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    Pharmaceutical formulations and systems for improved absorption and multistage release of active agents
    3.
    发明授权
    Pharmaceutical formulations and systems for improved absorption and multistage release of active agents 失效
    用于改善活性剂的吸收和多级释放的药物制剂和系统

    公开(公告)号：US07374779B2

    公开(公告)日：2008-05-20

    申请号：US10074687

    申请日：2002-02-11

    申请人： Feng-Jing Chen ,  Srinivasan Venkateshwaran ,  Steven L. Krill ,  Mahesh V. Patel

    发明人： Feng-Jing Chen ,  Srinivasan Venkateshwaran ,  Steven L. Krill ,  Mahesh V. Patel

    IPC分类号： A61K9/48 ,  A61K9/40 ,  A61K9/14 ,  A61K9/66 ,  A61K9/52

    CPC分类号： B82Y5/00 ,  A61K9/1617 ,  A61K9/4808 ,  A61K9/4858 ,  A61K9/5015 ,  A61K9/5026 ,  A61K9/5084 ,  A61K31/57 ,  A61K38/13

    摘要： The present invention pertains to pharmaceutical formulations and systems for delivery of active agents, wherein a first fraction of an active agent is suspended in a vehicle and a second fraction of active agent is solubilized in the vehicle, with the suspended fraction representing about 5 wt. % to about 80 wt. % of the active agent and the second fraction representing about 20 wt. % to about 95 wt. % of the active agent. One or more additional active agents, which may be fully solubilized, partially solubilized, or suspended, may also be present. The first and second fractions of the active agent may or may not have different release profiles. Generally, a significant fraction of the solubilized drug will release rapidly, providing for rapid onset, while the suspended drug may be formulated for delayed and/or sustained release.

    摘要翻译： 本发明涉及用于递送活性剂的药物制剂和系统，其中活性剂的第一部分悬浮在载体中，第二部分活性剂溶解在载体中，悬浮的分数代表约5wt。 ％至约80wt。 ％的活性剂和第二级分代表约20wt。 ％至约95wt。 ％的活性剂。 还可以存在可以完全溶解，部分溶解或悬浮的一种或多种另外的活性剂。 活性剂的第一和第二部分可以具有或可以不具有不同的释放曲线。 通常，大部分的溶解药物将快速释放，提供快速发作，而悬浮药物可以配制用于延迟和/或持续释放。

    Tablet for the controlled release of active agents
    7.
    发明授权
    Tablet for the controlled release of active agents 失效
    片剂用于控释活性剂

    公开(公告)号：US6033685A

    公开(公告)日：2000-03-07

    申请号：US106658

    申请日：1998-06-29

    申请人： Yihong Qiu ,  Jay S. Trivedi ,  Sharon L. Graham ,  Kolette M. Flood ,  Steven L. Krill

    发明人： Yihong Qiu ,  Jay S. Trivedi ,  Sharon L. Graham ,  Kolette M. Flood ,  Steven L. Krill

    IPC分类号： A61K9/20 ,  A61K31/4439 ,  A61P11/08 ,  A61P11/14

    CPC分类号： A61K9/2086

    摘要： The present invention provides a tablet for the controlled release of an active agent comprising (a) a matrix layer comprising an active agent embedded in a non-swelling, non-gelling hydrophobic matrix; (b) a first barrier layer laminated to a single face of the matrix layer; and (c) an optional second barrier layer laminated to the opposite face of the matrix layer and oppositely disposed to the first barrier layer; wherein the matrix comprises up to about 80% active agent and from about 5% to about 80% by weight of nonswellable waxes or polymeric material insoluble in aqueous medium, and the first and second barrier layers independently comprise (1) polymeric material exhibiting a high degree of swelling and gelling in aqueous medium or (2) nonswellable wax or polymeric material insoluble in aqueous medium.

    摘要翻译： 本发明提供了一种用于控制释放活性剂的片剂，其包含（a）包含嵌入非溶胀非胶凝疏水基质中的活性剂的基质层; （b）层叠在基体层的单面上的第一阻挡层; 和（c）层叠到所述基质层的相对面并且相对设置于所述第一阻挡层的任选的第二阻挡层; 其中所述基质包含高达约80％的活性剂和约5％至约80％重量的不溶于水性介质的不可用的蜡或聚合物，并且所述第一和第二阻隔层独立地包含（1）表现出高的 在水介质中膨胀和凝胶化程度，或（2）不溶于水的介质中不可渗透的蜡或聚合物。