公开(公告)号：US20050106572A1

公开(公告)日：2005-05-19

申请号：US10712739

申请日：2003-11-13

申请人： Petar Dvornic ,  Steven Kaganove ,  Abhijit Sarkar

发明人： Petar Dvornic ,  Steven Kaganove ,  Abhijit Sarkar

IPC分类号： C07H21/00 ,  C12Q1/68

CPC分类号： C07H21/00 ,  Y10S436/805

摘要： Solid-state colorimetric biosensors having sensory groups and interdendritic cross-linking segments of alternating conjugated double and triple bonds are prepared by intermolecular polymerization of diacetylene-functionalized dendritic polymer precursors. The polymerization process may be used to form solid films that are capable of indicating the presence of an analyte by a detectable change in color. The disclosed solid-state calorimetric biosensors may exhibit excellent stability at elevated temperatures and in the presence of organic solvents, and due to the dendritic architecture and high density of sensing functionality achieve high sensitivity to analytes.

摘要翻译： 具有交联共轭双键和三键的感官基团和枝晶间交联链段的固态比色生物传感器通过二乙炔官能化的树枝状聚合物前体的分子间聚合制备。 聚合方法可以用于形成固体膜，其能够通过可检测的颜色变化来指示分析物的存在。 所公开的固态量热生物传感器在升高的温度和有机溶剂的存在下可表现出优异的稳定性，并且由于树突状结构和高密度的感测功能对分析物的高灵敏度。

公开(公告)号：US20060147414A1

公开(公告)日：2006-07-06

申请号：US11324826

申请日：2006-01-04

申请人： Steven Kaganove ,  Paul Satoh ,  Petar Dvornic

发明人： Steven Kaganove ,  Paul Satoh ,  Petar Dvornic

IPC分类号： A61K31/74 ,  A61K31/785

CPC分类号： A61K31/74 ,  A61K31/785

摘要： An improved synthetic blood substitute which exhibits excellent long-term storage stability at both high and low temperatures is suitable for use in various biomedical and biotechnical applications, including resuscitation of trauma victims that have suffered massive hemorrhaging, and transfusions for human and veterinary surgical procedures. The artificial blood solution comprises an aqueous carrier, and a dendritic polymer that is capable of carrying oxygen dissolved in the aqueous carrier. The dendritic polymer comprises fluorocarbon moieties and hydrophilic moieties.

摘要翻译： 在高温和低温下表现出优异的长期储存稳定性的改进的合成血液替代物适用于各种生物医学和生物技术应用，包括复苏大量出血的创伤受害者，以及用于人类和兽医外科手术的输血。 人造血液溶液包含水性载体和能够携带溶解在水性载体中的氧的树枝状聚合物。 树枝状聚合物包含氟碳部分和亲水部分。