公开(公告)号：US20100267981A1

公开(公告)日：2010-10-21

申请号：US12629753

申请日：2009-12-02

申请人： Stephen J. Baker ,  Tsutomu Akama ,  Michael Richard Kevin Alley ,  Steven J. Benkovic ,  Michael DiPierro ,  Vincent S. Hernandez ,  Karin M. Hold ,  Isaac Kennedy ,  Igor Likhotvorik ,  Weimin Mao ,  Kirk R. Maples ,  Jacob J. Plattner ,  Fernando Rock ,  Virginia Sanders ,  Aaron M. Stemphoski ,  George Petros Yiannikouros ,  Siead Zegar ,  Yong-Kang Zhang ,  Huchen Zhou

发明人： Stephen J. Baker ,  Tsutomu Akama ,  Michael Richard Kevin Alley ,  Steven J. Benkovic ,  Michael DiPierro ,  Vincent S. Hernandez ,  Karin M. Hold ,  Isaac Kennedy ,  Igor Likhotvorik ,  Weimin Mao ,  Kirk R. Maples ,  Jacob J. Plattner ,  Fernando Rock ,  Virginia Sanders ,  Aaron M. Stemphoski ,  George Petros Yiannikouros ,  Siead Zegar ,  Yong-Kang Zhang ,  Huchen Zhou

IPC分类号： C07F5/02

CPC分类号： C07F5/025 ,  A61K9/0012 ,  A61K9/08 ,  A61K31/69 ,  A61K31/70 ,  A61K31/7076 ,  A61K47/10 ,  C07F5/04 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00 ,  C07H23/00 ,  Y02A50/473

摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。

公开(公告)号：US08115026B2

公开(公告)日：2012-02-14

申请号：US12629753

申请日：2009-12-02

申请人： Stephen J. Baker ,  Tsutomu Akama ,  Michael Richard Kevin Alley ,  Steven J. Benkovic ,  Michael DiPierro ,  Vincent S. Hernandez ,  Karin M. Hold ,  Isaac Kennedy ,  Igor Likhotvorik ,  Weimin Mao ,  Kirk R. Maples ,  Jacob J. Plattner ,  Fernando Rock ,  Virginia Sanders ,  Aaron M. Stemphoski ,  George Petros Yiannikouros ,  Siead Zegar ,  Yong-Kang Zhang ,  Huchen Zhou

发明人： Stephen J. Baker ,  Tsutomu Akama ,  Michael Richard Kevin Alley ,  Steven J. Benkovic ,  Michael DiPierro ,  Vincent S. Hernandez ,  Karin M. Hold ,  Isaac Kennedy ,  Igor Likhotvorik ,  Weimin Mao ,  Kirk R. Maples ,  Jacob J. Plattner ,  Fernando Rock ,  Virginia Sanders ,  Aaron M. Stemphoski ,  George Petros Yiannikouros ,  Siead Zegar ,  Yong-Kang Zhang ,  Huchen Zhou

IPC分类号： C07F5/04

CPC分类号： C07F5/025 ,  A61K9/0012 ,  A61K9/08 ,  A61K31/69 ,  A61K31/70 ,  A61K31/7076 ,  A61K47/10 ,  C07F5/04 ,  C07H19/06 ,  C07H19/16 ,  C07H21/00 ,  C07H23/00 ,  Y02A50/473

摘要： This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.

摘要翻译： 本发明涉及可用于治疗真菌感染的化合物，更具体地涉及甲真菌病和/或皮肤真菌感染的局部治疗。 本发明涉及对真菌具有活性的化合物，并具有允许化合物与患者接触时达到感染真菌的皮肤，指甲，毛发，爪或蹄特定部位的性质。 特别地，本发明化合物具有促进钉板穿透的物理化学性质。