公开(公告)号：US07658886B2

公开(公告)日：2010-02-09

申请号：US10838588

申请日：2004-05-04

申请人： Stéphane Jean Marie Olivier ,  Gerard Muller ,  Jeffrey S. Busnach

发明人： Stéphane Jean Marie Olivier ,  Gerard Muller ,  Jeffrey S. Busnach

IPC分类号： B01L1/00

CPC分类号： B01L3/50255 ,  B01L2200/02 ,  B01L2200/12 ,  B01L2300/0829 ,  B01L2400/0409 ,  B01L2400/0487

摘要： The present invention relates to a multiwell plate having a series of wells, each well having an inner bore, an open top and a bottom, the bottom being sealed with a liquid permeable filter, and an insert contained within the inner bore of each well, each insert having an outer dimension the same or larger than that of the inner bore and a through bore of a dimension less than that of the outer dimension of the insert. The use of inserts allows one to take a standard one-piece plate design with a heat sealed membrane and arrange for a universal plate format. The insert may act as a base for an extension plate that can be adhered, heat sealed or overmolded over the plate top and insert top to form a deep well plate. The plate conforms to the Society of Biological Standards Microplate Standards. Additionally, the inserts may be configured to give one a different well diameter (smaller, tapered, etc), to include various media such as chromatography resins, to include multiple layers of membrane and the like. A variety of inserts may be used in the same plate to create a minilab on a plate that is capable of conducting several steps of a process on the same (e.g (e.g. filter, wash, bind, elute, label, etc).

摘要翻译： 本发明涉及具有一系列井的多孔板，每个孔具有内孔，开口顶部和底部，底部用液体可渗透的过滤器密封，以及包含在每个孔的内孔内的插入件， 每个插入件具有与内孔相同或更大的外部尺寸和尺寸小于插入件的外部尺寸尺寸的通孔。 使用插入件可以使用带有热密封膜的标准单片板设计，并安排通用板格式。 插入件可以用作延伸板的基部，该延伸板可以在板顶上粘附，热密封或包覆成型，并且插入顶部以形成深孔板。 该板符合生物标准微孔板标准协会。 此外，插入件可以被配置成给出一个不同的孔直径（更小，锥形等），以包括各种介质，例如色谱树脂，以包括多层膜等。 可以在同一板中使用各种插入物以在板上产生能够在相同的过程上进行几个步骤（例如过滤器，洗涤，结合，洗脱，标记等）的小拉伸。

公开(公告)号：US07063216B2

公开(公告)日：2006-06-20

申请号：US10655052

申请日：2003-09-04

申请人： Joseph P. Lane ,  Louis L. Bonhomme ,  Douglas A. Boucher ,  Richard T. Burnham ,  Kenneth G. Desilets ,  Luc Lirot ,  Stéphane Jean Marie Olivier ,  Steven D. Sheridan

发明人： Joseph P. Lane ,  Louis L. Bonhomme ,  Douglas A. Boucher ,  Richard T. Burnham ,  Kenneth G. Desilets ,  Luc Lirot ,  Stéphane Jean Marie Olivier ,  Steven D. Sheridan

IPC分类号： B01D63/00 ,  B01D24/42 ,  B01D29/92

CPC分类号： B01L3/50255 ,  B01L2300/0848

摘要： The present invention provides an underdrain having an improved spout. The underdrain has particular utility in the construction of both single-well and microarray filtration devices. In a principal embodiment, the underdrain is characterized by its incorporation of a straight-walled, roughly-textured spout, the spout being provided with microhole(s) at a terminal end thereof for the discharge of fluid conducted through the underdrain. An array comprising several of such underdrains can be mated with a corresponding array of wells, with separation material (e.g., membrane material) provided therebetween. The resultant microarray filtration device can be used for conducting several fluid assays contemporaneously with, for example, good “pendant drop” control and low “cross-talk”.

摘要翻译： 本发明提供了一种具有改进的喷口的暗渠。 缺水在单井和微阵列过滤装置的构建中具有特殊的用途。 在一个主要实施方案中，缺油的特征在于其结合了直壁的大致纹理的喷口，喷嘴在其末端处设置有微孔，用于排出通过漏斗传导的流体。 包括若干这样的下水道的阵列可以与相应的孔阵列配合，其间设置有分离材料（例如膜材料）。 所得到的微阵列过滤装置可用于与例如良好的“悬滴”控制和低“串扰”同时进行几种流体测定。