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公开(公告)号：US06514517B2
公开(公告)日：2003-02-04
申请号：US09885714
申请日：2001-06-20
IPC分类号： A61F202
CPC分类号： A61L31/16 , A61L2/16 , A61L17/005 , A61L17/145 , A61L31/08 , A61L31/10 , A61L2300/21 , A61L2300/404 , A61L2300/606 , C08L67/00
摘要： The present invention is directed to compositions containing an acid precursor in amounts effective to inhibit microbial attachment and growth on a surface of a medical device having the composition applied thereto, to films of such compositions and to medical devices having the composition applied to a surface thereof.
摘要翻译： 本发明涉及含有有效抑制微生物附着和生长的组合物的组合物的组合物的组合物，该组合物具有施用组合物的组合物的薄膜，以及具有应用于其表面的组合物的医疗装置 。
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公开(公告)号：US6121302A
公开(公告)日：2000-09-19
申请号：US309686
申请日：1999-05-11
CPC分类号： A61K47/22 , A61K31/425
摘要： The present invention provides a highly stable formulation having broad spectrum preservative properties. The formulation is an admixture of dialkanol-substituted dimethyhydantoin, one or more isothiazolone compounds, a hydantoin stabilizer, and a hydroxyl solvent. The formulation is highly stable in pH ranges of about 4 to 8. Preferably the active components are dimethyloldimethylhydantoin, chloromethylisothiazolone and methylisothiazolone, and the stabilizer dimethylhydantoin. The formulation has a free formaldehyde content of less than 0.2% and is beneficial for preserving various aqueous compositions, including household and industrial products, and especially personal care products, which require a less acidic pH range than in which isothiazolone is stable in the presence of cationic salts.
摘要翻译： 本发明提供具有广谱防腐性质的高度稳定的制剂。 制剂是二烷醇取代的二乙基乙内酰脲，一种或多种异噻唑酮化合物，乙内酰脲稳定剂和羟基溶剂的混合物。 该制剂在约4至8的pH范围内高度稳定。优选活性组分是二羟甲基二乙醇鲸脑油，氯甲基异噻唑酮和甲基异噻唑酮，稳定剂二甲基乙内酰脲。 该制剂的游离甲醛含量小于0.2％，有利于保存各种含水组合物，包括家用和工业产品，特别是个人护理产品，其需要的酸性pH范围小于在异噻唑酮在 阳离子盐。
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