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公开(公告)号：US06908926B1
公开(公告)日：2005-06-21
申请号：US09548081
申请日：2000-04-12
申请人： Florencio Zaragoza Dörwald , Knud Erik Andersen , Tine Krogh Jørgensen , Bernd Peschke , Birgitte Schjellerup Wulff , Ingrid Pettersson , Klaus Rudolf , Dirk Stenkamp , Rudolf Hurnaus , Stephan Georg Müller , Bernd Krist
发明人： Florencio Zaragoza Dörwald , Knud Erik Andersen , Tine Krogh Jørgensen , Bernd Peschke , Birgitte Schjellerup Wulff , Ingrid Pettersson , Klaus Rudolf , Dirk Stenkamp , Rudolf Hurnaus , Stephan Georg Müller , Bernd Krist
IPC分类号： A61K31/437 , C07D235/06 , C07D471/04 , C07D471/10 , C07D487/04
CPC分类号： C07D235/06 , C07D471/04 , C07D471/10 , C07D487/04
摘要： Disclosed is a novel class of substituted imidazole compounds, pharmaceutical compositions containing them and uses of these compounds in the treatment and/or prevention of diseases and disorders related to the histamine H3 receptor. More particularly, these compounds are useful for the treatment and/or prevention of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial. These imidazoles compounds have the formula I wherein R1, R2, R3, R4, R5, R6, A, X, Y and Z are as defined in the specification.
摘要翻译： 公开了一类新颖的取代的咪唑化合物，含有它们的药物组合物和这些化合物在治疗和/或预防与组胺H3受体相关的疾病和病症中的用途。 更具体地说，这些化合物可用于治疗和/或预防与组胺H3受体相互作用有益的疾病和病症。 这些咪唑化合物具有式I，其中R 1，R 2，R 3，R 4，R 4， SUP> 5，R 6，A，X，Y和Z如说明书中所定义。
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公开(公告)号：US20090149387A1
公开(公告)日：2009-06-11
申请号：US12370308
申请日：2009-02-12
申请人： Jens Juul Holst , Arne Vernon Astrup , Martin Edward Judge , Liselotte Bjerre Knudsen , Lars Thim , Birgitte Schjellerup Wulff
发明人： Jens Juul Holst , Arne Vernon Astrup , Martin Edward Judge , Liselotte Bjerre Knudsen , Lars Thim , Birgitte Schjellerup Wulff
IPC分类号： A61K38/16 , C07K14/605
CPC分类号： A61K38/26
摘要： GLP-1(1-45) or a fragment or an analogue thereof can be used in the preparation of a medicament for peripheral administration in the suppression of appetite or induction of satiety.
摘要翻译： GLP-1（1-45）或其片段或类似物可用于制备用于抑制食欲或诱导饱腹感的外周施用的药物。
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公开(公告)号：US20120021973A1
公开(公告)日：2012-01-26
申请号：US13130839
申请日：2009-11-24
IPC分类号： A61K38/12 , A61P3/04 , A61P3/10 , A61P25/00 , A61P15/00 , A61P3/06 , A61P9/00 , A61P1/16 , A61P19/02 , A61P35/00 , C07K7/56 , A61P9/10
CPC分类号： C07K14/685 , A61K47/542 , A61K47/545
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型，化合物在治疗中的用途的新型肽化合物，包括向有需要的患者施用化合物的方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。
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公开(公告)号：US07517854B2
公开(公告)日：2009-04-14
申请号：US11278014
申请日：2006-03-30
申请人： Kilian Waldemar Conde-Frieboes , Ulrich Sensfuss , Kjeld Madsen , Nils Langeland Johansen , Leif Christensen , Thomas Kruse Hansen , Birgitte Schjellerup Wulff
发明人： Kilian Waldemar Conde-Frieboes , Ulrich Sensfuss , Kjeld Madsen , Nils Langeland Johansen , Leif Christensen , Thomas Kruse Hansen , Birgitte Schjellerup Wulff
IPC分类号： A61K38/12
摘要： Small cyclic peptides of the formula X1-X2-X3-X4-X5-X6-X7-R1 comprising 7-12 amino acid residues are provided. Said peptides are MC4 receptor agonists, and thus useful in the treatment of obesity and related diseases.
摘要翻译： 提供了包含7-12个氨基酸残基的式X1-X2-X3-X4-X5-X6-X7-R1的小环肽。 所述肽是MC4受体激动剂，因此可用于治疗肥胖症和相关疾病。
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公开(公告)号：US20100173835A1
公开(公告)日：2010-07-08
申请号：US12626188
申请日：2009-11-25
CPC分类号： C07K14/685 , A61K47/542 , A61K47/545
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。
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6.发明申请公开(公告)号：US20100022446A1
公开(公告)日：2010-01-28
申请号：US12523197
申请日：2008-01-17
CPC分类号： A61K47/545 , A61K47/542 , A61K47/60 , A61K2300/00
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。
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公开(公告)号：US20130012432A1
公开(公告)日：2013-01-10
申请号：US13580042
申请日：2011-02-28
申请人： Kilian Waldemar Conde-Frieboes , Jane Spetzler , Ulrich Sensfuss , Birgitte Schjellerup Wulff , Henning Thoegersen , Jens Christian Norrild
发明人： Kilian Waldemar Conde-Frieboes , Jane Spetzler , Ulrich Sensfuss , Birgitte Schjellerup Wulff , Henning Thoegersen , Jens Christian Norrild
IPC分类号： A61K38/12 , A61P3/10 , A61P3/04 , A61P3/00 , A61P35/00 , A61P15/00 , A61P9/12 , A61P1/16 , A61P19/08 , A61P19/02 , A61P29/00 , A61P37/06 , C07K7/56 , A61P9/00
CPC分类号： C07K14/68
摘要： The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of obesity as well as a variety of diseases or conditions associated with obesity.
摘要翻译： 本发明涉及有效调节一种或多种黑皮质素受体类型的新型肽化合物，治疗中化合物的用途，包括向有需要的患者施用化合物的治疗方法，以及使用 药物制造中的化合物。 本发明的化合物在治疗肥胖以及与肥胖相关的各种疾病或病症方面特别有意义。
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公开(公告)号：US20110028391A1
公开(公告)日：2011-02-03
申请号：US12905324
申请日：2010-10-15
申请人： Jens Juul Holst , Arne Vernon Astrup , Martin Edward Judge , Liselotte Bjerre Knudsen , Lars Thim , Birgitte Schjellerup Wulff
发明人： Jens Juul Holst , Arne Vernon Astrup , Martin Edward Judge , Liselotte Bjerre Knudsen , Lars Thim , Birgitte Schjellerup Wulff
CPC分类号： A61K38/26
摘要： GLP-1(1-45) or a fragment or an analogue thereof can be used in the preparation of a medicament for peripheral administration in the suppression of appetite or induction of satiety.
摘要翻译： GLP-1（1-45）或其片段或类似物可用于制备用于抑制食欲或诱导饱腹感的外周施用的药物。
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公开(公告)号：US20100113363A1
公开(公告)日：2010-05-06
申请号：US12651685
申请日：2010-01-04
申请人： Jens Juul Holst , Arne Vernon Astrup , Martin Edward Judge , Liselotte Bjerre Knudsen , Lars Thim , Birgitte Schjellerup Wulff
发明人： Jens Juul Holst , Arne Vernon Astrup , Martin Edward Judge , Liselotte Bjerre Knudsen , Lars Thim , Birgitte Schjellerup Wulff
IPC分类号： A61K38/26 , C07K14/605 , A61P3/00 , A61P3/04
CPC分类号： A61K38/26
摘要： GLP-1(1-45) or a fragment or an analogue thereof can be used in the preparation of a medicament for peripheral administration in the suppression of appetite or induction of satiety.
摘要翻译： GLP-1（1-45）或其片段或类似物可用于制备用于抑制食欲或诱导饱腹感的外周施用的药物。
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10.发明授权
公开(公告)号：US5912229A
公开(公告)日：1999-06-15
申请号：US808825
申请日：1997-02-28
申请人： Lars Thim , Birgitte Schjellerup Wulff , Martin Edward Judge , Ole Dragsbaek Madsen , Jens Juul Holst
发明人： Lars Thim , Birgitte Schjellerup Wulff , Martin Edward Judge , Ole Dragsbaek Madsen , Jens Juul Holst
IPC分类号： A61K38/00 , C07K14/605 , A61K38/26
CPC分类号： C07K14/605 , A61K38/00
摘要： The present invention relates to appetite-suppressing peptides or an appetite-suppressing peptide-containing fraction for the treatment of obesity or type II diabetes.
摘要翻译： 本发明涉及食欲抑制肽或用于治疗肥胖或II型糖尿病的食欲抑制肽含量部分。
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