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1.发明授权Human recombinant monoclonal antibody that specifically binds to VCAM-1 and inhibits adhesion and transmigration between leukocytes and endothelial cells 失效与VCAM-1特异性结合并抑制白细胞和内皮细胞之间粘附和迁移的人重组单克隆抗体公开(公告)号：US08623368B2
公开(公告)日：2014-01-07
申请号：US13503103
申请日：2010-10-22
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53
CPC分类号： C07K14/70542 , A61K2039/505 , C07K16/2836 , C07K2317/24 , C07K2319/30 , G01N33/57484 , G01N33/577 , G01N33/6893 , G01N33/74 , G01N2333/525 , G01N2333/70542 , G01N2800/24 , G01N2800/32 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.
摘要翻译： 本发明涉及特异性结合人血管细胞粘附分子-1（VCAM-1）以抑制白细胞与激活的内皮细胞之间的粘附和通过活化的内皮细胞的白细胞迁移的人重组单克隆抗体，以及预防和治疗 包含其的炎性疾病或癌症的组合物。 根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1的强亲和力，并且有效抑制白细胞和激活的内皮细胞之间的VCAM-1介导的粘附和白细胞通过活化的内皮细胞的迁移，从而 用于预防和治疗炎性疾病如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。
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2.发明申请Human Recombinant Monoclonal Antibody That Specifically Binds to VCAM-1 and Inhibits Adhesion and Transmigration Between Leukocytes and Endothelial Cells 失效与VCAM-1特异性结合并抑制白细胞与内皮细胞之间粘附和转移的人重组单克隆抗体公开(公告)号：US20120276091A1
公开(公告)日：2012-11-01
申请号：US13503103
申请日：2010-10-22
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
CPC分类号： C07K14/70542 , A61K2039/505 , C07K16/2836 , C07K2317/24 , C07K2319/30 , G01N33/57484 , G01N33/577 , G01N33/6893 , G01N33/74 , G01N2333/525 , G01N2333/70542 , G01N2800/24 , G01N2800/32 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.
摘要翻译： 本发明涉及特异性结合人血管细胞粘附分子-1（VCAM-1）以抑制白细胞与激活的内皮细胞之间的粘附和通过活化的内皮细胞的白细胞迁移的人重组单克隆抗体，以及预防和治疗 包含其的炎性疾病或癌症的组合物。 根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1的强亲和力，并且有效抑制白细胞和激活的内皮细胞之间的VCAM-1介导的粘附和白细胞通过活化的内皮细胞的迁移，从而 用于预防和治疗炎性疾病如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。
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公开(公告)号：US09279014B2
公开(公告)日：2016-03-08
申请号：US14239216
申请日：2012-08-17
申请人： Hye Soon Won , Byung Je Sung , Yong Ho Ahn , Sang Kyung Park
发明人： Hye Soon Won , Byung Je Sung , Yong Ho Ahn , Sang Kyung Park
IPC分类号： C07K14/705 , C07K14/715
CPC分类号： C07K14/70578 , C07K14/7151 , C07K2319/30
摘要： The present invention relates to a method for separating and preparing a TNFR-Fc fusion protein using hydrophobic interaction chromatography (HIC). More particularly, the present invention relates to a method for separating and preparing a highly pure active protein from clipped proteins due to displacement effect by adjusting the conductivity of a protein sample using a high concentration of salt solution and by adjusting a loading amount thereof, and a TNFR-Fc fusion protein prepared by the method.
摘要翻译： 本发明涉及使用疏水相互作用色谱（HIC）分离和制备TNFR-Fc融合蛋白的方法。 更具体地说，本发明涉及通过调节使用高浓度的盐溶液的蛋白质样品的电导率并调整其负载量，由于置换效应而从夹带蛋白质中分离和制备高纯度活性蛋白的方法，以及 通过该方法制备的TNFR-Fc融合蛋白。
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公开(公告)号：US20140316114A1
公开(公告)日：2014-10-23
申请号：US14239216
申请日：2012-08-17
申请人： Hye Soon Won , Byung Je Sung , Yong Ho Ahn , Sang Kyung Park
发明人： Hye Soon Won , Byung Je Sung , Yong Ho Ahn , Sang Kyung Park
IPC分类号： C07K14/705
CPC分类号： C07K14/70578 , C07K14/7151 , C07K2319/30
摘要： The present invention relates to a method for separating and preparing a TNFR-Fc fusion protein using hydrophobic interaction chromatography (HIC). More particularly, the present invention relates to a method for separating and preparing a highly pure active protein from clipped proteins due to displacement effect by adjusting the conductivity of a protein sample using a high concentration of salt solution and by adjusting a loading amount thereof, and a TNFR-Fc fusion protein prepared by the method.
摘要翻译： 本发明涉及使用疏水相互作用色谱（HIC）分离和制备TNFR-Fc融合蛋白的方法。 更具体地说，本发明涉及通过调节使用高浓度的盐溶液的蛋白质样品的电导率并调整其负载量，由于置换效应而从夹带蛋白质中分离和制备高纯度活性蛋白的方法，以及 通过该方法制备的TNFR-Fc融合蛋白。
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5.发明申请HUMAN MONOCLONAL ANTIBODY THAT SPECIFICALLY BINDS TO VCAM-1 AND A COMPOSITION FOR TREATING AN INFLAMMATORY DISEASE OR A CANCER COMPRISING THE SAME 失效对VCAM-1特异性结合的人类单克隆抗体和用于治疗炎症性疾病的组合物或包含其的癌症公开(公告)号：US20120308574A1
公开(公告)日：2012-12-06
申请号：US13262212
申请日：2010-03-31
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
IPC分类号： A61K39/395 , G01N33/574 , C07K16/18 , A61P9/10 , A61P35/00 , A61P11/06 , A61P1/00 , G01N33/566 , A61P29/00
CPC分类号： C07K16/2836 , A61K2039/505 , C07K14/70542 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.
摘要翻译： 本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。 根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗 的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。
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6.发明授权Human monoclonal antibody that specifically binds to VCAM-1 and a composition for treating an inflammatory disease or a cancer comprising the same 失效特异性结合VCAM-1的人单克隆抗体和用于治疗炎性疾病的组合物或包含其的癌症公开(公告)号：US08715670B2
公开(公告)日：2014-05-06
申请号：US13262212
申请日：2010-03-31
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2836 , A61K2039/505 , C07K14/70542 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.
摘要翻译： 本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。 根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗 的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。
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