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公开(公告)号:US4567147A
公开(公告)日:1986-01-28
申请号:US683867
申请日:1984-12-20
IPC分类号: A61K39/285 , C12N7/08
CPC分类号: C12N7/00 , A61K39/12 , A61K39/285 , C12N2710/24134 , C12N2710/24164 , Y10S424/821
摘要: The present invention discloses an attenuated smallpox vaccine strain exhibiting antibody production similar to conventional strains but without postvaccinal side effects. The vaccine is prepared by attenuating a Lister strain of a vaccinia virus by cell culture and selecting a suitable strain therefrom showing relatively small and uniform pocks on the chorioallantoic membrane of an embryonated egg.
摘要翻译: 本发明公开了一种减毒天花疫苗菌株,其表现出与常规菌株相似但不具有后阴道副作用的抗体产生。 疫苗通过细胞培养减毒痘苗病毒的Lister菌株并从其中选择合适的菌株来制备,其在胚胎卵的绒毛尿囊膜上显示相对较小且均匀的斑点。