公开(公告)号：US09522081B2

公开(公告)日：2016-12-20

申请号：US13482903

申请日：2012-05-29

申请人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller ,  Matthew Smyth ,  Steven M. Rothman

发明人： Raimondo D'Ambrosio ,  Jason Fender ,  Jeffrey Ojemann ,  John W. Miller ,  Matthew Smyth ,  Steven M. Rothman

IPC分类号： A61F7/12 ,  A61F7/00 ,  A61F7/02

CPC分类号： A61F7/12 ,  A61F7/10 ,  A61F2007/0002 ,  A61F2007/0096 ,  A61F2007/0247 ,  A61F2007/108 ,  A61F2007/126

摘要： Passive prosthetic devices for focally cooling a brain and methods for inhibiting seizures are disclosed. The prosthetic devices replace a thermally insulating bone flap with a thermally conductive insert having an inner surface that contacts the relatively warm meninges or brain and an outer surface that contacts the relatively cool scalp. In an embodiment, the prosthesis is unitary; in another, a biocompatible casing is filled with a highly conductive core; in another, a filled polymer block is attached to a plate; and in another, the bone flap is filled with a conductive polymer. In one embodiment, a filled polymer containing elements that exhibit the magnetocaloric effect provide heat transfer that can be enhanced by application of a suitable magnetic field. Focal cooling as low as 1.2° C. has been found effective at inhibiting seizures.

摘要翻译： 公开了用于灶脑冷却的被动修复装置和抑制癫痫发作的方法。 假体装置用具有接触相对温暖的脑膜或脑的内表面的导热插入物和接触相对较冷的头皮的外表面替换绝热骨瓣。 在一个实施例中，假体是一体的; 在另一个中，生物相容性壳体填充有高度导电的芯; 另一方面，将填充的聚合物嵌段连接到板上; 另一方面，骨折片填充有导电聚合物。 在一个实施方案中，含有表现出磁热效应的元素的填充聚合物提供可以通过施加合适的磁场而增强的热传递。 发现低至1.2℃的局部冷却有效抑制癫痫发作。

公开(公告)号：US06978183B2

公开(公告)日：2005-12-20

申请号：US09905715

申请日：2001-05-04

申请人： Steven M. Rothman

发明人： Steven M. Rothman

IPC分类号： A61F7/00 ,  A61F7/12

CPC分类号： A61F7/12 ,  A61F2007/0076 ,  A61F2007/126

摘要： A manually activated Peltier device was placed in direct contact with a cortical slice. Seizures terminated within seconds of the onset of cooling, sometimes preceding a detectable drop in temperature measured near the top of the slice. Activation of the Peltier did not stop seizures when slices were no longer in direct physical contact with the device, indicating that this was not a field effect. When cooling was shut off and temperature returned to 33° C., the bursting sometimes returned, but a longer term suppressive effect on seizure activity could be observed. In two experiments, a custom computer program automatically detected seizure discharges and triggered a TTL pulse to activate the Peltier. In these experiments the Peltier automatically terminated the slice bursting in less than four seconds. When the Peltier device was placed in contact with the normal, exposed cortex of a newborn pig, we found that the cortical temperature rapidly decreased from 36° C. to as low as 26° C., at a depth of 1.7 mm below the cooling unit. Therefore, local cooling may rapidly terminate focal paroxysmal discharges and might be adapted for clinical practice.

摘要翻译： 将手动激活的珀耳帖装置与皮质切片直接接触。 癫痫发作在冷却开始的几秒钟内终止，有时在靠近切片顶部测量的可测量的温度下降。 当切片不再与设备直接物理接触时，珀尔帖的激活不会停止癫痫发作，表明这不是场效应。 当冷却被关闭并且温度恢复到33℃时，有时会发生爆裂，但是可以观察到对发作活动的长期抑制作用。 在两个实验中，定制的计算机程序自动检测到发作放电并触发TTL脉冲以激活珀尔帖。 在这些实验中，珀耳帖在不到4秒内自动终止切片爆裂。 当珀尔帖装置与正常暴露于新生仔猪的皮层接触时，我们发现皮质温度从36℃迅速降至低至26℃，深度低于冷却的1.7毫米 单元。 因此，局部冷却可能会迅速终止局灶性阵发性放电，并可适应临床实践。