公开(公告)号：US20230220384A1

公开(公告)日：2023-07-13

申请号：US17766677

申请日：2020-10-06

Applicant: Prashant MONIAN ,  Chikdu Shakti SHIVAILA ,  Subramanian MARAPPAN ,  Chandra VARGEESE ,  Pachamuthu KANDASAMY ,  Genliang LU ,  Hui YU ,  David Charles Donnell BUTLER ,  Luciano Henrique APPONI ,  Mamoru SHIMIZU ,  Stephany Michelle STANDLEY ,  David John BOULAY ,  Andrew Guzior HOSS ,  Jigar DESAI ,  Jack David GODFREY ,  Hailin YANG ,  Naoki IWAMOTO ,  WAVE LIFE SCIENCES LTD.

Inventor： Prashant Monian ,  Chikdu Shakti Shivalila ,  Subramanian Marappan ,  Chandra Vargeese ,  Pachamuthu Kandasamy ,  Genliang Lu ,  Hui Yu ,  David Charles Donnell Butler ,  Luciano Henrique Apponi ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  David John Boulay ,  Andrew Guzior Hoss ,  Jigar Desai ,  Jack David Godfrey ,  Hailin Yang ,  Naoki Iwamoto

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2310/314 ,  C12N2310/322 ,  C12N2310/321 ,  C12N2310/315

Abstract: Among other things, the present disclosure provides oligonucleotides and compositions thereof. In some embodiments, provided oligonucleotides and compositions are useful for adenosine modification. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine modification.

公开(公告)号：US20200231620A1

公开(公告)日：2020-07-23

申请号：US16648146

申请日：2018-09-17

Applicant: Keith Andrew BOWMAN ,  Chandra VARGEESE ,  David Charles Donnell BUTLER ,  Pachamuthu KANDASAMY ,  Mohammed Rowshon ALAM ,  Mamoru SHIMIZU ,  Stephany Michelle STANDLEY ,  Vincent ADUDA ,  Gopal Reddy BOMMINENI ,  Snehlata TRIPATHI ,  Ilia KORBOUKH ,  WAVE LIFE SCIENCES LTD.

Inventor： Keith Andrew Bowman ,  Chandra Vargeese ,  David Charles Donnell Butler ,  Pachamuthu Kandasamy ,  Mohammed Rowshon Alam ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  Vincent Aduda ,  Gopal Reddy Bommineni ,  Snehlata Tripathi ,  Ilia Korboukh

IPC: C07H21/02 ,  C07H21/04

Abstract: Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

公开(公告)号：US20230089442A1

公开(公告)日：2023-03-23

申请号：US17439755

申请日：2020-03-19

Applicant: Pachamuthu KANDASAMY ,  Mamoru SHIMIZU ,  David Charles Donnell BUTLER ,  Jayakanthan KUMARASAMY ,  Gopal Reddy BOMMINENI ,  Mohammed Rowshon ALAM ,  Sethumadhavan DIVAKARAMENON ,  Bijay Tilak BHATTARAI ,  Chandra VARGEESE ,  Keith Andrew BOWMAN ,  Stephany Michelle STANDLEY ,  WAVE LIFE SCIENCES LTD.

Inventor： Pachamuthu Kandasamy ,  Mamoru Shimizu ,  David Charles Donnell Butler ,  Jayakanthan Kumarasamy ,  Gopal Reddy Bommineni ,  Mohammed Rowshon Alam ,  Sethumadhavan Divakaramenon ,  Bijay Tilak Bhattarai ,  Chandra Vargeese ,  Keith Andrew Bowman ,  Stephany Michelle Standley

IPC: C07H1/02 ,  C07H21/00 ,  C07H19/04

Abstract: Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.