公开(公告)号：US20130171280A1

公开(公告)日：2013-07-04

申请号：US13290357

申请日：2011-11-07

Applicant: Suengmok Cho ,  Daeseok Han ,  Dong-Soo Kim ,  Nam-In Baek ,  Young-Ho Jin ,  Jin-Kyu Han ,  Jae-Young Sung ,  In-Ho Kim ,  Chang-Ho Lee

Inventor： Suengmok Cho ,  Daeseok Han ,  Dong-Soo Kim ,  Nam-In Baek ,  Young-Ho Jin ,  Jin-Kyu Han ,  Jae-Young Sung ,  In-Ho Kim ,  Chang-Ho Lee

IPC: A61K36/899

CPC classification number: A61K36/899 ,  A61K2236/13

Abstract: Disclosed is a novel use of rice, rice bran or rice hull extract as a histamine receptor antagonist. The rice, rice bran or rice hull extract may be used as a natural antihistamine to prevent or treat allergic rhinitis, inflammatory bowel disease, asthma, bronchitis, nausea, gastric and duodenal ulcer, gastroesophageal reflux disease, sleep disorder, anxiety and depression. It provides comparable or better effect of decreasing sleep latency, increasing sleep duration and increasing non-REM sleep as compared to diazepam, which is currently used as sleeping drug. Derived from the natural product rice, rice bran or rice hull, it has no side effect such as cognitive impairment, resistance or dependency even after long-term use.

Abstract translation: 披露了米，米糠或稻壳提取物作为组胺受体拮抗剂的新用途。 大米，米糠或米壳提取物可用作天然抗组胺药，以预防或治疗过敏性鼻炎，炎性肠病，哮喘，支气管炎，恶心，胃和十二指肠溃疡，胃食管反流病，睡眠障碍，焦虑和抑郁。 与目前用作睡眠药物的地西泮相比，它提供了降低睡眠潜伏期，增加睡眠持续时间和增加非REM睡眠的可比较或更好的效果。 从天然产物米，米糠或稻壳衍生而来，即使长期使用，也不会有认知障碍，抵抗力或依赖性等副作用。