公开(公告)号：US07161042B2

公开(公告)日：2007-01-09

申请号：US11327876

申请日：2006-01-09

Applicant: Derek Wyndham Clissold ,  Stuart Wilbert Craig ,  Rajendrakumar Reddy Gadikota ,  Min He ,  Jurjus Fayez Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Kumar Sharma

Inventor： Derek Wyndham Clissold ,  Stuart Wilbert Craig ,  Rajendrakumar Reddy Gadikota ,  Min He ,  Jurjus Fayez Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Kumar Sharma

IPC: C07C45/00 ,  C07C41/00 ,  C07C35/06 ,  C07D311/92 ,  C07D307/87

CPC classification number: C07C45/61 ,  C07C29/03 ,  C07C29/10 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0008 ,  C07C405/0016 ,  C07C2601/08 ,  C07C49/743 ,  C07C49/235 ,  C07C49/217 ,  C07C235/30 ,  C07C35/21

Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR′ wherein n is an integer from 1 to 3 and R′ represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR″ and NHR″ wherein R″ is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

Abstract translation: 一种制备具有式（I）的前列腺素化合物的方法：其中A选自C 1 -C 6烷基; C 7 -C 16芳烷基，其中芳基部分是未取代的或被一至三个选自C 1 -C 6烷基的取代基取代， -C 6 -C 6烷基，卤素和CF 3; 和（CH 2）n N或OR'，其中n是1至3的整数，R'表示C 6 -C 6烷基， 10个未取代的或被一至三个选自C 1 -C 6烷基的取代基取代的芳基，卤素和CF _{3 ; B选自OR“和NHR”，其中R“是C 1 -C 6烷基; “img id =”CUSTOM-CHARACTER-00001“he =”2.12mm“wi =”4.57mm“file =”US07161042-20070109-P00001.TIF“alt =”custom character“img-content =”character“img- 格式=“tif”/>表示双键或单键。 还公开了新的中间体。}

公开(公告)号：US07109371B2

公开(公告)日：2006-09-19

申请号：US10751611

申请日：2004-01-05

Applicant: Derek Wyndham Clissold ,  Stuart Wilbert Craig ,  Rajendrakumar Reddy Gadikota ,  Min He ,  Jurjus Fayez Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Kumar Sharma

Inventor： Derek Wyndham Clissold ,  Stuart Wilbert Craig ,  Rajendrakumar Reddy Gadikota ,  Min He ,  Jurjus Fayez Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Kumar Sharma

IPC: C07C69/73 ,  C07C69/66 ,  C07C231/00 ,  C07C45/00 ,  C07D307/87

CPC classification number: C07C45/61 ,  C07C29/03 ,  C07C29/10 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0008 ,  C07C405/0016 ,  C07C2601/08 ,  C07C49/743 ,  C07C49/235 ,  C07C49/217 ,  C07C235/30 ,  C07C35/21

Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR′ wherein n is an integer from 1 to 3 and R′ represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR″ and NHR″ wherein R″ is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

Abstract translation: 一种制备具有式（I）的前列腺素化合物的方法：其中A选自C 1 -C 6烷基; C 7 -C 16芳烷基，其中芳基部分是未取代的或被一至三个选自C 1 -C 6烷基的取代基取代， -C 6 -C 6烷基，卤素和CF 3; 和（CH 2）n N或OR'，其中n是1至3的整数，R'表示C 6 -C 6烷基， 10个未取代的或被一至三个选自C 1 -C 6烷基的取代基取代的芳基，卤素和CF _{3 ; B选自OR“和NHR”，其中R“是C 1 -C 6烷基; 并且表示双键或单键。 还公开了新的中间体。}

公开(公告)号：US07141706B2

公开(公告)日：2006-11-28

申请号：US11327890

申请日：2006-01-09

Applicant: Derek Wyndham Clissold ,  Stuart Wilbert Craig ,  Rajendrakumar Reddy Gadikota ,  Min He ,  Jurjus Fayez Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Kumar Sharma

Inventor： Derek Wyndham Clissold ,  Stuart Wilbert Craig ,  Rajendrakumar Reddy Gadikota ,  Min He ,  Jurjus Fayez Jurayj ,  Shahrokh Kazerani ,  Erwin Rannala ,  Pradeep Kumar Sharma

IPC: C07C35/06 ,  C07D311/92 ,  C07D307/87

CPC classification number: C07C45/61 ,  C07C29/03 ,  C07C29/10 ,  C07C45/59 ,  C07C45/62 ,  C07C45/67 ,  C07C231/02 ,  C07C405/00 ,  C07C405/0008 ,  C07C405/0016 ,  C07C2601/08 ,  C07C49/743 ,  C07C49/235 ,  C07C49/217 ,  C07C235/30 ,  C07C35/21

Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR′ wherein n is an integer from 1 to 3 and R′ represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR″ and NHR″ wherein R″ is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

Abstract translation: 一种制备具有式（I）的前列腺素化合物的方法：其中A选自C 1 -C 6烷基; C 7 -C 16芳烷基，其中芳基部分是未取代的或被一至三个选自C 1 -C 6烷基的取代基取代， -C 6 -C 6烷基，卤素和CF 3; 和（CH 2）n N或OR'，其中n是1至3的整数，R'表示C 6 -C 6烷基， 10个未取代的或被一至三个选自C 1 -C 6烷基的取代基取代的芳基，卤素和CF _{3 ; B选自OR“和NHR”，其中R“是C 1 -C 6烷基; ＆lt; img id =“CUSTOM-CHARACTER-00001”he =“2.79mm”wi =“6.35mm”file =“US07141706-20061128-P00001.TIF”alt =“custom character”img-content =“character”img- 格式=“tif”/>表示双键或单键。 还公开了新的中间体。}