公开(公告)号：US20080226018A1

公开(公告)日：2008-09-18

申请号：US12126224

申请日：2008-05-23

Applicant: Larry D. Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

Inventor： Larry D. Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

IPC: A61B6/00

CPC classification number: A61B6/4241 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/482 ,  A61B6/502 ,  A61B6/507

Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.

Abstract translation: 使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。 使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取 多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器，其生成尺寸为0.4mm的三维计算机断层摄影图像数据集 或至少两个正交方向。

公开(公告)号：US20130071333A1

公开(公告)日：2013-03-21

申请号：US13623098

申请日：2012-09-19

Applicant: Larry PARTAIN ,  Mingshan SUN ,  Edward J. SEPPI ,  Raisa PAVLYUCHKOVA ,  Arundhuti GANGULY ,  Stavros PRIONAS ,  James E. CLAYTON

Inventor： Larry PARTAIN ,  Mingshan SUN ,  Edward J. SEPPI ,  Raisa PAVLYUCHKOVA ,  Arundhuti GANGULY ,  Stavros PRIONAS ,  James E. CLAYTON

IPC: A61K49/04

CPC classification number: G06F19/3431 ,  G06F19/00 ,  G06K9/6277 ,  G06K2209/053 ,  G16H50/30

Abstract: Techniques described herein generally relate to identifying, assessing, and managing cancer growth rates and potential metastasis. Some example methods may include constructing one or more quantitative metrics for the potential metastasis in a selected population of other patients, acquiring a first set of numeric biomarker data for the patient before having placed a biomarker in the patient, acquiring a second set of numeric biomarker data for the patient after having placed the biomarker in the patient, determining a set of biomarker surrogate values for microvessel density information based on a mean numeric biomarker difference derived from the first set of numeric biomarker data and the second set of numeric biomarker data, determining a set of biomarker surrogate values for microvessel density information based on a mean numeric biomarker difference derived from the first set of numeric biomarker data and the second set of numeric biomarker data, and predicting quantitative and objective risk for the cancer growth rates and potential metastasis and adjusting a treatment plan based on the biomarker surrogate values and at least one of the one or more quantitative metrics.

Abstract translation: 本文描述的技术通常涉及鉴定，评估和管理癌症生长速度和潜在转移。 一些示例性方法可以包括为所选择的其他患者群体中的潜在转移构建一个或多个定量度量，在将患者的生物标志物置于患者体内之前获取患者的第一组数值生物标志物数据，获取第二组数值生物标志物 基于从第一组数字生物标志物数据和第二组数值生物标志物数据导出的平均数值生物标志物差异，确定用于微血管密度信息的生物标记替代值的集合，确定患者的数据;确定 基于从第一组数值生物标志物数据和第二组数值生物标志物数据得出的平均数值生物标志物差异的微血管密度信息的一组生物标志物替代值，并预测癌症生长速率和潜在转移的定量和客观风险， 根据生物标志物代理调整治疗计划 值和至少一个一个或多个定量度量。

公开(公告)号：US07660384B2

公开(公告)日：2010-02-09

申请号：US12126224

申请日：2008-05-23

Applicant: Larry Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

Inventor： Larry Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

IPC: A61B6/04

CPC classification number: A61B6/4241 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/482 ,  A61B6/502 ,  A61B6/507

Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.

Abstract translation: 使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。 使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取 多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器生成三维计算机断层摄影图像数据集，其解析尺寸为0.4mm的体素 或至少两个正交方向。

公开(公告)号：US08483803B2

公开(公告)日：2013-07-09

申请号：US12210813

申请日：2008-09-15

Applicant: Larry Partain ,  Hassan Mostafavi ,  Stavros Prionas

Inventor： Larry Partain ,  Hassan Mostafavi ,  Stavros Prionas

IPC: A61B6/00

CPC classification number: A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1061 ,  G06K9/3241 ,  G06K2209/053 ,  G06T7/74

Abstract: A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, wherein the contrast-enhanced image and the non-contrast-enhanced image are created at different times, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image. A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image, wherein the act of determining the position is performed is substantially real time.

Abstract translation: 一种用于医疗过程的方法包括获得患者的一部分的对比度增强图像，患者的该部分具有物体，获得该部分的非对比度增强图像，其中对比度增强图像和 在不同时间创建非对比度增强图像，并且使用对比度增强图像和非对比度增强图像来确定对象的位置。 一种用于医疗过程的方法包括获得患者的一部分的对比度增强图像，患者的部分具有物体，获得该部分的非对比度增强图像，以及确定该对象的位置 使用对比度增强图像和非对比度增强图像，其中执行确定位置的动作基本上是实时的。

公开(公告)号：US07394889B2

公开(公告)日：2008-07-01

申请号：US11437076

申请日：2006-05-18

Applicant: Larry D. Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

Inventor： Larry D. Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

IPC: A61B6/04

CPC classification number: A61B6/4241 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/482 ,  A61B6/502 ,  A61B6/507

Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.

Abstract translation: 使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。 使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取 多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器，其生成尺寸为0.4mm的三维计算机断层摄影图像数据集 或至少两个正交方向。

公开(公告)号：US20070269000A1

公开(公告)日：2007-11-22

申请号：US11437076

申请日：2006-05-18

Applicant: Larry Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

Inventor： Larry Partain ,  Stavros Prionas ,  Edward Seppi ,  Robert Sutherland ,  David Humber ,  Hassan Mostafavi ,  Felix Fernando ,  John Boone

IPC: A61B6/04

CPC classification number: A61B6/4241 ,  A61B6/032 ,  A61B6/4085 ,  A61B6/482 ,  A61B6/502 ,  A61B6/507

Abstract: A method of imaging a patient's uncompressed region of interest using X-ray cone beam computed tomography or cone beam digital tomography comprises the step of introducing an effective amount of a contrast agent to the uncompressed region of interest. A system for imaging a patient's uncompressed region of interest using cone beam computed tomography (CBCT) or cone beam digital tomography (CBDT) comprises an X-ray source transmitting an X-ray to the uncompressed region of interest, an image acquisition system acquiring a plurality of two-dimensional projection images data for a CBCT or CBDT data set with at least one of the projection images acquired in 35 milliseconds or less, and a processor generating a three-dimensional computed tomography image data set resolving voxels with dimensions of 0.4 mm or less in at least two orthogonal directions.

Abstract translation: 使用X射线锥束计算机断层摄影或锥束数字断层摄影术对患者未压缩感兴趣区域成像的方法包括将有效量的造影剂引入未压缩感兴趣区域的步骤。 使用锥形束计算机断层摄影（CBCT）或锥束数字断层摄影（CBDT）对患者未压缩感兴趣区域成像的系统包括将X射线发射到感兴趣的未压缩区域的X射线源，获取 多个用于CBCT或CBDT数据集的二维投影图像数据，其具有在35毫秒或更短时间内获取的至少一个投影图像，以及处理器，其生成尺寸为0.4mm的三维计算机断层摄影图像数据集 或至少两个正交方向。

公开(公告)号：US10380736B1

公开(公告)日：2019-08-13

申请号：US15290951

申请日：2016-10-11

Applicant: Larry Partain ,  George Zentai ,  Stavros Prionas ,  Raisa Pavlyuchkova

Inventor： Larry Partain ,  George Zentai ,  Stavros Prionas ,  Raisa Pavlyuchkova

IPC: G06K9/00 ,  G06T7/00 ,  G06T17/20

Abstract: Methods of obtaining a suspect nodules' sizes and/or growth rate are provided. In one embodiment, the method begins with at a first time: (i) obtaining a first three dimensional (3D) data set cube of voxels of a patient's anatomy including nodules; (ii) creating a second 3D data set cube of the same size as the first where all voxel values are set to zero; (iii) creating multiple Maximum-Intensity-Projection (MIP) images from the first 3D data set cube taken at different angles; (iv) replacing those voxels in the second 3D data set cube with corresponding voxels from the first 3D data set cube that provide non-zero values in the multiple MIP images; and (v) converting data in the second 3D data set cube into closed surface volumes, cross sectional areas or linear dimensions using image segmentation. Data from a second time can be used to determine growth rate.

公开(公告)号：US08036435B2

公开(公告)日：2011-10-11

申请号：US11864856

申请日：2007-09-28

Applicant: Larry Partain ,  Stavros Prionas ,  John Boone

Inventor： Larry Partain ,  Stavros Prionas ,  John Boone

IPC: G06K9/00

CPC classification number: G06T7/0012 ,  G06T7/11 ,  G06T2207/30096

Abstract: A method of analyzing a volumetric data set obtained by an imaging system from an object is provided includes defining a first region of interest comprising a population of voxels of a first tissue part of the object to obtain a first distribution of radiation attenuation coefficient values, defining a second region of interest comprising a sample of voxels of a second tissue part of the object to obtain a second distribution of radiation attenuation coefficient values, and distinguishing the second tissue from the first tissue using the properties of the first and second distributions of radiation attenuation coefficients.

Abstract translation: 提供了一种从对象中分析由成像系统获得的体数据集的方法，包括定义第一感兴趣区域，其包括物体的第一组织部分的体素群，以获得辐射衰减系数值的第一分布，定义 第二感兴趣区域包括物体的第二组织部分的体素样本以获得辐射衰减系数值的第二分布，以及使用辐射衰减的第一和第二分布的特性来区分第二组织和第一组织 系数。

公开(公告)号：US09387342B2

公开(公告)日：2016-07-12

申请号：US12176974

申请日：2008-07-21

Applicant: Stavros Prionas ,  Michael C. Green ,  Edward Seppi ,  Larry D. Partain ,  James Clayton ,  Stanley Mansfield ,  John Boone

Inventor： Stavros Prionas ,  Michael C. Green ,  Edward Seppi ,  Larry D. Partain ,  James Clayton ,  Stanley Mansfield ,  John Boone

IPC: A61N5/00 ,  A61N5/10

CPC classification number: A61N5/1084 ,  A61N5/10 ,  A61N5/1048 ,  A61N5/1081

Abstract: A method of delivering external radiation beams to a target volume in a body portion includes positioning a radioactive isotope source at a plurality of locations spaced apart around the body portion, and collimating radiation beams of the radioactive isotope source from the plurality of locations, whereby the target volume in the body portion is deposited with a predetermined dose distribution. A radiation device employs a member having a configuration adapted to surround a body portion to be irradiated. The member has a channel and a plurality of collimators spaced apart along and coupled to the channel. The plurality of collimators define a plurality of dwelling locations for a radioactive isotope source in the channel and are configured to collimate radiation beams of the radioactive isotope source.

Abstract translation: 将外部辐射束输送到身体部分中的目标体积的方法包括：将放射性同位素源定位在围绕身体部分间隔开的多个位置处，以及从多个位置准直放射性同位素源的辐射束，由此 以预定剂量分布沉积身体部分中的目标体积。 辐射装置采用具有适于包围待照射的主体部分的构造的构件。 该构件具有通道和多个准直器，沿着并且耦合到通道间隔开。 多个准直器限定了通道中的放射性同位素源的多个住宅位置，并且被配置成准直放射性同位素源的辐射束。

公开(公告)号：US20100069742A1

公开(公告)日：2010-03-18

申请号：US12210813

申请日：2008-09-15

Applicant: Larry PARTAIN ,  Hassan MOSTAFAVI ,  Stavros PRIONAS

Inventor： Larry PARTAIN ,  Hassan MOSTAFAVI ,  Stavros PRIONAS

IPC: A61B5/05 ,  G06K9/00

CPC classification number: A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1061 ,  G06K9/3241 ,  G06K2209/053 ,  G06T7/74

Abstract: A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, wherein the contrast-enhanced image and the non-contrast-enhanced image are created at different times, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image. A method for use in a medical procedure includes obtaining a contrast-enhanced image of a portion of a patient, the portion of the patient having an object, obtaining a non-contrast-enhanced image of the portion, and determining a position of the object using the contrast-enhanced image and the non-contrast-enhanced image, wherein the act of determining the position is performed is substantially real time.

Abstract translation: 一种用于医疗过程的方法包括获得患者的一部分的对比度增强图像，患者的该部分具有物体，获得该部分的非对比度增强图像，其中对比度增强图像和 在不同时间创建非对比度增强图像，并且使用对比度增强图像和非对比度增强图像来确定对象的位置。 一种用于医疗过程的方法包括获得患者的一部分的对比度增强图像，患者的部分具有物体，获得该部分的非对比度增强图像，以及确定该对象的位置 使用对比度增强图像和非对比度增强图像，其中执行确定位置的动作基本上是实时的。