公开(公告)号：US08623368B2

公开(公告)日：2014-01-07

申请号：US13503103

申请日：2010-10-22

申请人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Hyun Bo Shim ,  Kyung Jae Kang

发明人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Hyun Bo Shim ,  Kyung Jae Kang

IPC分类号： A61K39/395 ,  C07K16/28 ,  G01N33/53

CPC分类号： C07K14/70542 ,  A61K2039/505 ,  C07K16/2836 ,  C07K2317/24 ,  C07K2319/30 ,  G01N33/57484 ,  G01N33/577 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/525 ,  G01N2333/70542 ,  G01N2800/24 ,  G01N2800/32 ,  Y02A50/412 ,  Y02A50/58

摘要： The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.

摘要翻译： 本发明涉及特异性结合人血管细胞粘附分子-1（VCAM-1）以抑制白细胞与激活的内皮细胞之间的粘附和通过活化的内皮细胞的白细胞迁移的人重组单克隆抗体，以及预防和治疗 包含其的炎性疾病或癌症的组合物。 根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1的强亲和力，并且有效抑制白细胞和激活的内皮细胞之间的VCAM-1介导的粘附和白细胞通过活化的内皮细胞的迁移，从而 用于预防和治疗炎性疾病如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。

公开(公告)号：US20120276091A1

公开(公告)日：2012-11-01

申请号：US13503103

申请日：2010-10-22

申请人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Hyun Bo Shim ,  Kyung Jae Kang

发明人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Hyun Bo Shim ,  Kyung Jae Kang

IPC分类号： C07K16/28 ,  C12N5/07 ,  A61P35/00 ,  A61P29/00 ,  A61P9/00 ,  G01N33/53 ,  A61K39/395

CPC分类号： C07K14/70542 ,  A61K2039/505 ,  C07K16/2836 ,  C07K2317/24 ,  C07K2319/30 ,  G01N33/57484 ,  G01N33/577 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/525 ,  G01N2333/70542 ,  G01N2800/24 ,  G01N2800/32 ,  Y02A50/412 ,  Y02A50/58

摘要： The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.

摘要翻译： 本发明涉及特异性结合人血管细胞粘附分子-1（VCAM-1）以抑制白细胞与激活的内皮细胞之间的粘附和通过活化的内皮细胞的白细胞迁移的人重组单克隆抗体，以及预防和治疗 包含其的炎性疾病或癌症的组合物。 根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1的强亲和力，并且有效抑制白细胞和激活的内皮细胞之间的VCAM-1介导的粘附和白细胞通过活化的内皮细胞的迁移，从而 用于预防和治疗炎性疾病如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。

公开(公告)号：US08715670B2

公开(公告)日：2014-05-06

申请号：US13262212

申请日：2010-03-31

申请人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Il Sun Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Young Woo Park ,  So Young Choi ,  Ji Hyun Park ,  Myeoung Hee Jang

发明人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Il Sun Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Young Woo Park ,  So Young Choi ,  Ji Hyun Park ,  Myeoung Hee Jang

IPC分类号： A61K39/395 ,  C07K16/28 ,  G01N33/53

CPC分类号： C07K16/2836 ,  A61K2039/505 ,  C07K14/70542 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

摘要： The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.

摘要翻译： 本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。 根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗 的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。

公开(公告)号：US20120308574A1

公开(公告)日：2012-12-06

申请号：US13262212

申请日：2010-03-31

申请人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Il Sun Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Young Woo Park ,  So Young Choi ,  Ji Hyun Park ,  Myeoung Hee Jang

发明人： Jung Tae Lee ,  Kyung Duk Moon ,  Ji Yong Yoon ,  Byung Je Sung ,  Dong Heon Lee ,  Il Sun Lee ,  Dong Eun Lee ,  Su Yeon Ryu ,  Young Woo Park ,  So Young Choi ,  Ji Hyun Park ,  Myeoung Hee Jang

IPC分类号： A61K39/395 ,  G01N33/574 ,  C07K16/18 ,  A61P9/10 ,  A61P35/00 ,  A61P11/06 ,  A61P1/00 ,  G01N33/566 ,  A61P29/00

CPC分类号： C07K16/2836 ,  A61K2039/505 ,  C07K14/70542 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30

摘要： The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.

摘要翻译： 本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。 根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗 的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。