  C07D295/205 ,  C07D241/08 ,  C07D233/38 ,  C07D213/74 ,  C07D213/71 ,  C07D213/40 ,  C07D211/62 ,  C07D211/58 ,  C07D211/46 ,  C07D209/48 ,  C07D207/16 ,  C07C317/14 ,  C07D241/04

CPC分类号： C07C311/48 ,  C07C311/51 ,  C07C317/14 ,  C07C317/32 ,  C07C2601/14 ,  C07D207/06 ,  C07D207/16 ,  C07D209/48 ,  C07D211/46 ,  C07D211/58 ,  C07D211/62 ,  C07D213/40 ,  C07D213/46 ,  C07D213/59 ,  C07D213/71 ,  C07D213/74 ,  C07D233/38 ,  C07D241/04 ,  C07D241/08 ,  C07D295/192 ,  C07D295/195 ,  C07D295/205 ,  C07D307/82 ,  C07D309/12 ,  C07D317/30 ,  C07D333/34 ,  C07D401/04 ,  C07D413/04

摘要： The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected, from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.