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公开(公告)号：US20190127305A1
公开(公告)日：2019-05-02
申请号：US16094926
申请日：2017-04-27
申请人： Givaudan SA
IPC分类号： C07C49/255 , C07C49/217 , C07C49/248 , C07C49/185 , C07D207/06 , C07D211/08
CPC分类号： C07C49/255 , A61K8/35 , A61K8/41 , A61K2800/57 , A61Q13/00 , A61Q19/10 , C07C45/562 , C07C45/61 , C07C49/185 , C07C49/213 , C07C49/217 , C07C49/245 , C07C49/248 , C07C49/76 , C07D207/06 , C07D211/08 , C07D317/46 , C11B9/0061
摘要： The present invention refers to aryl beta diketones of the formula (I) wherein Y, R1, R2 and R3 have the meaning R1 is selected from the group consisting of hydrogen, C1-C4 alkyl, hydroxyl, methoxy, CF3 and F; R2 is selected from the group consisting of methyl and ethyl; R3 is selected from the group consisting of methyl and ethyl; and Y is a bivalent residue selected from the group consisting of —C(O)—; —CH2═CH2—C(O)—; —CRIRII—C(O)—, wherein RI and RII are independently selected from hydrogen and methyl; and —CHRIII—CHRIV—C(O)—, wherein RIII and RIV are independently selected from hydrogen and methyl with the proviso, that RIII═RIV are hydrogen or either RIII or RIV is methyl. The invention further refers to fragrance compositions and fragranced articles comprising them.
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公开(公告)号：US20180105477A1
公开(公告)日：2018-04-19
申请号：US15565133
申请日：2016-11-29
发明人： YOUGUI ZHOU , MING YU , JINTAO YUAN , LEI ZHAO , XIANDONG ZHU , GUANGXIONG YU , WEIWEI SU , WEIKANG SHAO , XINGXING SHI , YIN ZHANG , MING FENG , ZHIRONG CHEN , HAORAN LI , YUHONG ZHANG
IPC分类号： C07B53/00 , B01J31/02 , B01J23/46 , C07C45/62 , C07C47/21 , C07C47/225 , C07C47/232 , C07C49/21 , C07C49/217 , C07D307/46 , C07D333/22
CPC分类号： C07B53/00 , B01J23/462 , B01J23/464 , B01J23/468 , B01J31/02 , B01J31/0237 , C07C45/62 , C07C47/21 , C07C47/225 , C07C47/232 , C07C49/21 , C07C49/217 , C07C67/303 , C07C201/12 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07D307/46 , C07D333/22 , Y02P20/584 , C07C205/44 , C07C47/02 , C07C47/19 , C07C47/198 , C07C47/23 , C07C69/716 , C07C47/24 , C07C49/403 , C07C47/277 , C07C49/175 , C07C49/213 , C07C49/215 , C07C49/427
摘要： The present invention discloses a method for preparing optically active carbonyl compound, comprising the following steps: under the catalysis of chiral amine salt and transition metal catalysts, with hydrogen and catalytic amount of dihydropyridine compound as hydrogen source, use α, β-unsaturated aldehydes or α, β-unsaturated troponoid compounds to conduct asymmetric catalytic reaction to obtain the optically active carbonyl compound. This method comes in moderate reaction condition, simple operation, and catalytic amount of dihydropyridine compounds usage, the target product is easy to be separated and purified from the reaction system, and the metal catalyst can be recycled, it is economical.
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公开(公告)号：US20120201778A1
公开(公告)日：2012-08-09
申请号：US13379278
申请日：2010-06-17
申请人： André Casazza , Raymond Kerverdo , Lydia Ziegler , Hugues Brevard
发明人： André Casazza , Raymond Kerverdo , Lydia Ziegler , Hugues Brevard
IPC分类号： A61L9/01 , C07C49/21 , C07C49/207
CPC分类号： A61L9/01 , A61K8/35 , A61L2/18 , A61L2/22 , A61L2/232 , A61L9/14 , A61L2202/25 , A61L2209/21 , A61Q15/00 , C07C49/207 , C07C49/217 , C07D307/46
摘要： The invention relates to novel deodorant compositions containing at least one compound of the family of acetylenic ketones and the deodorant products containing them. A particularly preferred composition according to the invention comprises at least one compound of the family of the α-acetylenic ketones and a mixture of aldehydes chosen from two different families.
摘要翻译： 本发明涉及含有至少一种炔属酮族化合物和含有它们的除臭剂的新型除臭剂组合物。 根据本发明的特别优选的组合物包含至少一种α-炔酮的家族化合物和选自两个不同家族的醛的混合物。
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公开(公告)号：US07491684B2
公开(公告)日：2009-02-17
申请号：US11055146
申请日：2005-02-10
IPC分类号： A61Q13/00
CPC分类号： A61Q13/00 , A61K8/34 , A61K8/35 , C07C33/03 , C07C33/12 , C07C33/14 , C07C45/29 , C07C49/203 , C07C49/217 , C07C49/647 , C07C49/794 , C07C403/08 , C07C2601/08 , C07C2601/14
摘要： The present invention is directed to novel ketone and alcohol compounds and the use of these novel compounds in creating fragrances, and scents in items such as perfumes, colognes and personal care products.
摘要翻译： 本发明涉及新颖的酮和醇化合物以及这些新颖化合物在制造香料中的用途，以及香料，古龙水和个人护理产品中的香料。
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5.发明申请Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states 失效查耳酮及其类似物作为抑制血管生成和相关疾病状态的药剂公开(公告)号：US20090018167A1
公开(公告)日：2009-01-15
申请号：US12229340
申请日：2008-08-22
IPC分类号： A61K31/444 , C07C49/76 , C07D311/04 , C07D307/30 , C07D213/44 , A61K31/44 , A61P25/02 , A61P19/02 , A61P17/10 , C07D211/82 , A61K31/12 , A61K31/352 , A61K31/341
CPC分类号： C07D207/333 , C07C49/217 , C07C49/223 , C07C49/233 , C07C49/235 , C07C49/683 , C07C49/697 , C07C49/782 , C07C49/796 , C07C49/813 , C07C49/84 , C07D213/50 , C07D307/46
摘要： The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, including angiogenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.
摘要翻译： 本发明涉及可用作血管发生抑制剂的查耳酮和查耳酮衍生物和类似物。 合成成本低的本发明化合物作为血管生成抑制剂表现出意想不到的良好活性。 本发明还涉及查耳酮及其类似物作为抗肿瘤/抗癌剂并用于治疗血管生成是其中一个因素的一些病症或疾病状态，包括血管生成皮肤疾病如牛皮癣，痤疮，酒渣鼻，疣，湿疹 ，血管瘤，淋巴管生成等等，以及慢性炎性疾病如关节炎。
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公开(公告)号：US07235698B2
公开(公告)日：2007-06-26
申请号：US11215449
申请日：2005-08-29
CPC分类号： C07C45/67 , C07B2200/07 , C07C45/511 , C07C45/54 , C07C45/673 , C07C45/676 , C07C67/343 , C07C2601/14 , C07C2601/18 , C07C49/647 , C07C49/794 , C07C49/217 , C07C49/755 , C07C49/653 , C07C49/753 , C07C49/697 , C07C49/687 , C07C49/683 , C07C69/738
摘要： Compounds containing a substituted or unsubstituted allyl group directly bound to a chiral carbon atom are prepared enantioselectively. Starting reactants are either chiral or achiral, and may or may not contain an attached allyloxycarbonyl group as a substituent. Chiral ligands are employed, along with transition metal catalysts. The methods of the invention are effective in providing enantioconvergent allylation of chiral molecules.
摘要翻译： 对映选择性地制备含有与手性碳原子直接结合的取代或未取代的烯丙基的化合物。 起始反应物是手性或非手性的，并且可以含有或可以不含有连接的烯丙氧基羰基作为取代基。 使用手性配体以及过渡金属催化剂。 本发明的方法在提供手性分子的对映异构烯丙基化方面是有效的。
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公开(公告)号：US20060106235A1
公开(公告)日：2006-05-18
申请号：US11327876
申请日：2006-01-09
申请人： Derek Clissold , Stuart Craig , Rajendrakumar Gadikota , Min He , Jurjus Jurayj , Shahrokh Kazerani , Erwin Rannala , Pradeep Sharma
发明人： Derek Clissold , Stuart Craig , Rajendrakumar Gadikota , Min He , Jurjus Jurayj , Shahrokh Kazerani , Erwin Rannala , Pradeep Sharma
IPC分类号： C07F7/10 , C07D315/00
CPC分类号： C07C45/61 , C07C29/03 , C07C29/10 , C07C45/59 , C07C45/62 , C07C45/67 , C07C231/02 , C07C405/00 , C07C405/0008 , C07C405/0016 , C07C2601/08 , C07C49/743 , C07C49/235 , C07C49/217 , C07C235/30 , C07C35/21
摘要： A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1-C6 alkyl groups; C7-C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; and (CH2)nOR′ wherein n is an integer from 1 to 3 and R′ represents a C6-C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1-C6 alkyl groups, halo and CF3; B is selected from OR″ and NHR″ wherein R″ is C1-C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.
摘要翻译： 一种制备具有式（I）的前列腺素化合物的方法：其中A选自C 1 -C 6烷基; C 7 -C 16芳烷基，其中芳基部分是未取代的或被一至三个选自C 1 -C 6烷基的取代基取代， -C 6 -C 6烷基，卤素和CF 3; 和（CH 2）n N或OR'，其中n是1至3的整数，R'表示C 6 -C 6烷基， 10个未取代的或被一至三个选自C 1 -C 6烷基的取代基取代的芳基，卤素和CF 3 ; B选自OR“和NHR”，其中R“是C 1 -C 6烷基; “img id =”custom-character-00001“he =”2.12mm“wi =”4.57mm“file =”US20060106235A1-20060518-P00900.TIF“alt =”custom character“img-content =”character“img- 格式=“tif”/>表示双键或单键。 还公开了新的中间体。
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公开(公告)号：US20060084820A1
公开(公告)日：2006-04-20
申请号：US11215449
申请日：2005-08-29
申请人： Douglas Behenna , Brian Stoltz , Justin Mohr , Andrew Harned
发明人： Douglas Behenna , Brian Stoltz , Justin Mohr , Andrew Harned
CPC分类号： C07C45/67 , C07B2200/07 , C07C45/511 , C07C45/54 , C07C45/673 , C07C45/676 , C07C67/343 , C07C2601/14 , C07C2601/18 , C07C49/647 , C07C49/794 , C07C49/217 , C07C49/755 , C07C49/653 , C07C49/753 , C07C49/697 , C07C49/687 , C07C49/683 , C07C69/738
摘要： Compounds containing a substituted or unsubstituted allyl group directly bound to a chiral carbon atom are prepared enantioselectively. Starting reactants are either chiral or achiral, and may or may not contain an attached allyloxycarbonyl group as a substituent. Chiral ligands are employed, along with transition metal catalysts. The methods of the invention are effective in providing enantioconvergent allylation of chiral molecules.
摘要翻译： 对映选择性地制备含有与手性碳原子直接结合的取代或未取代的烯丙基的化合物。 起始反应物是手性或非手性的，并且可以含有或可以不含有连接的烯丙氧基羰基作为取代基。 使用手性配体以及过渡金属催化剂。 本发明的方法在提供手性分子的对映异构烯丙基化方面是有效的。
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9.发明申请Production method of (R)-3- hydroxy-3-(2-phenylethyl)hexanoic acid and intermediate thereof 失效（R）-3-羟基-3-（2-苯基乙基）己酸及其中间体的制备方法公开(公告)号：US20040138496A1
公开(公告)日：2004-07-15
申请号：US10727398
申请日：2003-12-04
发明人： Masahide Tanaka , Kozo Matsui , Tadashi Katsura , Mitsuhiro Iwasaki , Hiroshi Maeda , Nobushige Itaya
IPC分类号： C07C051/347
CPC分类号： C07C45/74 , C07B2200/07 , C07C45/62 , C07C45/73 , C07C49/213 , C07C51/43 , C07C51/487 , C07C69/732 , C07C211/29 , C07C217/58 , C07C49/217 , C07C59/48
摘要： The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) 1 wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.
摘要翻译： 本发明涉及（R）-3-羟基-3-（2-苯基乙基）己酸的制备方法，该方法包括用光学活性胺将外消旋3-羟基-3-（2-苯基乙基）己酸旋光拆分 的式（VIII）其中R 2是3,4-二甲氧基苯基或2-氯苯基。 根据本发明，可以以高光学纯度和较高的总产率有效地制备可用作药剂原料的（R）-3-羟基-3-（2-苯基乙基）己酸。
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10.发明申请Production method of (R) -3 hydroxy-3- (2-phenylethyl) hexanoic acid and intermediate thereof 失效（R）-3-羟基-3-（2-苯基乙基）己酸及其中间体的制备方法公开(公告)号：US20030176507A1
公开(公告)日：2003-09-18
申请号：US10320325
申请日：2002-12-16
发明人： Masahide Tanaka , Kozo Matsui , Tadashi Katsura , Mitsuhiro Iwasaki , Hiroshi Maeda , Nobushige Itaya
IPC分类号： A61K031/192 , C07C059/64
CPC分类号： C07C45/74 , C07B2200/07 , C07C45/62 , C07C45/73 , C07C49/213 , C07C51/43 , C07C51/487 , C07C69/732 , C07C211/29 , C07C217/58 , C07C49/217 , C07C59/48
摘要： The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) 1 wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.
摘要翻译： 本发明涉及（R）-3-羟基-3-（2-苯基乙基）己酸的制备方法，该方法包括用光学活性胺将外消旋3-羟基-3-（2-苯基乙基）己酸旋光拆分 其中R 2是3,4-二甲氧基苯基或2-氯苯基。 根据本发明，可以以高光学纯度和较高的总产率有效地制备可用作药剂原料的（R）-3-羟基-3-（2-苯基乙基）己酸。
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