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公开(公告)号：US20240361244A1
公开(公告)日：2024-10-31
申请号：US18766095
申请日：2024-07-08
发明人： Tomonori NAKAMURA
CPC分类号： G01N21/6456 , G01N21/62 , G01N21/63 , G01N21/64 , G01N21/6458 , G01N21/6489 , G01N21/8806 , G01N21/8851 , G01N21/9501 , G01N21/9505 , G01N2021/0112 , G01N2021/6421 , G01N2021/6463 , G01N2021/6484 , G01N2021/8845
摘要： An inspection apparatus is an inspection apparatus for inspecting a sample on which a plurality of light-emitting elements is formed, and includes an excitation light source that generates excitation light to irradiate the sample, a camera that images fluorescence having a wavelength longer than a reference wavelength in fluorescence from the light-emitting elements, and a control apparatus that determines a quality of each of the light-emitting elements based on fluorescence imaged by the camera, in which the reference wavelength is a wavelength obtained by adding a full width at half maximum of a normal fluorescence spectrum of the light-emitting element to a peak wavelength of the normal fluorescence spectrum.
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公开(公告)号：US20240309441A1
公开(公告)日：2024-09-19
申请号：US18583747
申请日：2024-02-21
发明人： Mingsong Chen , Soo Yong Lau , Kuan Moon Boo , Mauro Aguanno , Huei Yeo , Tiong Han Toh , Wei Fuh Teo
CPC分类号： C12Q1/686 , B01L7/52 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N21/6458 , G02B21/244 , B01L2200/10 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/18 , G01N2021/6463
摘要： An instrument for biological analysis includes a base, an excitation source, an optical sensor, an excitation optical system, and an emission optical system. The base is configured to receive a sample holder comprising a plurality of biological samples. The optical sensor is configured to receive emissions from the biological samples in response to the excitation source. The instrument may additionally include a sensor lens enclosed by a lens case and a focusing mechanism including a gear that engages the lens case, the focusing mechanism being accessible outside the enclosure for adjusting a focus. The instrument may further include a sensor aperture dispose along an emission optical path and a blocking structure disposed to cooperate with the sensor aperture such that none of the reflected radiation from an illuminated surface near the sample holder is received by the optical sensor that does not also reflect off another surface of the instrument.
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公开(公告)号：US12031899B2
公开(公告)日：2024-07-09
申请号：US17102388
申请日：2020-11-23
申请人： IMEC VZW
发明人： Dries Vercruysse
IPC分类号： G01N15/1434 , F21V8/00 , G01N15/14 , G01N21/64 , G01N21/65 , G02B6/124 , G02B6/30 , G01N15/10 , G01N21/03
CPC分类号： G01N15/1436 , G01N15/1434 , G01N15/1484 , G01N21/6428 , G01N21/645 , G01N21/65 , G02B6/0036 , G02B6/124 , G02B6/30 , G01N2015/1006 , G01N2021/0346 , G01N2021/6463 , G01N2021/6482
摘要： A radiation carrier for carrying at least a radiation beam has, on a surface thereof, at least one excitation grating, for directing at least an excitation radiation beam directionally out of the radiation carrier, thereby illuminating a region of interest; and at least one structure for redirecting emission radiation emanating from the region of interest. Further a sensor is provided comprising at least one such radiation carrier and at least one detector, the structure being adapted for redirecting radiation from the region of interest into the at least one detector.
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公开(公告)号：US11982620B2
公开(公告)日：2024-05-14
申请号：US17441258
申请日：2020-03-17
发明人： Shaohong Wang
CPC分类号： G01N21/645 , G01N21/33 , G01N2021/174 , G01N2021/6463
摘要： An optical detection system for a capillary electrophoresis instrument is disclosed. The system includes an ultraviolet (UV) source and an absorption measurement optical path. In an embodiment, the optical path comprises a first plurality of optical elements arranged to obtain a plurality of respective UV beamlets from a UV beam emitted by the UV source and to direct the respective UV beamlets transversely through respective capillaries of a plurality of capillaries and to an absorption detector positioned to detect respective signals for use in obtaining respective UV absorption measurements corresponding to the respective capillaries.
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公开(公告)号：US20240085395A1
公开(公告)日：2024-03-14
申请号：US18512692
申请日：2023-11-17
发明人： Zhenwei Wang
CPC分类号： G01N33/1826 , G01J3/021 , G01J3/0218 , G01J3/0243 , G01J3/10 , G01J3/4406 , G01N21/6408 , G01N21/645 , G01N21/6402 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6463 , G01N2021/6484 , G01N2201/062
摘要： A water quality detection system including a light source, a spectrometer, and a data processor is disclosed, and relates to the technical field of detection systems. The light source emits excitation light pulse trains of different wavelengths to a to-be-detected water sample contained in a sample cell, where the excitation light pulse trains of different wavelengths may be emitted in a time-division manner, to excite the to-be-detected water sample, thereby generating fluorescence separately corresponding to the excitation light pulse trains of different wavelengths. The spectrometer receives the fluorescence and output a fluorescence spectrum based on the fluorescence. The data processor obtains, based on the fluorescence spectrum output by the spectrometer, a three-dimensional fluorescence spectrum including an excitation wavelength, a fluorescence wavelength, and a fluorescence intensity, identifies the to-be-detected water sample and obtains a parameter of the to-be-detected water sample based on the three-dimensional fluorescence spectrum.
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公开(公告)号：US20240003811A1
公开(公告)日：2024-01-04
申请号：US18335458
申请日：2023-06-15
发明人： Gerard Schmid , Dajiang Yang , Eric A.G. Webster , Xin Wang , Todd Rearick , Changhoon Choi , Ali Kabiri , Kyle Preston , Brian Reed
IPC分类号： G01N21/64 , H01L27/146
CPC分类号： G01N21/6454 , G01N21/6428 , H01L27/14603 , G01N21/6408 , G01N2021/6463
摘要： Some aspects relate to an integrated circuit, comprising at least one photodetection region configured to generate charge carriers responsive to incident photons emitted from a sample, at least one charge storage region configured to receive the charge carriers from the photodetection region, and at least one controller configured to obtain information about the incident photons, the information comprising at least one member selected from the group comprising pulse duration and interpulse duration and at least one member selected from the group comprising wavelength information, luminescence lifetime information, and intensity information. In some embodiments, the information comprises at least three, four, and/or five members selected from the group comprising wavelength information, luminescence lifetime information, intensity information, pulse duration information, and interpulse duration information. In some embodiments, the information obtained may be used to identify the sample.
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公开(公告)号：US11795504B2
公开(公告)日：2023-10-24
申请号：US17574416
申请日：2022-01-12
IPC分类号： C12Q1/6869 , G01N21/64 , G01N15/14 , C12N15/10 , C12Q1/6806
CPC分类号： C12Q1/6869 , C12N15/1006 , C12Q1/6806 , G01N15/147 , G01N15/1436 , G01N15/1484 , G01N21/6402 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N21/6486 , G01N2015/144 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2201/0612
摘要： Fluorescence imaging system designs are described that provide larger fields-of-view, increased spatial resolution, improved modulation transfer and image quality, higher spatial sampling frequency, faster transitions between image capture when repositioning the sample plane to capture a series of images (e.g., of different fields-of-view), and improved imaging system duty cycle, and thus enable higher throughput image acquisition and analysis for genomics and other imaging applications.
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公开(公告)号：US11789250B2
公开(公告)日：2023-10-17
申请号：US17087754
申请日：2020-11-03
发明人： Andreas Waag , Daria Bezshlyakh , Hendrik Spende , Jan Gülink
CPC分类号： G02B21/365 , G01N21/6458 , G02B21/16 , G02B27/30 , G01N2021/6463
摘要： An optical detection device having a light detection device and a light emission device is arranged such that the light detection side of the light detection device is optically coupled to a light emission side of a light source array of the light emission device via an examination region. The light detection device generates an electrical signal n response to light that reaches the light detection side. The light source array includes a plurality of separately actuatable electric light sources which are arranged in a matrix structure or two dimensional geometric arrangement. The object to be examined can be arranged in a desired fashion, and the light emitted by the light sources radiates via the examination region on the light detection side of the light detection device. An optical reduction is system is arranged in the beam path from the light emission side to the examination region and is configured to demagnify the light pattern which is emitted by the light sources. Thus, the examination region is irradiated by a light pattern that has been demagnified with respect to the light pattern emitted.
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公开(公告)号：US11733205B2
公开(公告)日：2023-08-22
申请号：US17253805
申请日：2018-06-22
发明人： Satoshi Takahashi , Ryoji Inaba , Takashi Anazawa , Tomoyuki Sakai , Yusuke Goto
IPC分类号： G01N27/453 , G01N27/447 , G01N30/74 , G01N21/64
CPC分类号： G01N27/44756 , G01N27/44721 , G01N30/74 , G01N2021/6463
摘要： The present invention aims to provide an electrophoresis apparatus which makes it possible to execute protein analysis with a high throughput. The electrophoresis apparatus according to the present invention is equipped with a capillary array which is configured by arraying a plurality of capillaries, a measurement light irradiation unit which irradiates with measurement light, a first lens array which includes a plurality of first lenses which are arrayed in correspondence with the plurality of capillaries, a second lens array which includes a plurality of second lenses which are arrayed in correspondence with the plurality of capillaries, and a light receiving unit which receives light which is incident upon the capillaries via the first lens array from the measurement light irradiation unit via the second lens array.
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公开(公告)号：US20230160827A1
公开(公告)日：2023-05-25
申请号：US18158211
申请日：2023-01-23
发明人： Vincent Studer , Rémi Galland
CPC分类号： G01N21/6458 , G02B21/02 , G02B21/16 , G02B21/36 , G02B26/0833 , G02B27/141 , G01N2021/6463
摘要： Optical device for optical fluorescence microscopy, comprising a spatial modulator (1), a microscope objective (2), a beamsplitter (3) and a camera (4), wherein the beamsplitter (3) is placed between the spatial modulator (1) and the microscope objective (2), wherein the beamsplitter (3) is placed between the camera (4) and the microscope objective (2), and wherein a prism (5) is placed between the beamsplitter (3) and the camera (4).
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