公开(公告)号：US20130109735A1

公开(公告)日：2013-05-02

申请号：US13513142

申请日：2010-12-01

申请人： Brian Mario Pinto ,  Sankar Mohan ,  Ravindranath Nasi ,  Jayakanthan Kumarasamy ,  Razieh Eskarandi

发明人： Brian Mario Pinto ,  Sankar Mohan ,  Ravindranath Nasi ,  Jayakanthan Kumarasamy ,  Razieh Eskarandi

IPC分类号： C07D333/46 ,  C07D207/12 ,  C07D493/04 ,  C07D345/00

CPC分类号： C07D333/46 ,  C07D207/12 ,  C07D345/00 ,  C07D493/04 ,  C07H5/10 ,  C07H15/18

摘要： Salacinol and ponkoranol homologues, derivatives thereof and methods of synthesizing and using said homologies and derivatives. The derivatives include stereoisomers, de-O-sulfonated compounds and congeners of the naturally occurring homologues. Some of the derivatives exhibit enhanced glucosidase inhibitory bioactivity in comparison to the naturally occurring compounds which have been isolated from Salacia reticulata.

摘要翻译： salacinol和ponkoranol同源物，其衍生物和合成和使用所述同源物和衍生物的方法。 衍生物包括立体异构体，脱-O-磺化化合物和天然存在的同系物的同源物。 与从Salacia reticulata分离的天然存在的化合物相比，一些衍生物表现出增强的葡糖苷酶抑制生物活性。

公开(公告)号：US20230203087A1

公开(公告)日：2023-06-29

申请号：US17926987

申请日：2021-05-24

申请人： Pachamuthu Kandasamy ,  Jayakanthan Kumarasamy ,  Chandra Vargeese ,  Subramanian Marappan ,  Gopal Bommineni ,  Mamoru Shimizu ,  Naoki Iwamoto ,  Stephany Standley ,  Yuanjing Liu ,  Amy Jada Andreucci ,  Genliang LU ,  Onanong Chivatakarn ,  Akbar Husain Khan ,  WAVE LIFE SCIENCES LTD.

发明人： Pachamuthu Kandasamy ,  Jayakanthan Kumarasamy ,  Chandra Vargeese ,  Subramanian Marappan ,  Gopal Reddy Bommineni ,  Mamoru Shimizu ,  Naoki Iwamoto ,  Stephany Michelle Standley ,  Yuanjing Liu ,  Amy Jada Andreucci ,  Genliang Lu ,  Onanong Chivatakarn ,  Akbar Husain Khan

IPC分类号： C07H21/04 ,  C07F9/165 ,  C07D295/02

CPC分类号： C07H21/04 ,  C07F9/165 ,  C07D295/02

摘要： The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.

公开(公告)号：US20220306573A1

公开(公告)日：2022-09-29

申请号：US17046752

申请日：2019-04-11

申请人： Jason Jingxi ZHANG ,  Chandra VARGEESE ,  Naoki IWAMOTO ,  Chikdu Shakti SHIVALILA ,  Nayantara KOTHARI ,  Ann Fiegen DURBIN ,  Selvi RAMASAMY ,  Pachamuthu KANDASAMY ,  Jayakanthan KUMARASAMY ,  Gopal Reddy BOMMINENI ,  Subramanian MARAPPAN ,  Sethumadhavan DIVAKARAMENON ,  David Charles Donnel BUTLER ,  Genliang LU ,  Hailin YANG ,  Mamoru SHIMIZU ,  Prashant MONIAN ,  WAVE LIFE SCIENCES LTD.

发明人： Jason Jingxin Zhang ,  Chandra Vargeese ,  Naoki Iwamoto ,  Chikdu Shakti Shivalila ,  Nayantara Kothari ,  Ann Fiegen Durbin ,  Selvi Ramasamy ,  Pachamuthu Kandasamy ,  Jayakanthan Kumarasamy ,  Gopal Reddy Bommineni ,  Subramanian Marappan ,  Sethumadhavan Divakaramenon ,  David Charles Donnell Butler ,  Genliang Lu ,  Hailin Yang ,  Mamoru Shimizu ,  Prashant Monian

IPC分类号： C07C317/28 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113

摘要： Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods of use thereof. In some embodiments, the present disclosure provides technologies useful for reducing levels of transcripts. In some embodiments, the present disclosure provides technologies useful for modulating transcript splicing. In some embodiments, provided technologies can alter splicing of a dystrophin (DMD) transcript. In some embodiments, the present disclosure provides methods for treating diseases, such as Duchenne muscular dystrophy, Becker's muscular dystrophy, etc.

公开(公告)号：US20110268822A1

公开(公告)日：2011-11-03

申请号：US12934898

申请日：2009-03-25

申请人： Brian Mario Pinto ,  Jayakanthan Kumarasamy ,  Ravindranath Nasi ,  Sankar Mohan

发明人： Brian Mario Pinto ,  Jayakanthan Kumarasamy ,  Ravindranath Nasi ,  Sankar Mohan

IPC分类号： A61K36/00 ,  A61K31/40 ,  A61K31/381 ,  G01N27/447 ,  C07D207/00 ,  C07D333/46 ,  A61P1/00 ,  A61P3/10 ,  A61K31/33 ,  C07D345/00

CPC分类号： C07D207/12 ,  C07D319/06 ,  C07D327/10 ,  C07D333/46 ,  C07D345/00 ,  C07D407/04 ,  C07D407/06 ,  C07D411/04 ,  C07D493/04 ,  C07D497/04

摘要： Compounds having the general formula (I): wherein X is S, Se or NH, and stereoisomers thereof, and de-O-sulfonated analogues of all of the foregoing, but excluding naturally occurring kotalanol and de-O-sulfonated kotalanol, and methods for synthesizing same. The compounds are useful as glycosidase inhibitors, and may be used in the treatment of diabetes. The synthetic compounds may also be used as standards in the calibration or grading of natural or herbal remedies produced from natural sources of glycosidase inhibitors such as kotalanol.

摘要翻译： 具有通式（I）的化合物：其中X是S，Se或NH及其立体异构体，以及所有上述的脱-O-磺化类似物，但不包括天然存在的kotalanol和de-O-磺化的kotalanol，以及方法 用于合成。 该化合物可用作糖苷酶抑制剂，可用于治疗糖尿病。 合成的化合物也可以用作由天然来源的糖苷酶抑制剂如kotalanol产生的天然或草药的校准或分级的标准品。

公开(公告)号：US20230089442A1

公开(公告)日：2023-03-23

申请号：US17439755

申请日：2020-03-19

申请人： Pachamuthu KANDASAMY ,  Mamoru SHIMIZU ,  David Charles Donnell BUTLER ,  Jayakanthan KUMARASAMY ,  Gopal Reddy BOMMINENI ,  Mohammed Rowshon ALAM ,  Sethumadhavan DIVAKARAMENON ,  Bijay Tilak BHATTARAI ,  Chandra VARGEESE ,  Keith Andrew BOWMAN ,  Stephany Michelle STANDLEY ,  WAVE LIFE SCIENCES LTD.

发明人： Pachamuthu Kandasamy ,  Mamoru Shimizu ,  David Charles Donnell Butler ,  Jayakanthan Kumarasamy ,  Gopal Reddy Bommineni ,  Mohammed Rowshon Alam ,  Sethumadhavan Divakaramenon ,  Bijay Tilak Bhattarai ,  Chandra Vargeese ,  Keith Andrew Bowman ,  Stephany Michelle Standley

IPC分类号： C07H1/02 ,  C07H21/00 ,  C07H19/04

摘要： Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.