公开(公告)号：US20150030600A1

公开(公告)日：2015-01-29

申请号：US13813623

申请日：2011-08-31

Applicant: James D. Marks ,  Yongfeng Fan ,  Jianlong Lou ,  Maria Consuelo Garcia Rodriguez ,  Shude Yan ,  Isin Nergiz Geren ,  Wenwu Zhai ,  Subhendu Chakraborti

Inventor： James D. Marks ,  Yongfeng Fan ,  Jianlong Lou ,  Maria Consuelo Garcia Rodriguez ,  Shude Yan ,  Isin Nergiz Geren ,  Wenwu Zhai ,  Subhendu Chakraborti

IPC: C07K16/12 ,  G01N33/569 ,  G01N33/573

CPC classification number: C07K16/40 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/1282 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56911 ,  G01N33/573 ,  G01N2333/33 ,  G01N2333/952

Abstract: The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.

Abstract translation: 本公开提供了特异性结合肉毒杆菌神经毒素（例如BoNT / A，BoNT / B，BoNT / C，BoNT / D，BoNT / E，BoNT / F，BoNT / G等）的抗体， 那些抗体。 特异性结合本文提供的中和表位的抗体及其衍生物可用于中和肉毒杆菌神经毒素，因此也可用于治疗肉毒中毒。