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公开(公告)号：US20100087502A1
公开(公告)日：2010-04-08
申请号：US12529561
申请日：2008-03-05
申请人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
发明人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
IPC分类号： A61K31/416 , C07D231/56 , A61P9/00 , A61P25/00 , A61P29/00 , A61P37/00 , A61P3/00
CPC分类号： C07D231/56
摘要： The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译： 本发明涉及具有药理学活性的新的吲唑衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。
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公开(公告)号：US07960563B2
公开(公告)日：2011-06-14
申请号：US12529561
申请日：2008-03-05
申请人： Christopher Norbert Johnson , David G Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
发明人： Christopher Norbert Johnson , David G Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Antoinette Naylor , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani
IPC分类号： C07D231/56 , A61K31/416
CPC分类号： C07D231/56
摘要： The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译： 本发明涉及具有药理学活性的新的吲唑衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。
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公开(公告)号：US20090054456A1
公开(公告)日：2009-02-26
申请号：US11996650
申请日：2006-07-24
申请人： Christopher Norbert Johnson , David Timothy Macpherson , Steven James Stanway , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
发明人： Christopher Norbert Johnson , David Timothy Macpherson , Steven James Stanway , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC分类号： A61K31/496 , C07D401/08 , C07D401/14
CPC分类号： C07D401/10 , C07D401/14
摘要： The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
摘要翻译： 本发明涉及新型苄基哌嗪衍生物，例如具有作为GPR38受体激动剂的活性的式（I）化合物，以及这些化合物或其药物组合物在治疗胃肠道疾病中的用途。
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公开(公告)号：US08536182B2
公开(公告)日：2013-09-17
申请号：US11996650
申请日：2006-07-24
申请人： Christopher Norbert Johnson , David Timothy Macpherson , Steven James Stanway , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
发明人： Christopher Norbert Johnson , David Timothy Macpherson , Steven James Stanway , Geoffrey Stemp , Mervyn Thompson , Susan Marie Westaway
IPC分类号： A61K31/497 , A61K31/44 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D421/00
CPC分类号： C07D401/10 , C07D401/14
摘要： The present invention relates to novel benzylpiperazine derivatives such as compounds of formula (I), which have activity as agonists of the GPR38 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of gastrointestinal disorders.
摘要翻译： 本发明涉及新型苄基哌嗪衍生物，例如具有作为GPR38受体激动剂的活性的式（I）化合物，以及这些化合物或其药物组合物在治疗胃肠道疾病中的用途。
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公开(公告)号：US07956083B2
公开(公告)日：2011-06-07
申请号：US12864933
申请日：2009-02-17
申请人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
发明人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
IPC分类号： A01N43/38 , C07D209/04
CPC分类号： C07D209/08
摘要： The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译： 本发明涉及具有药理活性的新型吲哚衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。
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6.发明授权Hydroxamic acid derivatives as inhibitors of the production of human CD23 and of the TNF release 失效羟肟酸衍生物作为人CD23的产生抑制剂和TNF释放公开(公告)号：US06458779B1
公开(公告)日：2002-10-01
申请号：US09701946
申请日：2001-04-05
申请人： Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Jayshree Mistry , John Gerald Ward
发明人： Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Jayshree Mistry , John Gerald Ward
IPC分类号： A61K31545
CPC分类号： C07D207/404 , C07C237/22 , C07C259/06 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07C2602/10 , C07D215/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D271/06 , C07D277/24 , C07D311/58 , C07D333/54 , C07D333/60
摘要： Compounds of Formula (1) wherein: R is methyl substituted by one to three groups from alkyl, aryl, alkenyl, and alkynyl; n is ) or 1; R1 is arylmethyl or heterocyclylmethyl; R2 is alkyl, alkenyl, cycloalkyl or cycloalkenyl; and R3 is hydrogen, alkyl, alkenyl, alkynyl or aryl; are useful in the treatment of disorders mediated y s-CD23.
摘要翻译： 式（1）的化合物，其中：R是被烷基，芳基，烯基和炔基一至三个基团取代的甲基; n是）或1; R1是芳基甲基或杂环基甲基; R2是烷基，烯基，环烷基或环烯基; R3是氢，烷基，烯基，炔基或芳基; 可用于治疗介导的s-CD23的病症。
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公开(公告)号：US6147111A
公开(公告)日：2000-11-14
申请号：US227670
申请日：1999-01-08
IPC分类号： C07D317/14 , A61K31/357 , A61K31/36 , A61K31/41 , A61P1/16 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P43/00 , C07D317/60 , C07D317/64 , C07D405/12 , A61K31/216 , A61P21/02 , C07C69/76
CPC分类号： C07D317/60 , C07D317/64
摘要： Novel phenyl derivatives which are useful as endothelin receptor antagonists.
摘要翻译： 可用作内皮素受体拮抗剂的新型苯基衍生物。
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公开(公告)号：US20100324106A1
公开(公告)日：2010-12-23
申请号：US12864933
申请日：2009-02-17
申请人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
发明人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy Macpherson , Aaron B. Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
IPC分类号： A61K31/404 , C07D209/12 , A61P9/00 , A61P29/00 , A61P35/00 , A61P25/00 , A61P3/00 , A61P3/04
CPC分类号： C07D209/08
摘要： The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译： 本发明涉及具有药理活性的新型吲哚衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。
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公开(公告)号：US07253198B2
公开(公告)日：2007-08-07
申请号：US10536303
申请日：2003-12-03
申请人： Emmanuel H Demont , Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Alan Naylor , Sally Redshaw , Steven James Stanway , David R Vesey , Daryl S Walter
发明人： Emmanuel H Demont , Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Alan Naylor , Sally Redshaw , Steven James Stanway , David R Vesey , Daryl S Walter
IPC分类号： C07D275/03 , C07D207/12 , A61K31/425 , A61K31/4015
CPC分类号： C07D207/267 , C07D211/76 , C07D275/02 , C07D279/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel hydroxyethylamine compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
摘要翻译： 本发明涉及具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性的新型羟乙基胺化合物，其制备方法，含有它们的组合物及其用于治疗以β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。
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10.发明授权Benzamide derivatives, processes for their preparation, and their pharmaceutical use 失效苯甲酰胺衍生物，其制备方法及其药物用途公开(公告)号：US06992103B2
公开(公告)日：2006-01-31
申请号：US10496269
申请日：2002-11-29
申请人： Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Steven James Stanway , Leontine Saskia Trouw
发明人： Andrew Faller , David Timothy MacPherson , Peter Henry Milner , Steven James Stanway , Leontine Saskia Trouw
IPC分类号： A61K31/4015 , A61K31/4166 , A61K31/4439 , C07D207/24 , C07D223/10
CPC分类号： C07D207/267 , C07D211/76 , C07D223/10 , C07D263/22
摘要： The present invention relates to novel hydroxyethylene compounds having Asp2 (β-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.
摘要翻译： 本发明涉及具有Asp2（β-分泌酶，BACE1或Memapsin）抑制活性的新型羟基亚乙基化合物，其制备方法，含有它们的组合物及其用于治疗以β-淀粉样蛋白升高或β- 淀粉样沉积物，特别是阿尔茨海默氏病。
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