公开(公告)号：US12070391B2

公开(公告)日：2024-08-27

申请号：US17839092

申请日：2022-06-13

申请人： SINTX Technologies, Inc.

发明人： Bryan J. McEntire ,  Ryan M. Bock

IPC分类号： A61F2/30 ,  A61F2/34 ,  A61L27/10 ,  A61F2/36 ,  A61L31/02

CPC分类号： A61F2/30767 ,  A61F2/3094 ,  A61F2/34 ,  A61L27/10 ,  A61F2/36 ,  A61F2310/00317 ,  A61L31/026 ,  A61L2400/10 ,  A61L2420/02 ,  A61L2430/24

摘要： Methods for improving the wear performance of silicon nitride and/or other ceramic materials, particularly to make them more suitable for use in manufacturing biomedical implants.

公开(公告)号：US11904073B2

公开(公告)日：2024-02-20

申请号：US17975245

申请日：2022-10-27

申请人： Verily Life Sciences LLC

发明人： Alexander Loo ,  Damiano Patron ,  Matthew Page

IPC分类号： A61N1/02 ,  A61N1/05 ,  A61N1/08 ,  A61N1/372 ,  A61N1/375 ,  H05K1/02 ,  H05K1/18 ,  H05K3/00 ,  H01G4/005 ,  H01G4/018 ,  H01G4/12 ,  H01G4/30 ,  H01G4/35 ,  H01G4/40 ,  H01G4/224 ,  H01G4/228 ,  H01G4/236 ,  A61L31/02 ,  H01R4/02 ,  H01R4/60 ,  H01R43/02 ,  H05K3/32 ,  H01R4/04 ,  H01Q1/27 ,  H01Q23/00 ,  H01R12/53

CPC分类号： A61L31/026 ,  H01Q1/273 ,  H01Q23/00 ,  H01R4/029 ,  H01R4/04 ,  H01R4/60 ,  H01R12/53 ,  H01R43/0256 ,  H05K1/18 ,  H05K3/0047 ,  H05K3/321 ,  H05K3/328 ,  H05K2201/10257 ,  H05K2201/10295 ,  H05K2203/049

摘要： A biocompatible electrical connection includes a substrate; a ferrule having a concentric flange at a first end of the ferrule; a first adhesive; and a second adhesive. The first adhesive adheres a first surface of the concentric flange of the ferrule to a surface of the substrate. The second adhesive fills an annular space between a hole in the substrate and the ferrule. The first adhesive or the second adhesive forms a conductive path on the surface of the substrate between the ferrule and a circuit pattern on the substrate.

公开(公告)号：US20240001006A1

公开(公告)日：2024-01-04

申请号：US17854555

申请日：2022-06-30

申请人： MEDOS INTERNATIONAL SARL

发明人： Thomas M. DiMauro

IPC分类号： A61L31/08 ,  A61B17/70 ,  A61L31/02 ,  A61L31/16

CPC分类号： A61L31/088 ,  A61B17/7001 ,  A61L31/026 ,  A61L31/16 ,  A61L2300/404 ,  A61L2400/12

摘要： A method of making a biomedical implant comprising the steps of contacting a biomedical implant having a surface comprising titanium with an acidic solution comprising a titanium precursor capable of hydrolysis to titanium for a time sufficient to epitaxially grow titania nanorods on the surface. Preferably, the titanium precursor is selected from the group consisting of titanium butoxide, TTIP and titanium tetrachloride. Carrying out the method provides a biomedical implant having a surface having nanorods comprising at least 50% titania extending therefrom, wherein the nanorods terminate in a substantially conical tip, wherein the nanorods have a density on the implant of at least 10 nanorods/um2.

公开(公告)号：US20180272042A1

公开(公告)日：2018-09-27

申请号：US15933293

申请日：2018-03-22

申请人： Brown University

发明人： David Borton ,  Elaina Atherton ,  Vicki Colvin

IPC分类号： A61L31/06 ,  A61L31/16 ,  A61L31/02 ,  A61L31/04 ,  A61K31/05 ,  A61B5/04 ,  A61B17/68 ,  A61C8/00 ,  A61F2/00 ,  A61F2/14 ,  A61N1/375

CPC分类号： A61L31/06 ,  A61B5/04001 ,  A61B17/68 ,  A61B2017/561 ,  A61C8/0013 ,  A61C19/06 ,  A61F2/0077 ,  A61F2/14 ,  A61F2002/183 ,  A61F2250/0067 ,  A61K31/05 ,  A61L27/14 ,  A61L27/54 ,  A61L31/026 ,  A61L31/04 ,  A61L31/048 ,  A61L31/16 ,  A61L2300/102 ,  A61L2300/41 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/08 ,  A61N1/05 ,  A61N1/375 ,  A61N1/37512

摘要： A polymer film coating for medical devices and medical devices with coating are provided to controllably release one or more therapeutics or other agents locally at the tissue-device interface for a prolonged period of time. The coating can be prepared via layer by layer (LbL) assembly of polymers and/or polymers conjugated to or otherwise associated with one or more drugs, particularly recyclable antioxidants or antioxidant regulators. The resulting coating contains alternating layers that are assembled via electrostatic interactions, hydrogen bonding, or other secondary interactions. The coated device can provide for long term local delivery of antioxidants, preferably antioxidant upregulators and/or recyclable antioxidants, to modulate the oxidative stress associated with brain implants.

公开(公告)号：US09968715B2

公开(公告)日：2018-05-15

申请号：US14911077

申请日：2014-08-01

申请人： Fraunhofer-Gesellschaft Zur Förderung Der Angewandten Forschung E.V.

发明人： Andreas Keil ,  Ralph Wilken ,  Jörg Ihde ,  Thomas Lukasczyk ,  Dirk Salz ,  Jost Degenhardt

IPC分类号： A61L31/08 ,  A61L27/30 ,  A61L27/50 ,  A61L31/14 ,  A61B17/70 ,  A61B17/80 ,  A61B17/84 ,  A61B17/86 ,  A61L31/02 ,  C23C16/48 ,  C23C16/50

CPC分类号： A61L31/088 ,  A61B17/7049 ,  A61B17/80 ,  A61B17/846 ,  A61B17/848 ,  A61B17/866 ,  A61L27/306 ,  A61L27/50 ,  A61L31/022 ,  A61L31/026 ,  A61L31/14 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2430/02 ,  A61L2430/38 ,  C23C16/483 ,  C23C16/50

摘要： The invention relates to medical technology products, for example a medical implant or a medical instrument, having colored markings based on titanium oxides, to the use of coatings based on titanium oxides for the production of coated materials, such as medical technology products, in particular for titanium oxide-based coating for the colored marking of the surface of medical technology products, and to a method for depositing colored markings based on titanium oxides on medical technology products.

公开(公告)号：US20180072604A1

公开(公告)日：2018-03-15

申请号：US15819855

申请日：2017-11-21

申请人： MO SCI, CORP.

发明人： Steven Jung

IPC分类号： C03B19/06 ,  C03C4/00 ,  A61F2/28 ,  A61L24/00 ,  A61L15/08 ,  A61L31/14 ,  A61L31/02 ,  A61L27/56 ,  A61L27/10 ,  C03B19/10 ,  C03C3/04 ,  A61L27/54 ,  A61L27/58 ,  C03B32/02 ,  C03C11/00 ,  A61L24/02

CPC分类号： C03B19/06 ,  A61F2/28 ,  A61L15/08 ,  A61L24/0036 ,  A61L24/02 ,  A61L27/10 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/026 ,  A61L31/146 ,  A61L2300/102 ,  A61L2430/02 ,  A61L2430/34 ,  C03B19/108 ,  C03B19/109 ,  C03B32/02 ,  C03C3/04 ,  C03C4/0007 ,  C03C4/0014 ,  C03C11/00 ,  C03C2204/00 ,  Y10T428/315

摘要： A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.

公开(公告)号：US20180071011A1

公开(公告)日：2018-03-15

申请号：US15695642

申请日：2017-09-05

申请人： I.C. Medical, Inc.

发明人： Ioan Cosmescu

IPC分类号： A61B18/14 ,  A61L31/02

CPC分类号： A61B18/14 ,  A61B18/1402 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00601 ,  A61B2018/1253 ,  A61B2018/1412 ,  A61L31/022 ,  A61L31/026

摘要： Electrosurgery blades including electrosurgery blade assemblies having argon beam capability. The electrosurgery blade includes a non-conductive planar member having opposite planar sides with a bottom angled sharp cutting edge, and a conductive layer located on one or both of the opposing planar sides of the non-conductive planar member where the conductive layer lies adjacent to the angled sharp cutting edge of the non-conductive planar member without covering the angled sharp cutting edge. In embodiments of the electrosurgery blade assemblies having argon beam capability, the electrosurgery blade assembly includes a non-conductive tube member having a hollow tubular shaped opening and a slot where at least a portion of the conductive layer of the electrosurgery blade is positioned within the slot of the non-conductive tube member.

公开(公告)号：US09850157B2

公开(公告)日：2017-12-26

申请号：US14692378

申请日：2015-04-21

申请人： MO SCI, CORP.

发明人： Steven Jung

IPC分类号： A61F2/28 ,  C03B19/06 ,  C03C4/00 ,  C03C11/00 ,  A61L27/10 ,  A61L27/56 ,  A61L31/02 ,  A61L31/14 ,  A61L15/08 ,  A61L24/00 ,  A61L24/02 ,  C03B19/10 ,  A61L27/54 ,  A61L27/58 ,  C03B32/02 ,  C03C3/04

CPC分类号： C03B19/06 ,  A61F2/28 ,  A61L15/08 ,  A61L24/0036 ,  A61L24/02 ,  A61L27/10 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L31/026 ,  A61L31/146 ,  A61L2300/102 ,  A61L2430/02 ,  A61L2430/34 ,  C03B19/108 ,  C03B19/109 ,  C03B32/02 ,  C03C3/04 ,  C03C4/0007 ,  C03C4/0014 ,  C03C11/00 ,  C03C2204/00 ,  Y10T428/315

摘要： A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration. The open porosity present inside the bead will allow for enhanced degradability in-vivo as compared to solid particles or spheres and also promote the growth of tissues including but not limited to all types of bone, soft tissue, blood vessels, and nerves.

公开(公告)号：US09474831B2

公开(公告)日：2016-10-25

申请号：US12931926

申请日：2011-02-14

申请人： Edward S. Boyden ,  Roy P. Diaz ,  Roderick A. Hyde ,  Jordin T. Kare ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

发明人： Edward S. Boyden ,  Roy P. Diaz ,  Roderick A. Hyde ,  Jordin T. Kare ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

IPC分类号： A61L2/00 ,  A61L29/08 ,  A61L2/232 ,  A61L2/24 ,  A61L2/26 ,  A61L27/54 ,  A61L31/08 ,  A61L17/14 ,  A61L27/28 ,  A61L27/30 ,  A61L29/00 ,  A61L29/16 ,  B82Y5/00 ,  B82Y30/00 ,  A61L2/08 ,  A61L2/14 ,  B82Y40/00

CPC分类号： A61L2/24 ,  A61L2/0011 ,  A61L2/08 ,  A61L2/14 ,  A61L2/232 ,  A61L2/26 ,  A61L17/145 ,  A61L27/28 ,  A61L27/306 ,  A61L27/54 ,  A61L29/00 ,  A61L29/08 ,  A61L29/16 ,  A61L31/024 ,  A61L31/026 ,  A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61L2202/14 ,  A61L2300/10 ,  A61L2300/108 ,  A61L2300/404 ,  A61L2300/606 ,  A61M25/0045 ,  A61M27/006 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00

摘要： Systems, devices, methods, and compositions are described for providing an actively controllable implant configured to, for example, monitor, treat, or prevent microbial growth or adherence to the implant.

摘要翻译： 描述了用于提供被配置为例如监测，治疗或预防微生物生长或粘附于植入物的主动控制植入物的系统，装置，方法和组合物。

公开(公告)号：US09339588B2

公开(公告)日：2016-05-17

申请号：US14166217

申请日：2014-01-28

申请人： Bactiguard AB

发明人： Mattias Ohrlander ,  Billy Södervall

IPC分类号： A01N59/16 ,  A61L2/238 ,  A61L27/30 ,  B32B5/16 ,  B32B27/00 ,  C23C18/18 ,  A61L27/50 ,  A61L29/10 ,  A61L31/08 ,  A61L33/00 ,  C23C18/16 ,  C23C18/42 ,  C23C18/44 ,  C23C26/00 ,  C23C30/00 ,  A01N25/08 ,  A61K9/00 ,  A61K33/24 ,  A61K33/38 ,  B32B5/30 ,  B32B9/00 ,  B32B15/16 ,  B32B27/14 ,  B32B27/16 ,  A61L26/00 ,  B05D3/02

CPC分类号： A61L31/088 ,  A01N25/08 ,  A01N59/16 ,  A61K9/00 ,  A61K33/24 ,  A61K33/38 ,  A61L2/238 ,  A61L26/0004 ,  A61L27/30 ,  A61L27/306 ,  A61L27/50 ,  A61L29/10 ,  A61L29/106 ,  A61L31/022 ,  A61L31/024 ,  A61L31/026 ,  A61L31/042 ,  A61L31/048 ,  A61L31/06 ,  A61L31/08 ,  A61L33/0076 ,  A61L2400/18 ,  A61L2420/02 ,  B05D3/0254 ,  B32B5/16 ,  B32B5/30 ,  B32B9/005 ,  B32B15/16 ,  B32B27/00 ,  B32B27/14 ,  B32B27/16 ,  B32B2255/10 ,  B32B2255/205 ,  B32B2264/105 ,  B32B2307/7145 ,  B32B2307/73 ,  B32B2535/00 ,  C23C18/1635 ,  C23C18/1646 ,  C23C18/1689 ,  C23C18/18 ,  C23C18/42 ,  C23C18/44 ,  C23C26/00 ,  C23C30/00 ,  Y10T428/12569 ,  Y10T428/12875 ,  Y10T428/12896 ,  Y10T428/256 ,  Y10T428/27 ,  Y10T428/273 ,  Y10T428/29 ,  Y10T428/2991 ,  Y10T428/31667 ,  Y10T428/31678 ,  A01N25/10 ,  A01N25/34 ,  A01N2300/00

摘要： A substrate has an electron donating surface, and metal particles on its surface, the metal particles including palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of the metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.

摘要翻译： 基材具有给电子表面，其表面上的金属颗粒，金属颗粒包括钯和选自金，钌，铑，锇，铱和铂中的至少一种金属，其中金属的量 颗粒为约0.001至约8μg/ cm 2。 涂覆物体的实例包括隐形眼镜，起搏器，起搏器电极，支架，牙植入物，破裂网，破裂网，血液离心机设备，手术器械，手套，血袋，人造心脏瓣膜，中心静脉导管，外周静脉导管，血管端口 ，血液透析设备，腹膜透析设备，血浆置换装置，吸入药物递送装置，血管移植物，动脉移植物，心脏辅助装置，伤口敷料，间歇导管，ECG电极，外周支架，骨置换植入物，整形外科植入物，整形外科装置，组织替代 植入物，眼内透镜，缝线，针，药物输送装置，气管内导管，分流器，排水管，抽吸装置，助听器装置，尿道医疗装置和人造血管。