公开(公告)号：US5769792A

公开(公告)日：1998-06-23

申请号：US632018

申请日：1996-04-15

申请人： Branko Palcic ,  Calum E. MacAulay ,  Bruno W. Jaggi ,  Stephen C-T Lam ,  Amedeus E. Profio ,  Jaclyn Y-C Hung

发明人： Branko Palcic ,  Calum E. MacAulay ,  Bruno W. Jaggi ,  Stephen C-T Lam ,  Amedeus E. Profio ,  Jaclyn Y-C Hung

IPC分类号： A61B5/00 ,  A61B6/00

CPC分类号： A61B5/0084 ,  A61B5/0071 ,  G01N2021/6463

摘要： Apparatus for imaging diseases in tissue comprising a light source for generating excitation light that includes wavelengths capable of generating characteristic autofluorescence for abnormal and normal tissue. A fiber-optic illuminating light guide is used to illuminate tissue with light that includes at least the excitation light thereby exciting the tissue to emit the characteristic autofluorescence. An imaging bundle collects emitted autofluorescence light from the tissue. The autofluorescence light is filtered into spectral bands in which the autofluorescence intensity for abnormal tissue is substantially different from normal tissue and the autofluorescence intensity for abnormal tissue is substantially similar to normal tissue. An optical system is used to intercept the filtered autofluorescence light to acquire at least two filtered emitted autofluorescence images of the tissue. The acquired images are displayed in real time on a display monitor in such a manner as to delineate abnormal and normal tissue.

摘要翻译： 用于在组织中成像疾病的装置，包括用于产生激发光的光源，所述激发光包括能够产生用于异常和正常组织的特征性自发荧光的波长。 光纤照明光导用于用至少包含激发光的光照射组织，从而激发组织以发出特征自发荧光。 成像束从组织中收集发射的自发荧光。 自发荧光被过滤到光谱带，其中异常组织的自发荧光强度与正常组织基本不同，异常组织的自发荧光强度基本上与正常组织相似。 光学系统用于截取滤波的自发荧光以获得组织的至少两个经滤波的发射的自发荧光图像。 所获取的图像以描绘异常和正常组织的方式在显示监视器上实时显示。