公开(公告)号：US20090010847A9

公开(公告)日：2009-01-08

申请号：US11676830

申请日：2007-02-20

申请人： Paul Young ,  Steven Ruben

发明人： Paul Young ,  Steven Ruben

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N5/06 ,  C12P1/04 ,  G01N33/53

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47 ,  G01N33/574 ,  G01N33/6893 ,  G01N33/74 ,  G01N2800/085 ,  G01N2800/323 ,  Y02A50/401 ,  Y02A50/411 ,  Y02A50/465 ,  Y02A50/475 ,  Y02A50/58

摘要： The present invention relates to a novel human protein called Connective Tissue Growth Factor-4, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

摘要翻译： 本发明涉及称为结缔组织生长因子-4的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

公开(公告)号：US20070270504A1

公开(公告)日：2007-11-22

申请号：US10561372

申请日：2004-06-17

申请人： Paul Young ,  Qin Zong ,  Stephen Horrigan

发明人： Paul Young ,  Qin Zong ,  Stephen Horrigan

IPC分类号： C12Q1/68 ,  A61K45/00 ,  A61P35/00 ,  C07H21/02 ,  C07H21/04 ,  C12N5/10

CPC分类号： C12Q1/6886 ,  A61K45/06 ,  C12N2503/02 ,  C12Q2600/136

摘要： Methods for identifying compounds having similar biological activity based on similarity in genetic expression profile in cells contacted with one or more of said compounds, along with specifically identified compounds, are disclosed.

摘要翻译： 基于与一种或多种所述化合物接触的细胞中遗传表达谱的相似性以及特异性鉴定的化合物，鉴定具有相似生物学活性的化合物的方法。

公开(公告)号：US20070238664A1

公开(公告)日：2007-10-11

申请号：US11751886

申请日：2007-05-22

申请人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Roxanne Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

发明人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  Roxanne Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

IPC分类号： C07K14/47 ,  A61K38/00 ,  C07H21/04 ,  C12N15/63 ,  G01N33/53 ,  G01N33/48 ,  C07K16/00 ,  C07K1/00

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20070184447A1

公开(公告)日：2007-08-09

申请号：US10590256

申请日：2005-02-24

申请人： Jeffrey Strovel ,  David Bol ,  Paul Young

发明人： Jeffrey Strovel ,  David Bol ,  Paul Young

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136

摘要： Methods for the identification of disease-related gene sets and expression nprofiles, based on common chemical modulation using a specific chemical compound are disclosed.

摘要翻译： 公开了基于使用特定化合物的常规化学调节的鉴定疾病相关基因组和表达谱的方法。

公开(公告)号：US20070172830A1

公开(公告)日：2007-07-26

申请号：US10849979

申请日：2004-05-21

申请人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

发明人： Steven Ruben ,  Kimberly Florence ,  Jian Ni ,  Craig Rosen ,  Kenneth Carter ,  Paul Moore ,  Henrik Olsen ,  Yanggu Shi ,  Paul Young ,  Ying-Fei Wei ,  Laurie Brewer ,  Daniel Soppet ,  David LaFleur ,  Gregory Endress ,  Reinhard Ebner ,  Charles Birse

IPC分类号： C12Q1/68 ,  A61K48/00 ,  A61K38/17 ,  C07K14/47 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070151560A1

公开(公告)日：2007-07-05

申请号：US10559372

申请日：2004-06-14

申请人： Robert Price ,  John Stanifort ,  Derek Woodcock ,  Paul Young

发明人： Robert Price ,  John Stanifort ,  Derek Woodcock ,  Paul Young

IPC分类号： A61M15/00 ,  A61M15/08

CPC分类号： A61M15/0028 ,  A61M15/0005 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/8225 ,  A61M2209/06

摘要： The invention provides a delivery device (10) for a medicament comprising: a housing (50), a receptacle (54) holding a medicament (80) in the form of a powder; and a source of propellant (53), characterized in that the housing (50) provides an inlet (63) and an outlet (56) for the receptacle (54) wherein the inlet (63) is in fluid communication with the source of propellant (53) and is directed against the medicament (80) and the outlet (56) is spaced from the medicament (80) to allow aerosolisation of the medicament (80); the device (10) provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

摘要翻译： 本发明提供了一种用于药物的输送装置（10），包括：壳体（50），容纳有粉末形式的药物（80）的容器（54） 和推进剂源（53），其特征在于，所述壳体（50）为所述容器（54）提供入口（63）和出口（56），其中所述入口（63）与所述推进剂源流体连通 （53）并且引导所述药物（80），并且所述出口（56）与所述药物（80）间隔开，以允许所述药物（80）雾化; 装置（10）提供改善的输送效率，特别是递送的大于20重量％的细颗粒分数。

公开(公告)号：US20070056586A1

公开(公告)日：2007-03-15

申请号：US11408906

申请日：2006-04-21

申请人： Robert Price ,  John Staniforth ,  Derek Woodcock ,  Paul Young ,  James Byrnes ,  J. Cogburn ,  Douglas Dockhorn ,  Robert Dockhorn ,  Edgar Mitchell ,  Susan Prather

发明人： Robert Price ,  John Staniforth ,  Derek Woodcock ,  Paul Young ,  James Byrnes ,  J. Cogburn ,  Douglas Dockhorn ,  Robert Dockhorn ,  Edgar Mitchell ,  Susan Prather

IPC分类号： A61M15/00 ,  A61M16/00

CPC分类号： A61M15/0028 ,  A61M15/0005 ,  A61M15/0043 ,  A61M2202/064 ,  A61M2205/8225 ,  A61M2209/06

摘要： A delivery device for a medicament including: a housing, a receptacle holding a medicament in the form of a power; and a source of propellant, wherein the housing provides an inlet and an outlet for the receptacle, wherein the inlet is in fluid communication with the source of propellant and is directed against the medicament and the outlet is spaced from the medicament to allow aerosolization of the medicament; the device provides improved delivery efficiency, particularly a delivered fine particle fraction of greater than 20% by weight.

摘要翻译： 一种用于药物的输送装置，包括：壳体，容纳药物形式的容器; 以及推进剂来源，其中所述壳体提供用于所述容器的入口和出口，其中所述入口与所述推进剂源流体连通并且被引导抵靠所述药物，并且所述出口与所述药物间隔开以允许 药物; 该装置提供改进的输送效率，特别是递送的大于20重量％的细颗粒分数。

公开(公告)号：US20060280901A1

公开(公告)日：2006-12-14

申请号：US11453285

申请日：2006-06-13

申请人： James Bailey ,  Paul Young

发明人： James Bailey ,  Paul Young

IPC分类号： D04H11/00 ,  D06B3/20

CPC分类号： A47G27/0275 ,  D04H11/00 ,  Y10T428/16 ,  Y10T428/192 ,  Y10T428/23929 ,  Y10T428/23936 ,  Y10T428/2481

摘要： A carpet that can be installed onto a flooring surface without the requirement for registration between adjacent broadloom carpet pieces. The carpet comprises a design member that comprises a plurality of pattern members that are colorized and that define a void area, which has a substantially uniform color and pile height.

摘要翻译： 可以安装在地板表面上的地毯，而不需要在相邻的宽幅地毯片之间进行配准。 地毯包括设计构件，其包括多个着色的图案构件，并且限定空隙区域，其具有基本上均匀的颜色和绒头高度。

公开(公告)号：US20060099214A1

公开(公告)日：2006-05-11

申请号：US10518039

申请日：2003-06-10

申请人： Reinhard Ebner ,  Paul Young

发明人： Reinhard Ebner ,  Paul Young

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/574 ,  G06F19/00 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C07K16/30 ,  C07K14/82

CPC分类号： C12Q1/6886 ,  A61K2039/505 ,  C07K14/4748 ,  C12Q2600/136 ,  C12Q2600/16 ,  G01N33/5011 ,  G01N33/5023

摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.

公开(公告)号：US20050215775A1

公开(公告)日：2005-09-29

申请号：US10979111

申请日：2004-11-02

申请人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  D. Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

发明人： Steven Ruben ,  Craig Rosen ,  Carrie Fischer ,  Daniel Soppet ,  Kenneth Carter ,  Daniel Bednarik ,  Gregory Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul Young ,  John Greene ,  Ann Ferrie ,  D. Duan ,  Jing-Shan Hu ,  Kimberly Florence ,  Henrik Olsen ,  Reinhard Ebner ,  Laurie Brewer ,  Yanggu Shi

IPC分类号： C07H21/04 ,  C07K14/47 ,  C12N9/00 ,  C12P21/06 ,  C12Q1/68

CPC分类号： C07K14/47 ,  Y10T436/143333

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.