公开(公告)号：US06908926B1

公开(公告)日：2005-06-21

申请号：US09548081

申请日：2000-04-12

Applicant: Florencio Zaragoza Dörwald ,  Knud Erik Andersen ,  Tine Krogh Jørgensen ,  Bernd Peschke ,  Birgitte Schjellerup Wulff ,  Ingrid Pettersson ,  Klaus Rudolf ,  Dirk Stenkamp ,  Rudolf Hurnaus ,  Stephan Georg Müller ,  Bernd Krist

Inventor： Florencio Zaragoza Dörwald ,  Knud Erik Andersen ,  Tine Krogh Jørgensen ,  Bernd Peschke ,  Birgitte Schjellerup Wulff ,  Ingrid Pettersson ,  Klaus Rudolf ,  Dirk Stenkamp ,  Rudolf Hurnaus ,  Stephan Georg Müller ,  Bernd Krist

IPC: A61K31/437 ,  C07D235/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

CPC classification number: C07D235/06 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

Abstract: Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula I wherein R1, R2, R3, R4, R5, R6, A, X, Y and Z are as defined in the specification.

Abstract translation: 公开了一类新颖的取代的咪唑化合物，含有它们的药物组合物和这些化合物在治疗和/或预防与组胺H3受体相关的疾病和病症中的用途。 更具体地说，这些化合物可用于治疗和/或预防与组胺H3受体相互作用有益的疾病和病症。 这些咪唑化合物具有式I，其中R 1，R 2，R 3，R 4，R 4， SUP> 5，R 6，A，X，Y和Z如说明书中所定义。