公开(公告)号：US4126495A

公开(公告)日：1978-11-21

申请号：US786730

申请日：1977-04-11

申请人： Subrata Ghosh

发明人： Subrata Ghosh

IPC分类号： C22C19/05

CPC分类号： C22C19/056

摘要： New nickel-base superalloys with good overall properties, the alloys being particularly adapted for high temperature applications at about 1800.degree. F. to 2000.degree. F., such as for turbine engine or other high temperature, high stress applications, and possessing a complex, multi-component gamma prime Ni.sub.3 Al.sub.1 matrix (not necessarily in the exact 3:1 proportion) in which both the nickel and aluminum atoms are partially replaced by, and/or containing, one or more of the following elements: Cr, Ti, Co, Mo and Ta. The nickel and aluminum may also be partially replaced by one or more of the following elements: W, C, Cb, Be, B, Zr and rare earths, such as for example, mischmetal. The gamma prime Ni.sub.3 Al.sub.1 matrix phase precipitates a delta Ni.sub.1 Al.sub.1 phase (not necessarily in the exact 1:1 proportion) at elevated temperatures (termed herein "inverse precipitation") thus providing critical high temperature strengthening of the matrix. Additionally, the alloy structure may contain a quantity of carbides, some borides and some nitrides.

公开(公告)号：US4082581A

公开(公告)日：1978-04-04

申请号：US386894

申请日：1973-08-09

申请人： Subrata Ghosh

发明人： Subrata Ghosh

IPC分类号： C22C19/05

CPC分类号： C22C19/056

摘要： New nickel-base superalloys with good overall properties, the alloys being particularly adapted for high temperature applications at about 1800.degree. F. to 2000.degree. F., such as for turbine engine or other high temperature, high stress applications, and possessing a complex, multi-component gamma prime Ni.sub.3 Al.sub.1 matrix (not necessarily in the exact 3:1 proportion) in which both the nickel and aluminum atoms are partially replaced by, and/or containing, one or more of the following alloying elements: Cr, Ti, Co, Mo, Ta, W, C, Cb, Be, B, Zr and rare earths, such as for example, mischmetal. The gamma prime Ni.sub.3 Al.sub.1 matrix phase precipitates a delta Ni.sub.1 Al.sub.1 phase (not necessarily in the exact 1:1 proportion) at elevated temperatures (termed herein "inverse precipitation") thus providing critical high temperature strengthening of the matrix. Additionally, the alloy structure contains a fairly large quantity of carbides, some borides and some nitrides.

摘要翻译： 新的镍基超级合金具有良好的总体性能，该合金特别适用于约1800°F至2000°F的高温应用，例如用于涡轮发动机或其他高温，高应力应用，并且具有复杂的， 其中镍和铝原子都被一种或多种以下元素部分置换和/或含有：Cr，Ti，Co， 莫和塔。 镍和铝也可以被一种或多种以下元素部分地替代：W，C，Cb，Be，B，Zr和稀土，例如混合稀土。 伽马级Ni3Al1基体相在升高的温度（本文称为“反相沉淀”）下沉淀出ΔIiAlAl相（不一定以精确的1:1比例），从而提供基体的关键的高温强化。 此外，合金结构可能含有一定量的碳化物，一些硼化物和一些氮化物。

公开(公告)号：US20130158112A1

公开(公告)日：2013-06-20

申请号：US13527844

申请日：2012-06-20

申请人： Jonathan D. Smith ,  Enakshi Chakrabarti ,  Subrata Ghosh ,  Marti Sayre ,  Gregory Tochtrop

发明人： Jonathan D. Smith ,  Enakshi Chakrabarti ,  Subrata Ghosh ,  Marti Sayre ,  Gregory Tochtrop

IPC分类号： C07C323/56 ,  C07C233/69 ,  C07C323/45 ,  C07C323/42 ,  C07C317/28

CPC分类号： C07C323/56 ,  C07C233/69 ,  C07C317/28 ,  C07C323/42 ,  C07C323/45 ,  C07C323/60 ,  C07C2601/02

摘要： A pharmaceutical composition for inhibiting amyloid beta peptide in a subject includes a compound having the formula (I): where M is selected from a substituted or unsubstituted alkyl, halo, alkoxy, aryl, cyclic, or heterocyclic group; p is an integer from 0-3; X1 is a 3-9 atoms in length linker connecting A and B; B is selected from a substituted or unsubstituted aryl, alkoxy or amine group; and a pharmaceutically acceptable salt thereof; and a pharmaceutical carrier.

摘要翻译： 用于抑制受试者中淀粉样β肽的药物组合物包括具有式（I）的化合物：其中M选自取代或未取代的烷基，卤素，烷氧基，芳基，环状或杂环基; p是0-3的整数; X1是连接A和B的长度为3-9个原子的连接体; B选自取代或未取代的芳基，烷氧基或胺基; 及其药学上可接受的盐; 和药用载体。

公开(公告)号：US20130129579A1

公开(公告)日：2013-05-23

申请号：US13806197

申请日：2011-06-23

申请人： Anna Moore ,  Zdravka Medarova ,  Subrata Ghosh

发明人： Anna Moore ,  Zdravka Medarova ,  Subrata Ghosh

IPC分类号： G01N21/78

CPC分类号： G01N21/78 ,  G01N21/03 ,  G01N21/0303 ,  G01N21/253 ,  G01N21/8483 ,  G01N33/493 ,  G01N33/52 ,  G01N2021/0325

摘要： A method and device for detecting an analyte in a solution or compound mixture use colorimetric detection to detect the quantity of an analyte in the solution or compound. The analyte sensor demonstrates a clear change in peak light absorption wavelength as a function of the stoichiometric relationship between the analyte sensor and the analyte. The method involves combining the analyte sensor and the analyte in solution and observing a color change of the mixture. Additionally, predefined amounts of the analyte sensor can be added until color change is detected and the quantity of analyte can be determined as a function of the total amount of analyte sensor in the mixture. Alternatively, a device having multiple wells or compartments, each with a different concentration of the analyte sensor. The analyte sample can be introduced to each well and the well that demonstrates the color change can, from its know analyte sensor concentration, be used to quickly and accurately determine the concentration of the analyte.

摘要翻译： 用于检测溶液或化合物混合物中的分析物的方法和装置使用比色检测来检测溶液或化合物中分析物的量。 分析物传感器表现出峰值光吸收波长的明显变化，作为分析物传感器和分析物之间的化学计量关系的函数。 该方法包括将分析物传感器和分析物结合在溶液中并观察混合物的颜色变化。 另外，可以添加预定量的分析物传感器，直到检测到颜色变化，并且可以将分析物的量确定为混合物中分析物传感器的总量的函数。 或者，具有多个孔或隔室的装置，每个具有不同浓度的分析物传感器。 可以将分析物样品引入每个孔，并且证明颜色变化的孔可以从其已知的分析物传感器浓度用于快速且准确地确定分析物的浓度。