公开(公告)号：US09241795B2

公开(公告)日：2016-01-26

申请号：US14236740

申请日：2012-09-05

申请人： Andre Schöne ,  Jens Fischer ,  Karsten Schröder ,  Hartmut Steffen ,  Wilfried Besch ,  Andreas Vogelsang ,  Klaus-Dieter Weltmann ,  Barbara Nebe ,  Steffi Schroder ,  Beatrix Fett

发明人： Andre Schöne ,  Jens Fischer ,  Karsten Schröder ,  Hartmut Steffen ,  Wilfried Besch ,  Andreas Vogelsang ,  Klaus-Dieter Weltmann ,  Barbara Nebe

IPC分类号： A61F2/28 ,  B05D1/02 ,  A61K6/02 ,  C04B41/83 ,  C04B41/00 ,  C04B41/48 ,  A61L27/10 ,  A61L31/02 ,  C04B111/00

CPC分类号： A61F2/28 ,  A61K6/0205 ,  A61L27/10 ,  A61L31/026 ,  A61L2400/18 ,  A61L2430/02 ,  A61L2430/12 ,  C04B41/009 ,  C04B41/48 ,  C04B41/83 ,  C04B2111/00836 ,  C04B35/00 ,  C04B35/18 ,  C04B41/0054

摘要： A process for manufacturing a ceramic implant with a surface which forms a permanent bonding to bone cell tissues, the surface providing improved osseointegration, the process comprising the step of:—a pretreatment of the ceramic material with the surface wherein said surface of the ceramic material is exposed to a conditioning plasma, which is produced by means of direct current (DC) or alternating current (AC), such as high or radio frequency (HF, RF), or microwaves (MW) at a low pressure, followed by a second step;—a treatment with a reactive plasma in which an organic compound is added to the plasma for the at least partial application of an organic phase to said surface wherein the organic compound is selected from the group consisting of aliphatic amines, cyclic amines, unsaturated and aromatic amines as well as combinations thereof.

摘要翻译： 一种用于制造具有与骨细胞组织永久结合的表面的陶瓷植入物的方法，所述表面提供改善的骨整合，所述方法包括以下步骤： - 用陶瓷材料的表面预处理陶瓷材料的所述表面 暴露于通过直流（DC）或交流电（AC）如低压下的高频或射频（HF，RF）或微波（MW）产生的调理等离子体，随后是 第二步：用反应性等离子体处理，其中向所述等离子体中加入有机化合物至少部分地施加到所述表面，其中所述有机化合物选自脂族胺，环胺， 不饱和和芳族胺以及它们的组合。