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公开(公告)号：US20080317840A1
公开(公告)日：2008-12-25
申请号：US12135828
申请日：2008-06-09
CPC分类号： A61K31/704 , A61K9/1271 , A61K9/1273 , A61K31/12
摘要： The present invention provides liposomal compositions and methods of using such compositions in vitro and in vivo. In particular, the present invention provides stable, polymer-caged liposomes comprising a pH responsive delivery mechanism for delivery of nucleic acids, peptides, small molecules, drugs, etc. in vitro and in vivo.
摘要翻译： 本发明提供在体外和体内使用这些组合物的脂质体组合物和方法。 特别地，本发明提供了稳定的聚合物封闭的脂质体，其包含用于在体外和体内递送核酸，肽，小分子，药物等的pH响应递送机制。
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公开(公告)号：US20070131915A1
公开(公告)日：2007-06-14
申请号：US11600679
申请日：2006-11-16
申请人： Sasha Stankovich , Sonbinh Nguyen , Rodney Ruoff
发明人： Sasha Stankovich , Sonbinh Nguyen , Rodney Ruoff
IPC分类号： H01B1/24
CPC分类号： H01B1/24 , C01B32/225
摘要： A method of making a dispersion of reduced graphite oxide nanoplatelets involves providing a dispersion of graphite oxide nanoplatelets and reducing the graphite oxide nanoplatelets in the dispersion in the presence of a reducing agent and a polymer. The reduced graphite oxide nanoplatelets are reduced to an extent to provide a higher C/O ratio than graphite oxide. A stable dispersion having polymer-treated reduced graphite oxide nanoplatelets dispersed in a dispersing medium, such as water or organic liquid is provided. The polymer-treated, reduced graphite oxide nanoplatelets can be distributed in a polymer matrix to provide a composite material.
摘要翻译： 制备还原性氧化石墨纳米片的分散体的方法包括在还原剂和聚合物的存在下提供石墨氧化物纳米片的分散体并还原分散体中的氧化石墨纳米片。 还原的氧化石墨纳米片减少到提供比氧化石墨更高的C / O比的程度。 提供了分散在分散介质如水或有机液体中的具有聚合物处理的还原性氧化石墨纳米片的稳定分散体。 聚合物处理的还原性氧化石墨纳米片可以分布在聚合物基质中以提供复合材料。
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公开(公告)号：US20060241317A1
公开(公告)日：2006-10-26
申请号：US11472137
申请日：2006-06-20
申请人： Robert Grubbs , Peter Schwab , Sonbinh Nguyen
发明人： Robert Grubbs , Peter Schwab , Sonbinh Nguyen
IPC分类号： C07F15/00
CPC分类号： C08F4/80 , B01J31/18 , B01J31/2265 , B01J31/24 , B01J31/2404 , B01J2231/14 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07F15/002 , C07F15/0046 , C08F32/00 , C08G61/08
摘要： Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The carbene compounds are of the formula where M is Os or Ru; R is hydrogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl; X and X are independently selected from any anionic ligand; and L and L are independently selected from any neutral electron donor. The ruthenium and osmium carbene compounds of the present invention may be synthesized using diazo compounds, by neutral electron donor ligand exchange, by cross metathesis, using acetylene, using cumulated olefins, and in a one-pot method using diazo compounds and neutral electron donors. The ruthenium and osmium carbene compounds of the present invention may be used to catalyze olefin metathesis reactions including, but not limited to, ROMP, RCM, depolymerization of unsaturated polymers, synthesis of telechelic polymers, and olefin synthesis.
摘要翻译： 公开了在各种官能团存在下稳定并且可用于催化非限制性环状和无环烯烃上的烯烃复分解反应的钌和锇卡宾化合物。 还公开了制备卡宾化合物的方法。 卡宾化合物具有下式：其中M是Os或Ru; R 1是氢; R选自氢，取代或未取代的烷基和取代或未取代的芳基; X和X 1独立地选自任何阴离子配体; L和L 1独立地选自任何中性电子给体。 本发明的钌和锇卡宾化合物可以使用重氮化合物，通过中性电子给体配体交换，通过交叉复分解，使用乙炔，使用累积的烯烃，以及使用重氮化合物和中性电子给体的一锅法合成。 本发明的钌和锇卡宾化合物可用于催化烯烃复分解反应，包括但不限于ROMP，RCM，不饱和聚合物的解聚，遥爪聚合物的合成和烯烃合成。
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公开(公告)号：US08821922B2
公开(公告)日：2014-09-02
申请号：US12135828
申请日：2008-06-09
IPC分类号： A61K9/127
CPC分类号： A61K31/704 , A61K9/1271 , A61K9/1273 , A61K31/12
摘要： The present invention provides liposomal compositions and methods of using such compositions in vitro and in vivo. In particular, the present invention provides stable, polymer-caged liposomes comprising a pH responsive delivery mechanism for delivery of nucleic acids, peptides, small molecules, drugs, etc. in vitro and in vivo.
摘要翻译： 本发明提供在体外和体内使用这些组合物的脂质体组合物和方法。 特别地，本发明提供了稳定的聚合物封闭的脂质体，其包含用于在体外和体内递送核酸，肽，小分子，药物等的pH响应递送机制。
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公开(公告)号：US20050113590A1
公开(公告)日：2005-05-26
申请号：US10968361
申请日：2004-10-18
申请人： Robert Grubbs , Peter Schwab , Sonbinh Nguyen
发明人： Robert Grubbs , Peter Schwab , Sonbinh Nguyen
IPC分类号： B01J31/24 , B01J31/22 , C07F9/50 , C07F15/00 , C07F19/00 , C08F4/42 , C08F4/80 , C08F8/50 , C08F32/00 , C08G61/02 , C08G61/08
CPC分类号： C08F4/80 , B01J31/18 , B01J31/2265 , B01J31/24 , B01J31/2404 , B01J2231/14 , B01J2231/543 , B01J2531/821 , B01J2531/825 , C07F15/002 , C07F15/0046 , C08F32/00 , C08G61/08
摘要： Ruthenium and osmium carbens compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic olefins are disclosed. Also disclosed are methods of making the carbene compounds. The carbene compounds are of the formula where M is Os or Ru; R1 is hydrogen; R is selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, and substituted or unsubstituted aryl; X and X1 are independently selected from any anionic ligand; and L and L1 are independently selected from any neutral electron donor. The ruthenium and osmium carbene compounds of the present invention may be synthesized using diazo compounds, by neutral electron donor ligand exchange, by cross metathesis, using acetylene, using cumulated olefins, and in a one-pot method using diazo compounds and neutral electron donors. The ruthenium and osmium carbene compounds of the present invention may be used to catalyze olefin metathesis reactions including, but not limited to, ROMP, RCM, depolymerization of unsaturated polymers, synthesis of telechelic polymers, and olefin synthesis.
摘要翻译： 公开了在各种官能团存在下稳定并且可用于催化未应变的环状和无环烯烃上的烯烃复分解反应的钌和锇碳化物化合物。 还公开了制备卡宾化合物的方法。 卡宾化合物具有下式：其中M是Os或Ru; R 1是氢; R选自氢，取代或未取代的烷基和取代或未取代的芳基; X和X 1独立地选自任何阴离子配体; L和L 1独立地选自任何中性电子给体。 本发明的钌和锇卡宾化合物可以使用重氮化合物，通过中性电子给体配体交换，通过交叉复分解，使用乙炔，使用累积的烯烃，以及使用重氮化合物和中性电子给体的一锅法合成。 本发明的钌和锇卡宾化合物可用于催化烯烃复分解反应，包括但不限于ROMP，RCM，不饱和聚合物的解聚，遥爪聚合物的合成和烯烃合成。
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