公开(公告)号：US20080286333A1

公开(公告)日：2008-11-20

申请号：US11803433

申请日：2007-05-15

申请人： Steven Kangas ,  Jan Seppala ,  Peter G. Edelman

发明人： Steven Kangas ,  Jan Seppala ,  Peter G. Edelman

IPC分类号： A61F2/01 ,  A61L31/02 ,  A61L31/08 ,  A61L31/16 ,  C08L23/00 ,  C08L31/00 ,  C08L33/00

CPC分类号： A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/00 ,  A61N1/375

摘要： According to an aspect of the present invention, a medical device is provided which comprises a metallic substrate and polymeric region disposed over and in contact with the metallic substrate. The polymeric region comprises (a) a block copolymer that comprises (i) a hard polymer block that comprises a high Tg monomer and (ii) a soft polymer block that comprises a low Tg monomer, (b) an adhesion promoting copolymer that comprises (i) a first monomer that covalently or non-covalently bonds with the metallic substrate and (ii) a second monomer that is compatible with the low Tg monomer and/or the high Tg monomer and (c) a therapeutic agent. The polymeric region may further comprise an optional polymer that is used to tailor the release rate of the therapeutic agent.

摘要翻译： 根据本发明的一个方面，提供一种医疗装置，其包括金属基底和设置在金属基底上并与金属基底接触的聚合物区域。 聚合物区域包括（a）嵌段共聚物，其包含（i）包含高Tg单体的硬聚合物嵌段和（ii）包含低Tg单体的软聚合物嵌段，（b）粘合促进共聚物，其包含（ i）与金属基底共价或非共价键合的第一单体和（ii）与低Tg单体和/或高Tg单体相容的第二单体和（c）治疗剂。 聚合物区域还可以包含任选的聚合物，其用于定制治疗剂的释放速率。

公开(公告)号：US08168213B2

公开(公告)日：2012-05-01

申请号：US11803433

申请日：2007-05-15

申请人： Steven Kangas ,  Jan Seppala ,  Peter G. Edelman

发明人： Steven Kangas ,  Jan Seppala ,  Peter G. Edelman

IPC分类号： A61F2/02

CPC分类号： A61L31/10 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/16 ,  A61L2300/00 ,  A61N1/375

摘要： According to an aspect of the present invention, a medical device is provided which comprises a metallic substrate and polymeric region disposed over and in contact with the metallic substrate. The polymeric region comprises (a) a block copolymer that comprises (i) a hard polymer block that comprises a high Tg monomer and (ii) a soft polymer block that comprises a low Tg monomer, (b) an adhesion promoting copolymer that comprises (i) a first monomer that covalently or non-covalently bonds with the metallic substrate and (ii) a second monomer that is compatible with the low Tg monomer and/or the high Tg monomer and (c) a therapeutic agent. The polymeric region may further comprise an optional polymer that is used to tailor the release rate of the therapeutic agent.

摘要翻译： 根据本发明的一个方面，提供一种医疗装置，其包括金属基底和设置在金属基底上并与金属基底接触的聚合物区域。 聚合物区域包括（a）嵌段共聚物，其包含（i）包含高Tg单体的硬聚合物嵌段和（ii）包含低Tg单体的软聚合物嵌段，（b）粘合促进共聚物，其包含（ i）与金属基底共价或非共价键合的第一单体和（ii）与低Tg单体和/或高Tg单体相容的第二单体和（c）治疗剂。 聚合物区域还可以包含任选的聚合物，其用于定制治疗剂的释放速率。